Abstract: Spindle for carrying out machining assisted by non-ultrasonic axial oscillations, including a tool-bearing shaft, and an exciting portion, for subjecting the shaft to non-ultrasonic axial oscillations, especially during its rotation. The exciting portion including a first exciting stage, having at least one piezoelectric actuator, and a second exciting stage, having at least one piezoelectric actuator, having a non-zero axial overlap with the first exciting stage, the actuators of the two stages being arranged so that their effects add.

Abstract: The invention refers to a replicable genetic package displaying a peptide having at least one intramolecular cyclic bond between two heteroatoms of amino acid side chains, a method of preparing a replicable genetic package, a method of producing a library and a library of replicable genetic package.

Abstract: A combustion device for an electricity production or energy cogeneration apparatus, the apparatus comprising a gas turbine supplied by the device, the device being suitable for a combustion regime of a “flameless” type, the device including: an outer tube; and a combustion tube forming a combustion zone for flameless combustion of a mixture of oxidizing air and fuel, the combustion tube being concentric with the outer tube, in communication with fuel-injection means, and with air-injection means arranged at a first end of the combustion tube, referred to as a front end, and which is closed by an end wall at a second end of the combustion tube, referred to as a rear end, the end wall being secured to the combustion tube and fluidtight, the fuel-injection means including at least a first orifice, referred to as a fuel-injection orifice, the air-injection means including at least a second orifice.

Abstract: The invention provides a replicable genetic package displaying a cyclic peptide having at least one intramolecular bond between amino acid side chains. Also provided are a method of preparing such a genetic package displaying cyclic peptides having at least one intramolecular bond. Further provided is a library of replicable genetic packages displaying cyclic peptides each having at least one intramolecular cyclic bond between amino acid side chains; and a method of producing such a library.

Abstract: An immobilizer device is provided for preventing the travel of a wheel, particularly the wheel of a vehicle. The immobilizer device utilizes an elongated pin to pass through a portion or aperture of the wheel, and the immobilizer device prevents travel of the wheel by acting as a chock. Some embodiments of the immobilizer device comprise an indexing feature to guide the elongated pin into an aperture and a receiver tube to guide the elongated pin into another aperture. Then the elongated pin may be placed in a locked position to secure the immobilizer device to the wheel.

Abstract: The present invention concerns a sealing system for a tool holder of a fluid-assisted axial machining or milling machine, including:—at least first and second seals contributing to define a space for the flow of fluid to at least one inner channel of the tool, one of the seals being applied to the tool or an optional adapter carrying the tool and the other seal a) being applied to the tool or to the adapter carrying the tool or b) being applied to a surface spaced apart from the tool and rotating with same, with 0.3?Do/Djmax for Do in the interval [1; 3] in mm and 0.5?Do/Djmax for Do in the interval [3; 20] in mm, where Do is the diameter of the tool facing this other seal and Djmax is the internal diameter of this seal.

Abstract: A machining method for at least one shaping machining operation can include carrying out a machining operation over a first distance using a cutting tool which is subjected to axial oscillations as it moves forward, then reducing the amplitude of the axial oscillations while continuing to drive the cutting tool in terms of rotation.

Abstract: The invention provides a replicable genetic package displaying a cyclic peptide having at least one intramolecular bond between amino acid side chains. Also provided are a method of preparing such a genetic package displaying cyclic peptides having at least one intramolecular bond. Further provided is a library of replicable genetic packages displaying cyclic peptides each having at least one intramolecular cyclic bond between amino acid side chains; and a method of producing such a library.

Abstract: The present invention relates to a microneedle, to a mould for producing same, and to a production method for same. More specifically, the present invention concerns a microneedle for causing a skin-beautifying substance or drug to be absorbed via the skin, to a plastic mould for producing same, and to a production method for same.

Abstract: The present invention provides an axial machining device comprising a tool-carrier spindle rotatable in a housing, the housing housing a transmission system causing the spindle to advance automatically relative to the housing under the effect of the tool-carrier spindle being driven in rotation, the transmission system including an advance gearwheel screwed onto the spindle, the device including a resilient return member urging the advance gearwheel in a first axial direction opposite to the advance direction of the spindle, and also including a first rolling bearing having rolling members rolling on an undulating raceway having an axial component, thereby periodically urging the advance gearwheel to move in a second direction opposite to the first, such that rotation of the spindle is accompanied by axial vibratory motion.

Abstract: A machining method for at least one shaping machining operation can include carrying out a machining operation over a first distance using a cutting tool which is subjected to axial oscillations as it moves forward, then reducing the amplitude of the axial oscillations while continuing to drive the cutting tool in terms of rotation

Abstract: The present invention provides an axial machining device comprising a tool-carrier spindle rotatable in a housing, the housing housing a transmission system causing the spindle to advance automatically relative to the housing under the effect of the tool-carrier spindle being driven in rotation, the transmission system including an advance gearwheel screwed onto the spindle, the device including a resilient return member urging the advance gearwheel in a first axial direction opposite to the advance direction of the spindle, and also including a first rolling bearing having rolling members rolling on an undulating raceway having an axial component, thereby periodically urging the advance gearwheel to move in a second direction opposite to the first, such that rotation of the spindle is accompanied by axial vibratory motion.

Abstract: The present invention relates to a microneedle cap system to be mounted to a container containing an active substance. The system comprises a container cap unit and a microneedle unit, which, among others, allows the active substance to be delivered in a desired amount.

Abstract: A microneedle drug delivery system comprises: a housing having an opening formed in the bottom wall thereof; a microneedle device seated in the opening of the housing in such a fashion as to be hermetically sealed with the bottom wall of the housing; a drug-containing capsule mounted in the housing 1 in such a fashion as to be positioned spaced apart from the microneedle device. With this system, an active agent (or drug) can be effectively delivered into a subject in need.

Abstract: A lancet block comprises a lancet comprising a cam projection and a lancet housing receiving the lancet in such a fashion that the lancet can be vertically moved relatively with respect to the lancet housing. A top wall of the lancet housing and a side wall of the lancet housing corresponding to the cam projection of the lancet are formed of a thin membrane made of a material capable of being easily disrupted and a bottom wall of the lancet housing is formed of a thin membrane made of a material capable of being easily disrupted by a tip of the needle of the lancet. With this lancet block, it is possible to, e.g., provide convenient and sanitary use of a lancet, avoid a risk of any injury by a needle tip, prevent bacterial infection due to such injury, and reduce manufacturing costs.

Abstract: The present invention relates to a microneedle for delivering active agent or agents. The microneedle comprises a body a body having a base at one end thereof and a tip portion at the other end thereof; a pair of projections connected to a side of the body and having a base at one end thereof and a tip portion at the other end thereof; and a vertical groove defined by the body and the pair of projections. The distance between outer edges of the pair of projections is formed to become smaller towards the tip portion than the distance between outer edges of the body, and the upper end of each of the pair of projections is shorter than that of the body such that a free space is formed between the outer edges of the body and the pair of projections.

Abstract: A container for transdermal delivery of an active agent or agents using microneedles includes a reservoir adapted to receive a substance containing an active agent or agents; and a cover member adapted to cover an entrance of the reservoir, the cover member comprising one or more through-holes formed therein and one or more microneedles formed thereon. With the container, transdermal delivery can be made conveniently, easily, and effectively.

Abstract: A microneedle-replaceable roller and stamp comprises a main body having a handle portion and a microneedle plate or sheet that is detachably mounted to the main body. According to the roller and stamp, inexpensive and sanitary application can be ensured.

Abstract: A stimuli-responsive polymer derivative utilizing keto-enol tautomerization. Also disclosed are a simple process for producing an N-acyl(meth)acrylamide derivative which can be used as a monomer for the stimuli-responsive polymer, a process for the production of an intermediate thereof, and an intermediate thus produced.