Patents Assigned to Mitobridge, Inc.
  • Crystalline and salt forms of PPAR agonist compounds
    Patent number: 11912681
    Abstract: This disclosure relates to salt forms of compounds capable of activating PPAR? for use in drug substance and drug product development, and related compositions and methods.
    Type: Grant
    Filed: December 16, 2022
    Date of Patent: February 27, 2024
    Assignee: Mitobridge, Inc.
    Inventors: Bharat Lagu, Scott Trzaska
  • ARYL ALKYNAMIDE DERIVATIVES
    Publication number: 20240018113
    Abstract: [Problem] A compound which is useful as a STING inhibitor is provided. [Means for Solution] The present inventors have found aryl alkynamide derivatives having an inhibitory action on STING. The aryl alkynamide derivatives of the present invention have an inhibitory action on STING and can be used as an agent for treating an autoimmune disease, a neurodegenerative disease, a type I interferonopathy and/or other STING-mediated disease.
    Type: Application
    Filed: September 26, 2023
    Publication date: January 18, 2024
    Applicants: Astellas Pharma, Inc., Mitobridge, Inc.
    Inventors: Junko Maeda, Ikumi Kuriwaki, Kai Kitamura, Yumi Yamashita, Kenichi Kakefuda, Akio Kamikawa, Kenji Negoro, Wataru Hamaguchi, Ryushi Seo, Jeffrey Ciavarri
  • PPAR agonists, compounds, pharmaceutical compositions, and methods of use thereof
    Patent number: 11578052
    Abstract: Provided herein are compounds and compositions useful in increasing PPAR? activity. The compounds and compositions provided herein are useful for the treatment of PPAR? related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).
    Type: Grant
    Filed: January 29, 2021
    Date of Patent: February 14, 2023
    Assignees: Mitobridge, Inc., The Salk Institute for Biological Studies
    Inventors: Michael Downes, Ronald M. Evans, Arthur Kluge, Bharat Lagu, Masanori Miura, Sunil Kumar Panigrahi, Michael Patane, Susanta Samajdar, Ramesh Senaiar, Taisuke Takahashi
  • Crystalline and salt forms of PPAR agonist compounds
    Patent number: 11530192
    Abstract: This disclosure relates to salt forms of compounds capable of activating PPAR? for use in drug substance and drug product development, and related compositions and methods.
    Type: Grant
    Filed: February 19, 2021
    Date of Patent: December 20, 2022
    Assignee: Mitobridge, Inc.
    Inventors: Bharat Lagu, Scott Trzaska
  • PPAR agonists
    Patent number: 11420934
    Abstract: Provided herein are compounds and compositions useful in increasing PPAR? activity. The compounds and compositions provided herein are useful for the treatment of PPAR? related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: August 23, 2022
    Assignees: The Salk Institute for Biological Studies, Mitobridge, Inc.
    Inventors: Ronald M. Evans, Michael Downes, Thomas J. Baiga, Joseph P. Noel, Emi Kanakubo Embler, Weiwei Fan, John F. W. Keana, Mark G. Bock, Authur F. Kluge, Mike A. Patane
  • PPAR agonists, compounds, pharmaceutical compositions, and methods of use thereof
    Patent number: 11358954
    Abstract: Provided herein are compounds and compositions useful in increasing PPAR? activity. The compounds and compositions provided herein are useful for the treatment of PPAR? related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: June 14, 2022
    Assignee: Mitobridge, Inc.
    Inventors: Bharat Lagu, Ramesh Senaiar
  • Dynamin-1-like protein inhibitors
    Patent number: 11168080
    Abstract: This application is directed to inhibitors of dynamin-1-like protein (Drp1) represented by the following structural formula (I): and methods for their use, such as to treat one or more DRP1-related diseases.
    Type: Grant
    Filed: April 25, 2018
    Date of Patent: November 9, 2021
    Assignee: Mitobridge, Inc.
    Inventors: Nan Ji, Jeyaprakash Narayanan Seenisamy
  • METHODS OF TREATING ACUTE KIDNEY INJURY
    Publication number: 20210283116
    Abstract: The present invention is directed to methods of treating a human patient with acute kidney injury.
    Type: Application
    Filed: October 5, 2017
    Publication date: September 16, 2021
    Applicants: Mitobridge, Inc., Mitobridge, Inc.
    Inventors: Bharat Lagu, Michael Patane, Effie Tozzo, Scott Trzaska
  • Poly-ADP ribose polymerase (PARP) inhibitors
    Patent number: 11034670
    Abstract: The present invention is related to a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a compound represented by the following structural formula: The present invention is also related a method of treating a subject with a disease which can be ameliorated by inhibition of poly(ADP-ribose)polymerase (PARP). The definitions of the variables are provided herein.
    Type: Grant
    Filed: December 28, 2017
    Date of Patent: June 15, 2021
    Assignee: Mitobridge, Inc.
    Inventors: Taisuke Takahashi, Arthur Kluge, Bharat Lagu, Nan Ji
  • USP30 inhibitors
    Patent number: 10968172
    Abstract: The application relates to phenyl- or naphthylsulfonamide derivatives of the structural formula (I). The compounds are described as inhibitors of USP30 (ubiquitin specific peptidase 30) useful for the treatment of conditions involving mitochondrial defects including neurodegenerative diseases such as Alzheimer's and Parkinson's or a neoplastic disease such as leukemia.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: April 6, 2021
    Assignee: Mitobridge, Inc.
    Inventors: Arthur Kluge, Bharat Lagu, Pranab Maiti, Sunil Kumar Panigrahi
  • Crystalline and salt forms of PPAR agonist compounds
    Patent number: 10927094
    Abstract: This disclosure relates to salt forms of compounds capable of activating PPAR? for use in drug substance and drug product development, and related compositions and methods.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: February 23, 2021
    Assignee: Mitobridge, Inc.
    Inventors: Bharat Lagu, Scott Trzaska
  • PPAR agonists, compounds, pharmaceutical compositions, and methods of use thereof
    Patent number: 10906885
    Abstract: Provided herein are compounds and compositions useful in increasing PPAR? activity. The compounds and compositions provided herein are useful for the treatment of PPAR? related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).
    Type: Grant
    Filed: November 13, 2019
    Date of Patent: February 2, 2021
    Assignees: Mitobridge, Inc., The Salk Institute for Biological Studies
    Inventors: Michael Downes, Ronald M. Evans, Arthur Kluge, Bharat Lagu, Masanori Miura, Sunil Kumar Panigrahi, Michael Patane, Susanta Samajdar, Ramesh Senaiar, Taisuke Takahashi
  • Methods of treating acute kidney injury
    Patent number: 10874641
    Abstract: The present invention also contemplates a method of treating a human patient with acute kidney injury or reducing the likelihood of developing acute kidney injury in a human patient at risk of developing acute kidney injury comprising administering to the patient a poly-ADP ribose polymerase (PARP) inhibitor in a therapeutically effective dose so as to thereby treat the patient.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: December 29, 2020
    Assignee: Mitobridge, Inc.
    Inventors: Eric Bell, Nan Ji, Dominique Stickens, Taisuke Takahashi, Effie Tozzo
  • PPAR AGONISTS, COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF
    Publication number: 20200347037
    Abstract: Provided herein are compounds and compositions useful in increasing PPAR? activity. The compounds and compositions provided herein are useful for the treatment of PPAR? related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).
    Type: Application
    Filed: April 13, 2017
    Publication date: November 5, 2020
    Applicant: Mitobridge, Inc.
    Inventors: Bharat LAGU, Ramesh SENAIAR
  • HMOX1 inducers
    Patent number: 10766888
    Abstract: The present invention is related to compounds of structure (I) as heme oxygenase 1 (HMOX 1) inducers. The present invention is also related a method of controlling the activity or the amount, or both the activity and the amount, of heme-oxygenase 1 in a mammalian subject. The definitions of the variables are provided herein.
    Type: Grant
    Filed: April 8, 2020
    Date of Patent: September 8, 2020
    Assignee: Mitobridge Inc.
    Inventors: Margaret Biddle, Arthur Kluge, Sanjita Sasmal, Bharat Lagu, Xinyuan Wu, Takashi Ogiyama, Eric Bell
  • PPAR AGONISTS
    Publication number: 20200190019
    Abstract: Provided herein are compounds and compositions useful in increasing PPAR? activity. The compounds and compositions provided herein are useful for the treatment of PPAR? related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).
    Type: Application
    Filed: December 16, 2019
    Publication date: June 18, 2020
    Applicants: Salk Institute for Biological Studies, Mitobridge, Inc.
    Inventors: Ronald M. Evans, Michael Downes, Thomas J. Baiga, Joseph P. Noel, Emi Kanakubo Embler, Weiwei Fan, John F.W. Keana, Mark G. Bock, Authur F. Kluge, Mike A. Patane
  • Nicotinamide riboside and nicotinamide mononucleotide derivatives for use in the treatments of mitochondrial-related diseases
    Patent number: 10611790
    Abstract: Provided herein are compounds of Formula (I): or a pharmaceutically acceptable salt thereof, and compositions comprising such compounds that are useful for increasing the amount of NAD+ in cells. Also disclosed are methods of using the disclosed compounds and compositions for treating mitochondrial-related diseases or disorders.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: April 7, 2020
    Assignee: Mitobridge, Inc.
    Inventors: Arthur Kluge, Nan Ji
  • PPAR agonists
    Patent number: 10550071
    Abstract: Provided herein are compounds and compositions useful in increasing PPAR? activity. The compounds and compositions provided herein are useful for the treatment of PPAR? related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: February 4, 2020
    Assignees: Salk Institute for Biological Studies, Mitobridge, Inc.
    Inventors: Ronald M. Evans, Michael Downes, Thomas J. Baiga, Joseph P. Noel, Emi Kanakubo Embler, Weiwei Fan, John F. W. Keana, Mark G. Bock, Arthur F. Kluge, Mike A. Patane
  • PPAR agonists, compounds, pharmaceutical compositions, and methods of use thereof
    Patent number: 10479775
    Abstract: Provided herein are compounds and compositions useful in increasing PPAR? activity. The compounds and compositions provided herein are useful for the treatment of PPAR? related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: November 19, 2019
    Assignees: Mitobridge, Inc., The Salk Institute for Biological Studies
    Inventors: Michael Downes, Ronald M. Evans, Arthur Kluge, Bharat Lagu, Masanori Miura, Sunil Kumar Panigrahi, Michael Patane, Susanta Samajdar, Ramesh Senaiar, Taisuke Takahashi
  • PPAR agonists, compounds, pharmaceutical compositions, and methods of use thereof
    Patent number: 10399958
    Abstract: Provided herein are compounds I, II or III and compositions useful in increasing PPAR8 activity. The compounds and compositions provided herein are useful for the treatment of PPAR8 related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).
    Type: Grant
    Filed: October 5, 2016
    Date of Patent: September 3, 2019
    Assignees: Mitobridge, Inc., The Salk Institute for Biological Studies
    Inventors: Michael Downes, Ronald M. Evans, Arthur Kluge, Bharat Lagu, Masanori Miura, Sunil Kumar Panigrahi, Michael Patane, Susanta Samajdar, Ramesh Senaiar, Taisuke Takahashi