Patents Assigned to MITEGEN, LLC
  • Publication number: 20210195889
    Abstract: A system for cryocooling biological samples, including a first chamber configured to hold a first amount a cryogenic liquid; a container holder positioned in thermal contact with the first chamber and configured to hold at least one removable container positioned therein, wherein the container is configured to hold a second amount of the cryogenic liquid and forms a second chamber; an elongated tube holder configured to hold at least one hollow elongated tube into the container; and a sample wand configured to hold and transfer at least one sample holder with a biological sample into the elongated tube while the elongated tube is in the container with the second amount of the cryogenic liquid therein.
    Type: Application
    Filed: May 22, 2019
    Publication date: July 1, 2021
    Applicant: Mitegen, LLC
    Inventors: Robert Thorne, David Closs, Richard Jayne, Benjamin Apker
  • Publication number: 20210098226
    Abstract: A system for storing and shipping samples for cryo-electron microscopy. The system comprising a cassette puck and support platform that accepts commercial cryo-EM sample cassettes and is compatible to a substantial extent with tools used in cryocrystallography. The system can also work with existing Cryo-EM storage and transport puck and cane systems. The cassette puck comprising a receptacle for holding one or more cassettes and a plurality of holes and grooves. The holes and grooves being configured for use with other tools such as tongs, support platforms, and canes.
    Type: Application
    Filed: September 28, 2020
    Publication date: April 1, 2021
    Applicant: Mitegen, LLC
    Inventors: David Closs, Jessica Benitez, Benjamin Apker, Mazdak Radjainia
  • Patent number: 10241015
    Abstract: A method and a cryogenic sample positioning system are provided which include: a sample holder cassette that is vertically coupled to a carousel gear through a first shaft. Each sample holder cassette has a first degree of rotation about the first shaft. A first planet drive gear underlies and is vertically coupled to the carousel gear through a second shaft that extends from the carousel gear through the first planet drive gear. The carousel gear has a second degree of rotation about the second shaft that is different from the first degree of rotation. A planet gear that is laterally connected to a second planet drive gear is interposed between each of the carousel gear and the first planet drive gear. Each of the planet gear and the second planet drive gear selectively define the first degree of rotation, without affecting the second degree of rotation of the carousel gear.
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: March 26, 2019
    Assignee: Mitegen, LLC
    Inventors: Stephen Hollabaugh, Robert Newman, David Closs
  • Publication number: 20180024032
    Abstract: A method and a cryogenic sample positioning system are provided which include: a sample holder cassette that is vertically coupled to a carousel gear through a first shaft. Each sample holder cassette has a first degree of rotation about the first shaft. A first planet drive gear underlies and is vertically coupled to the carousel gear through a second shaft that extends from the carousel gear through the first planet drive gear. The carousel gear has a second degree of rotation about the second shaft that is different from the first degree of rotation. A planet gear that is laterally connected to a second planet drive gear is interposed between each of the carousel gear and the first planet drive gear. Each of the planet gear and the second planet drive gear selectively define the first degree of rotation, without affecting the second degree of rotation of the carousel gear.
    Type: Application
    Filed: July 24, 2017
    Publication date: January 25, 2018
    Applicant: Mitegen, LLC
    Inventors: Stephen Hollabaugh, Robert Newman, David Closs
  • Patent number: 9855557
    Abstract: Devices and methods for manual and high-throughput protein crystal growth and growth of other biological and organic crystals. A microplate includes a plurality of cells and a frame that defines the cells in the microplate. In each cell there is at least one well open at top. Each well in a cell may be enclosed at bottom, or it may be open at bottom, in which case the well bottom may be sealed by a separate part, which may be, e.g., a separate film or plate (e.g., of plastic, glass or metal) or a molded part.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: January 2, 2018
    Assignee: MITEGEN, LLC
    Inventors: Robert E. Thorne, Benjamin Apker, Robert Newman
  • Publication number: 20170030626
    Abstract: A cryogenic cooling manifold and methods incorporating a cryogenic cooling manifold for managing the gas layer(s) above a liquid cryogen to control cooling temperature-time profiles and ice formation for microliter and smaller samples that are plunged through the gas and into the liquid cryogen.
    Type: Application
    Filed: July 27, 2016
    Publication date: February 2, 2017
    Applicant: Mitegen, LLC
    Inventors: David Closs, Stephen Hollabaugh, Robert E. Thorne, Robert Newman, Benjamin A. Apker, Tian Xia, David Moreau
  • Publication number: 20150093306
    Abstract: Devices and methods for manual and high-throughput protein crystal growth and growth of other biological and organic crystals. A microplate includes a plurality of cells and a frame that defines the cells in the microplate. In each cell there is at least one well open at top. Each well in a cell may be enclosed at bottom, or it may be open at bottom, in which case the well bottom may be sealed by a separate part, which may be, e.g., a separate film or plate (e.g., of plastic, glass or metal) or a molded part.
    Type: Application
    Filed: March 28, 2013
    Publication date: April 2, 2015
    Applicant: MITEGEN, LLC
    Inventors: Robert E. Thorne, Benjamin Apker, Robert Newman