Abstract: The present invention provides a novel a condensed polycyclic compound useful as a phosphodiesterase 4 inhibitor, which is shown by the formula [I]: or a pharmaceutically acceptable salt thereof and a pharmaceutical composition containing the same.
Type:
Grant
Filed:
September 6, 2006
Date of Patent:
June 23, 2009
Assignee:
Mitsubishi Tanbe Pharma Corporation
Inventors:
Tatsuzo Ukita, Yoshihiro Terakawa, Kazuteru Wada, Aya Nakata, Atsuko Sakai, Koji Ogawa
Abstract: The present invention provides a process for preparing a novel phenylalanine derivative of the formula (I): wherein X1 is a halogen atom, X2 is a halogen atom, Q is a group of the formula βCH2β or β(CH2)2β and Y is a lower alkyl group, or a pharmaceutically acceptable salt thereof, which has excellent inhibitory effects on ?4 integrin-mediated cell adhesion, and an intermediate useful in the process.