Patents Assigned to MIT
  • Patent number: 6139773
    Abstract: The invention relates to cyclohexane derivatives of the formula I in which n, m, p, R.sup.1, X.sup.1, X.sup.2, X.sup.3, Z.sup.1, Z.sup.2, Z.sup.3, A.sup.1, A.sup.2 and Y are as defined herein.
    Type: Grant
    Filed: June 4, 1998
    Date of Patent: October 31, 2000
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Peer Kirsch, Kazuaki Tarumi, Joachim Krause
  • Patent number: 6140507
    Abstract: The present invention relates to a novel process for the selective debenzylation of dibenzylbiotin, which is formed as an intermediate in the synthesis of biotin, but is usually not isolated.
    Type: Grant
    Filed: December 13, 1999
    Date of Patent: October 31, 2000
    Assignee: Merck Patent Gesellschaft mit
    Inventors: Ulrich Heywang, Heinrich Bollinger, Hans-Rudolf Muller
  • Patent number: 6139962
    Abstract: The present invention relates to surface-modified pigments based on platelet-shaped substrates, having improved settling and reagitation characteristics, and to their preparation processes and use.
    Type: Grant
    Filed: September 28, 1998
    Date of Patent: October 31, 2000
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Gerhard Herget, Brigitte Husseini
  • Patent number: 6136445
    Abstract: The invention is directed to a lacquer coating for polymer sheet and a method for applying the coated polymer sheet to a molded body. The lacquer contains a binder, a metal pigment, a color pigment, organic solvent in water wherein the binder includes a combination of hard and flexible resins. The ratio of these resin is adjusted so that the elastic-plastic behavior of the lacquer coating matches that of the plastic polymer sheet. In this fashion, the coated sheet can be deformed without causing substantial blistering or cracking of the coating on the polymer sheet.
    Type: Grant
    Filed: July 16, 1996
    Date of Patent: October 24, 2000
    Assignee: Herberts Gesellschaft mit Beschrankter Haftung
    Inventors: Christian Gruner, Reinhart Schmitt, Hans-Peter Patzschke
  • Patent number: 6136925
    Abstract: The invention relates to separating materials based on supports containing hydroxyl groups, whose surface [sic] are coated with covalently bound polymers, and to processes for their preparation. The separating materials are characterized in that the polymers consist of identical recurring units of the formula I.brket open-st.CH.sub.2 --CHX.brket close-st..sub.n (I)in whichX is CO--NH--CH.sub.2 --CH.sub.2 --SO.sub.3 H andn is 2-100.
    Type: Grant
    Filed: July 22, 1997
    Date of Patent: October 24, 2000
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Egbert Muller, Margot Mack, Lothar Britsch
  • Patent number: 6137576
    Abstract: Optical transducers for measuring a contaminant in a gas are disclosed, whereby said contaminant interacts with a liquid crystalline phase as a sensing element in a flow cell. According to the invention nematic crystalline phases on a orientation layer are used. Means are provided to measure or to detect changes of the refractive index of said liquid crystalline phase caused by interaction of said contaminant with said liquid crystalline phase. In preferred embodiments the means for measuring or for detecting the refractive index is a Mach-Zehnder interferometer, a grating coupler, or a device for e.g. visual detection, whereby the flow cell is placed between two linearly polarizing filters, and whereby the two axis of polarization are crossed. Furthermore optical transducers are disclosed, which contain an isotropic dopant in a liquid crystalline phase.
    Type: Grant
    Filed: July 28, 1998
    Date of Patent: October 24, 2000
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Detlef Pauluth, Joachim Krause, Gunter Gauglitz, Bernd Drapp
  • Patent number: 6132873
    Abstract: Multilayer interference pigments consisting of a transparent carrier material coated with alternating layers of metal oxides of low and high refractive index, the layers of the metal oxides of low refractive index being optically inactive.The thickness of the metal oxide layers of high refractive index is an integral multiple of the optical thickness which is necessary for the desired interference color.The layer thickness of metal oxide layers of low refractive index is from 1 to 20 nm.
    Type: Grant
    Filed: April 17, 1998
    Date of Patent: October 17, 2000
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Johann Dietz, Manfred Parusel, Matthias Schilling, Klaus Ambrosius
  • Patent number: 6132504
    Abstract: Multilayer interference pigment consisting of a central, absorbing layer and alternating layers of a material of low refractive index and of a metal or of a material of high refractive index either side of the central layer, the material of low refractive index preferably being acrylate and the metal being aluminium or chromium. The absorbing layer consists of a coating system which comprises carbon black or color-imparting absorption pigments.
    Type: Grant
    Filed: October 26, 1998
    Date of Patent: October 17, 2000
    Assignee: Merck Patent Gesellschaft mit Berschrankter Haftung
    Inventors: Matthias Kuntz, Gerhard Pfaff, Gerd Bauer, Christina Schank
  • Patent number: 6130223
    Abstract: The invention relates to thienopyrimidine of the formula (I) as well as to their physiologically acceptable salts, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, X and n have the meaning cited in claim 1. Said compounds exhibit a phosphodiesterase V inhibition and can be used in the treatment of cardiovascular dieases and for the treatment and/or therapy potency disorder.
    Type: Grant
    Filed: June 11, 1999
    Date of Patent: October 10, 2000
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Rochus Jonas, Pierre Schelling, Maria Christadler, Franz-Werner Kluxen
  • Patent number: 6129020
    Abstract: The invention relates to an air exhaust device for printing machines, tin-plate printing machines, varnishing units or the like, in particular for the removal of ink mist, having at least one exhaust element arranged above the rolls of the printing machine, which exhaust element has at least one air exhaust opening. The exhaust element (16) is arranged laterally of the rolls (4) and the air exhaust opening (14) draws the air in in approximately horizontal direction.
    Type: Grant
    Filed: April 29, 1997
    Date of Patent: October 10, 2000
    Assignee: LTG Luftechnische Gesellschaft mit beschrankter Haftung
    Inventor: Ulrich Speck
  • Patent number: 6127335
    Abstract: The invention concerns cyclopeptides of formula (I): Cyclo-(Arg-Gly-Asp-X-Y) in which X is Cha, Nal, Phe, 2-R.sup.1 -Phe, 3-R.sup.1 -Phe, 4-R.sup.1 -Phe, homo-Phe, Phg, Thi, Trp, Tyr or derivatives of Tyr, whereby the OH group can be etherified by alkyl groups containing 1-18 C-atoms and the amino-acid groups given can also be derivatives, R.sup.1 is NH.sub.2, NO.sub.2, I Br, Cl, F, alkyl with 1-18 C-atoms, Ar, Ar--O or.sup.3 H, Y is Gly in which the .alpha. N-atom may be substituted by R.sup.2 and/or the .alpha. C-atom may be substituted by R.sup.3 and/or R.sup.4, with the provision that Gly has at least one of the substituents specified, Ar is phenyl which may be substituted by one or two of groups NH.sub.2, NO.sub.2, I, Br, Cl, F, alkyl with 1-6 C-atoms or .sup.3 H, R.sup.2, R.sup.3 or R.sup.4, independently of each other, are alkyl with 1-18 C-atoms or R.sup.2 and R.sup.3 or R.sup.3 and R.sup.4 together in each case are a branched or unbranched alklyene chain with 3 to 18 C-atoms so that either the .
    Type: Grant
    Filed: April 8, 1999
    Date of Patent: October 3, 2000
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Alfred Jonczyk, Simon Goodman, Beate Diefenbach, Horst Kessler, Marcus Koppitz
  • Patent number: 6127044
    Abstract: A method for producing titanium alloy turbine blades comprising the steps of (a) forming turbine blades of titanium alloy through hot forging or machining, (b) cooling leading edges on tip portions of the turbine blades including covers thereof formed through hot forging or machining faster than blade main body after final hot forging or solid solution treatment, and (c) heat treating the cooled turbine blades. With this method, it is possible to manufacture titanium turbine blades in an economical fashion and obtain titanium alloy turbine blades superior in reliability by preventing erosion.
    Type: Grant
    Filed: June 2, 1998
    Date of Patent: October 3, 2000
    Assignees: Kabushiki Kaisha Toshiba, Boehler Schmiedetechnik Gesellschaft mit beschrankter Haftung & Company Kommandit Gesellschaft
    Inventors: Masaru Yamamoto, Hironobu Yamamoto, Herbert Puschnik, Manfred Koren
  • Patent number: 6126857
    Abstract: The invention relates to bisalkenylbicyclohexanes of the formula I ##STR1## in which R.sup.1, R.sup.2 and Z are as defined in claim 1, and to their use in liquid-crystalline media.
    Type: Grant
    Filed: October 1, 1997
    Date of Patent: October 3, 2000
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Volker Reiffenrath, Harald Hirschmann
  • Patent number: 6117920
    Abstract: The invention relates to a thermochromic polymerizable mesogenic composition essentially consisting of:a) a component MA comprising at least one achiral polymerizable mesogenic compound comprising at least one polymerizable functional group,b) a component MB comprising at least one chiral polymerizable mesogenic compound comprising at least one polymerizable functional group,c) a photoinitiator, andd) optionally a dye component,to anisotropic polymers and polymer films with a chiral mesophase obtainable from said thermochromic polymerizable mesogenic composition and to the use of said thermochromic polymerizable mesogenic composition, anisotropic polymers and polymer films for optical information storage, photomasks, decorative pigments, cosmetics, security applications, active and passive optical elements such as polarizers or optical retarders, color filters, scattering displays, adhesives or synthetic resins with anisotropic mechanical properties.
    Type: Grant
    Filed: July 12, 1999
    Date of Patent: September 12, 2000
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Emma Jolliffe, David Coates
  • Patent number: 6118043
    Abstract: The invention relates to a bone replacement material which comprises one or more polypeptides having the biological action of fibroblast growth factors in a porous matrix. The healing-in properties correspond to those of autologous bone transplantation.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 12, 2000
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Berthold Nies, Elvira Dingeldein, Helmut Wahlig
  • Patent number: 6110920
    Abstract: Thienopyrimidines of the formula I ##STR1## and the physiologically acceptable salts thereof in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, X and n have the meanings given in Claim 1inhibit phosphodiesterase V and can be employed for the treatment of diseases of the cardiovascular system and for the therapy of impaired potency.
    Type: Grant
    Filed: February 9, 1999
    Date of Patent: August 29, 2000
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Jonas Rochus, Pierre Schelling, Franz-Werner Kluxen, Maria Christadler
  • Patent number: 6110205
    Abstract: The present invention relates to porous implant materials which are loaded with an excipient/active compound combination, the excipient components used being oligomeric esters of polyhydric alcohols and .alpha.-hydroxy acids.
    Type: Grant
    Filed: June 22, 1998
    Date of Patent: August 29, 2000
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventor: Berthold Nies
  • Patent number: 6107493
    Abstract: The invention relates to a process for the preparation of cyclic perfluoroalkanebis(sulfonyl)imides and salts thereof.The new compound lithium cyclo-difluoromethanebis(sulfonyl)imide is outstandingly suitable as a conductive salt in non-aqueous electrolytes for lithium secondary batteries.
    Type: Grant
    Filed: November 12, 1998
    Date of Patent: August 22, 2000
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Ludwig Pohl, Volker Hilarius, Peter Sartori, Ralf Jueschke
  • Patent number: 6107295
    Abstract: Arylalkanoylpyridazine derivatives of the formula I ##STR1## and the physiologically acceptable salts thereof in whichR.sup.1, R.sup.2, R.sup.3, R.sup.4, Q and B have the meanings given in claim 1 act as phosphodiesterase IV inhibitors and can be employed for the treatment of osteoporosis, tumors, atherosclerosis, rheumatoid arthritis, multiple sclerosis, diabetes mellitus, inflammatory processes, allergies, asthma, autoimmune diseases and AIDS.
    Type: Grant
    Filed: February 9, 1999
    Date of Patent: August 22, 2000
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Jonas Rochus, Norbert Beier, Franz-Werner Kluxen, Michael Wolf
  • Patent number: 6099758
    Abstract: The invention relates to a broadband reflective polarizer that comprises a layer of a polymerized mesogenic material exhibiting a helically twisted molecular structure with planar alignment, said reflective polarizer being obtainable by a process wherein a mixture of a chiral polymerizable mesogenic material comprisinga) at least one achiral polymerizable mesogenic compound,b) at least one chiral compound that can in addition be polymerizable and/or mesogenic,c) a polymerization initiator,is coated on a substrate or between two substrates in form of a layer, aligned in a planar orientation so that the axis of the molecular helix extends transversely to the layer, and polymerized by exposure to heat or actinic radiation, and optionally the substrates are removed from the polymerized material, characterized in that said polymerizable material is coated and polymerized between two different substrates, and/or at least one of said substrates comprises a barrier layer on the surface adjacent to the layer of said p
    Type: Grant
    Filed: September 16, 1998
    Date of Patent: August 8, 2000
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Mark Verrall, Kim Slaney, John Philip Argent, David Coates