Abstract: The invention relates to the manufacturing and use of pharmaceutical compositions of medicines (ophthalmic preparations) comprising a mitochondria-addressed antioxidant and a set of auxiliary substances providing effective treatment for ophthalmological diseases in humans and animals.
Abstract: The present disclosure provides methods of preventing activation of neutrophils with mitochondrially targeted antioxidants. Also disclosed are methods of preventing or treating different inflammatory diseases and inflammation-related conditions with MTAs.
Type:
Grant
Filed:
January 21, 2014
Date of Patent:
August 29, 2017
Assignee:
MITOTECH SA
Inventors:
Maxim V Skulachev, Vladimir P. Skulachev, Egor Y Plotnikov, Dmitry B Zorov, Roman A Zinovkin, Alexander N Lukashev, Maxim V Egorov, Maxim L Lovat, Anton Petrov
Abstract: The invention relates to the manufacturing and use of pharmaceutical compositions of medicines (ophthalmic preparations) comprising a mitochondria-addressed antioxidant and a set of auxiliary substances providing effective treatment for ophtalmological diseases in humans and animals.
Abstract: Provided are stable liquid and solid formulations of oxidized and reduced mitochondria-targeted antioxidants, and methods of their preparation and use.
Type:
Grant
Filed:
October 20, 2015
Date of Patent:
February 21, 2017
Assignee:
MITOTECH SA
Inventors:
Maxim V. Skulachev, Vladimir P. Skulachev, Audrey A. Zamyatnin, Vadim N. Tashlitsky, Roman A. Zinovkin, Maxim V. Egorov, Lawrence T. Friedhoff, Olga Y. Pletushkina, Alexander A. Andreev-Andrievsky, Tatiana V. Zinevich
Abstract: The present invention relates to pharmacology, medicine, ophthalmology, and, in particular, concerns a class of chemical compounds of structure (I) and also their solvates, isomers or prodrugs applicable when incorporated into pharmaceutical compositions also containing pharmaceutically acceptable carrier which can be useful for prophylaxis and treatment of different eye pathologies such as cataract and macular dystrophy.
Type:
Grant
Filed:
January 24, 2014
Date of Patent:
February 21, 2017
Assignee:
MITOTECH SA
Inventors:
Vladimir P. Skulachev, Maxim V. Skulachev
Abstract: The invention relates to pharmacology, medicine and gerontology, in particular to a class of chemical structures (1) which can be used in compositions, in the form of geroprotectors, for extending the life time, decelerating, stopping or for reversing the process of the entirety of the organism's dysfunctions causing the mammal ageing and for preventing and treating particular senile diseases.
Type:
Grant
Filed:
April 11, 2007
Date of Patent:
September 13, 2016
Assignee:
MITOTECH SA
Inventors:
Maxim V. Skulachev, Vladimir P. Skulachev
Abstract: This invention relates to biology and medicine and in particular it can be used in medicine for preparation of pharmaceutical composition that can accelerate wound healing by means of directed transport of biologically active substances (bioactive compounds) to the mitochondria, using hydrogen electrochemical potential in mitochondria. Besides, this invention relates to a certain method of influencing on the organism by means of said directed transport of required biologically active substances.
Type:
Grant
Filed:
January 29, 2007
Date of Patent:
August 30, 2016
Assignee:
MITOTECH SA
Inventors:
Vladimir P. Skulachev, Maxim V. Skulachev
Abstract: This invention relates to biology and medicine and, in particular, can be used in medicine to make a pharmaceutical composition for targeted delivery of biologically active substances into mitochondria, driven by proton electro-chemical potential in the mitochondria. This invention also relates to the method to affect an organism by the targeted delivery of biologically active compounds to mitochondria. The invention can be useful in treatment of diseases or disorders associated with not normal functioning of mitochondria, in particular diseases associated with increased production of free radicals and reactive oxygen species.
Abstract: The present disclosure provides purified pharmaceutical preparations comprising oxidized SkQ1, wherein no individual impurity exceeds 1.5%, the total impurity content of the preparation does not exceed 4.
Type:
Grant
Filed:
May 14, 2012
Date of Patent:
January 12, 2016
Assignee:
Mitotech SA
Inventors:
Maxim V. Skulachev, Vladimir P. Skulachev, Andrei A. Zamyatin, Evgeny S. Efremov, Vadim N. Tashlitsky, Lev S. Yaguzhinsky, Galina A. Korshunova, Natalya V. Sumbatyan, Yury N. Antonenko, Inna I. Severina, Boris V. Chernyak
Abstract: Provided are stable liquid and solid formulations of oxidized and reduced mitochondria-targeted antioxidants, and methods of their preparation and use.
Type:
Grant
Filed:
June 4, 2012
Date of Patent:
November 24, 2015
Assignee:
MITOTECH SA
Inventors:
Maxim V. Skulachev, Vladimir P. Skulachev, Andrey A. Zamyatnin, Eugeny S. Efremov, Innokentiy V. Skulachev, Vadim N. Tashlitsky, Roman A. Zinovkin, Maxim V. Egorov, Lawrence T. Friedhoff, Olga Y. Pletushkina, Alexander A. Andreev-Andrievsky, Tatiana V. Zinevich
Abstract: Provided are stable liquid and solid formulations of oxidized and reduced mitochondria-targeted antioxidants, and methods of their preparation and use.
Type:
Application
Filed:
June 4, 2012
Publication date:
January 22, 2015
Applicant:
Mitotech SA
Inventors:
Maxim V. Skulachev, Vladimir P. Skulachev, Andrey A. Zamyatnin, Vadim N. Tashlitsky, Roman A. Zinovkin, Maxim V. Egorov, Lawrence T. Friedhoff, Olga Y. Pletushkina, Alexander A. Andreev-Andrievsky, Tatiana V. Zinevich
Abstract: The present invention relates to pharmacology, medicine, ophthalmology, and, in particular, concerns a class of chemical compounds of structure (I) and also their solvates, isomers or prodrugs applicable when incorporated into pharmaceutical compositions also containing pharmaceutically acceptable carrier which can be useful for prophylaxis and treatment of different eye pathologies such as cataract and macular dystrophy.
Type:
Application
Filed:
January 24, 2014
Publication date:
May 22, 2014
Applicant:
MITOTECH SA
Inventors:
Vladimir P. SKULACHEV, Maxim V. Skulachev
Abstract: The present invention relates to pharmacology, medicine, opthalmology, and, in particular, concerns a class of chemical compounds of structure (I) and also their solvates, isomers or prodrugs applicable when incorporated into pharmaceutical compositions also containing pharmaceutically acceptable carrier which can be useful for prophylaxis and treatment of different eye pathologies such as cataract and macular dystrophy.
Type:
Grant
Filed:
October 20, 2006
Date of Patent:
February 25, 2014
Assignee:
Mitotech SA
Inventors:
Vladimir P. Skulachev, Maxim V. Skulachev
Abstract: The invention relates to pharmacology and medicine, in particular to a class of mitochondrially-addressed compounds which can be used in the pharmaceutical compositions of medicinal agents (preparations) for preventing and treating cardiovascular diseases and diseases and pathological conditions caused by disturbed blood circulation or oxygen supply to tissues and organs.
Type:
Application
Filed:
July 25, 2013
Publication date:
December 19, 2013
Applicant:
Mitotech SA
Inventors:
Maxim V. Skulachev, Vladimir P. Skulachev
Abstract: The invention relates to pharmacology and medicine, in particular to a class of mitochondrially-addressed compounds which can be used in the pharmaceutical compositions of medicinal agents (preparations) for preventing and treating cardiovascular diseases and diseases and pathological conditions caused by disturbed blood circulation or oxygen supply to tissues and organs.
Type:
Grant
Filed:
June 29, 2007
Date of Patent:
August 27, 2013
Assignee:
Mitotech SA
Inventors:
Maxim Vladimirovich Skulachev, Vladimir Petrovich Skulachev
Abstract: Disclosed is a method of treating a cancer on a mammal, comprising administering to the mammal in need thereof a therapeutically effective amount of a compound
Abstract: The invention relates to pharmacology, medicine and oncology, in particular, to a class of chemical compounds, the structure of which corresponds to formula (I) and which can be used in pharmaceutical compositions for preventing and treating an extended range of oncological diseases, including, in the form of an anti-tumoral preparation and a preparation which is used for combined therapy of oncological diseases.
Type:
Grant
Filed:
January 29, 2007
Date of Patent:
January 8, 2013
Assignee:
Mitotech SA
Inventors:
Vladimir P. Skulachev, Maxim V. Skulachev
Abstract: This invention relates to the fields of pharmaceutics and medicine, and, in particular, relates to the production and use of pharmaceutical substances on the basis of mitochondria-addressed compounds. The invention discloses methods for synthesis, purification and storage of mitochondria-addressed antioxidants, making it possible to produce said substances in a form and quality meeting the demands made on active ingredients of medicinal preparations—the pharmaceutical substances. The invention also discloses methods for design and selection of new mitochondria-addressed antioxidants having specified properties.
Type:
Application
Filed:
May 14, 2012
Publication date:
October 11, 2012
Applicant:
MITOTECH SA
Inventors:
Maxim V. Skulachev, Vladimir P. Skulachev, Andrei A. Zamyatin, Evgeny S. Efremov, Vadim N. Tashlitsky, Lev S. Yaguzhinsky, Galina A. Korshunova, Natalya V. Sumbatyan, Yury N. Antonenko, Inna I. Severina, Boris V. Chernyak
Abstract: The invention relates to the manufacturing and use of pharmaceutical compositions of medicines (ophthalmic preparations) comprising a mitochondria-addressed antioxidant and a set of auxiliary substances providing effective treatment for ophtalmological diseases in humans and animals.