Abstract: This invention relates generally to N-benzylamino cyclic thioureas, pharmaceutical compositions containing them, and their use as antagonists of melanin-concentrating hormone receptor (MCH receptor).
Type:
Grant
Filed:
March 23, 2005
Date of Patent:
February 12, 2013
Assignees:
Mixture Sciences, Inc., The Regents of the University of California
Inventors:
Richard A. Houghten, Colette Dooley, Adel Nefzi, Zhiwei Wang, Oliver Civelli, Hiroshi Nagasaki
Abstract: A solid phase synthetic method is disclosed in which the usual solid phase synthetic steps are carried out and the spent solid phase support is reacted to form a volatilizable compound upon cleavage of the reaction product from the solid phase support. The cleaved product is then separated from the volatile compound by volatilization of that compound. Exemplary solid supports that form a volatilizable compound are also disclosed.
Type:
Grant
Filed:
June 26, 2006
Date of Patent:
July 8, 2008
Assignee:
Mixture Sciences, Inc.
Inventors:
Jeanick H. Pascal, Michael J. Moran, Richard A. Houghten
Abstract: A solid phase synthetic method is disclosed in which the usual solid phase synthetic steps are carried out and the spent solid phase support is reacted to form a volatilizable compound upon cleavage of the reaction product from the solid phase support. The cleaved product is then separated from the volatile compound by volatilization of that compound. Exemplary solid supports that form a volatilizable compound are also disclosed.
Type:
Application
Filed:
June 26, 2006
Publication date:
October 26, 2006
Applicant:
Mixture Sciences, Inc.
Inventors:
Jeanick Pascal, Michael Moran, Richard Houghten
Abstract: A solid phase synthetic method is disclosed in which the usual solid phase synthetic steps are carried out and the spent solid phase support is reacted to form a volatilizable compound upon cleavage of the reaction product from the solid phase support. The cleaved product is then separated from the volatile compound by volatilization of that compound. Exemplary solid supports that form a volatilizable compound are also disclosed.
Type:
Grant
Filed:
November 1, 2002
Date of Patent:
June 27, 2006
Assignee:
Mixture Sciences, Inc.
Inventors:
Jeanick H. Pascal, Michael J. Moran, Richard A. Houghten
Abstract: A solid phase synthetic method is disclosed in which the usual solid phase synthetic steps are carried out and the spent solid phase support is reacted to form a volatilizable compound upon cleavage of the reaction product from the solid phase support. The cleaved product is then separated from the volatile compound by volatilization of that compound. Exemplary solid supports that form a volatilizable compound are also disclosed.
Type:
Grant
Filed:
January 28, 2000
Date of Patent:
November 5, 2002
Assignee:
Mixture Sciences, Inc.
Inventors:
Jeanick H. Pascal, Michael J. Moran, Richard A. Houghten