Patents Assigned to Miyazaki Prefectural Industrial Support Foundation
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Patent number: 8263347Abstract: Disclosed are: a marker for the diagnosis of a liver disease, which can determine the disease in a simple manner; an antibody directed against the marker; a diagnostic agent; a diagnosis method; and a method for marker detection in blood or serum. Proteome analysis revealed that quantities of the full-length kininogen and three partial peptides thereof (sequence A: position-440 to position-456, sequence B: position-439 to position-456, and sequence C: position-438 to position-456) in sera of patients with non-alcoholic fatty liver disease are significantly different from those in sera of healthy individuals; and a diagnostic agent and a detecting method for the non-alcoholic fatty liver disease that can be conveniently used for medical examination are established.Type: GrantFiled: October 20, 2008Date of Patent: September 11, 2012Assignees: Miyazaki Prefectural Industrial Support Foundation, Kagoshima University, Chugai Seiyaku Kabushiki KaishaInventors: Hirohito Tsubouchi, Hirofumi Uto, Takeshi Okanoue, Yo-ichi Ishida, Yuko Sato, Masayuki Sudo
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Publication number: 20120107299Abstract: Provided is a preventive, progression inhibitor or remedy for a disease one of the causes of which is the activation of the P13K/AKT signaling pathway or vice versa. A phosphorylation-inhibiting and/or dephosphorylating agent, which has an effect of inhibiting the phosphorylation at least at one of the phosphorylation sites of PTEN protein selected from the group consisting of T382, T383 and S380 and/or an effect of dephosphorylating the same, is prepared. Alternatively, a phosphorylation-inhibiting or dephosphorylating agent for PTEN is screened by a method comprising a step for confirming an ability of a test substance to inhibit the phosphorylation at least at one of the phosphorylation sites of PTEN protein selected from the group consisting of T382, T383 and S380 or a dephosphorylation ability thereof. Then, a substance having an effect opposite to the inhibition of PTEN phosphorylation or dephosphorylation thereof, e.g.Type: ApplicationFiled: March 26, 2010Publication date: May 3, 2012Applicants: MIYAZAKI PREFECTURAL INDUSTRIAL SUPPORT FOUNDATION, UNIVERSITY OF MIYAZAKIInventors: Kazuhiro Morishita, Shingo Nakahata, Makoto Hamasaki
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Publication number: 20110288164Abstract: This invention provides an agent for inhibiting production of hepatitis C virus with notable anti-HCV activity and without side-effects. The agent comprises a proanthocyanidin polymer composition illustrated in the following the general formula (1), wherein R1 is hydrogen or hydroxyl, R2 is hydroxyl, R3 is hydrogen when R1 is either hydrogen or hydroxyl, but R3 is possibly hydroxyl when R1 is either hydrogen or hydroxyl to the extent that both R1 and R3 being hydroxyl is at most 40 percents in the proanthocyanidin polymer composition said units of flavan-3-ol being bonded each other in any one of three patterns as follows; (i) a bond between carbon at the position 4 and carbon at the position 8, (ii) a bond between carbon at the position 4 and carbon at the position 6, (iii) a bond between carbon at the position 4 and carbon at the position 8, and between carbon, at the position 2 and oxygen at the position 7.Type: ApplicationFiled: August 5, 2011Publication date: November 24, 2011Applicants: MIYAZAKI PREFECTURAL INDUSTRIAL SUPPORT FOUNDATION, MINAMI NIPPON DAIRY CO-OP CO., LTD., UNKAI SHUZO CO., LTD., MIYAZAKI PREFECTUREInventors: Masahiko TAKESHITA, Hirohito TSUBOUCHI, Hirofumi UTO, Hiroaki KATAOKA, Takanori KAI, Hideaki HIRABARU, Miho SAKAI, Ena AKAMATSU
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Publication number: 20100055065Abstract: This invention provides an agent for inhibiting production of hepatitis C virus with notable anti-HCV activity and without side-effects. The agent comprises a proanthocyanidin polymer composition illustrated in the following the general formula (1), wherein R1 is hydrogen or hydroxyl, R2 is hydroxyl, R3 is hydrogen when R1 is either hydrogen or hydroxyl, but R3 is possibly hydroxyl when R1 is either hydrogen or hydroxyl to the extent that both R1 and R3 being hydroxyl is at most 40 percents in the proanthocyanidin polymer composition said units of flavan-3-ol being bonded each other in any one of three patterns as follows; (i) a bond between carbon at the position 4 and carbon at the position 8, (ii) a bond between carbon at the position 4 and carbon at the position 6, (iii) a bond between carbon at the position 4 and carbon at the position 8, and between carbon at the position 2 and oxygen at the position 7.Type: ApplicationFiled: August 24, 2009Publication date: March 4, 2010Applicants: MIYAZAKI PREFECTURAL INDUSTRIAL SUPPORT FOUNDATION, MIYAZAKI PREFECTURE, UNKAI SHUZO CO., LTD., MINAMI NIPPON DAIRY CO-OP CO., LTD.Inventors: Masahiko TAKESHITA, Hirohito TSUBOUCHI, Hirofumi UTO, Hiroaki KATAOKA, Takanori KAI, Hideaki HIRABARU, Miho SAKAI, Ena AKAMATSU