Patents Assigned to Miyazaki Prefecture
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Publication number: 20220026403Abstract: A supercritical fluid chromatograph includes a liquid sender that supplies a mobile phase including a supercritical fluid to a supply flow path, first and second back pressure regulators that are respectively provided in first and second flow paths into which a path from the liquid sender branches and an analysis column provided at a position farther upstream than the first back pressure regulator in the first flow path.Type: ApplicationFiled: July 20, 2021Publication date: January 27, 2022Applicants: SHIMADZU CORPORATION, MIYAZAKI PREFECTURE, KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATIONInventors: Yuka FUJITO, Miho SAKAI, Takeshi BAMBA
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Patent number: 10441935Abstract: Provided is a method suitable for industrial-scale production of a dispersion in which nano-sized particles are dispersed. Specifically, a method for producing a nanoparticle-in-oil dispersion in which fine particles made up of a solid component, an aqueous liquid component or a mixture thereof are dispersed in an oil phase, includes: (1) a step of preparing a W/O emulsion-type precursor in which an aqueous phase in the form of droplets of an aqueous solution having a water-soluble substance dissolved therein is dispersed in an oil phase; and (2) a step of boiling the aqueous phase of the W/O emulsion-type precursor, to obtain a nanoparticle-in-oil dispersion in which the fine particles are dispersed in the oil phase.Type: GrantFiled: January 17, 2016Date of Patent: October 15, 2019Assignee: MIYAZAKI PREFECTUREInventors: Masataka Shimizu, Kenji Yamamoto, Shingo Hamayama
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Patent number: 9023343Abstract: Provided is a preventive, progression inhibitor or remedy for a disease one of the causes of which is the activation of the P13K/AKT signaling pathway or vice versa. A phosphorylation-inhibiting and/or dephosphorylating agent, which has an effect of inhibiting the phosphorylation at least at one of the phosphorylation sites of PTEN protein selected from the group consisting of T382, T383 and S380 and/or an effect of dephosphorylating the same, is prepared. Alternatively, a phosphorylation-inhibiting or dephosphorylating agent for PTEN is screened by a method comprising a step for confirming an ability of a test substance to inhibit the phosphorylation at least at one of the phosphorylation sites of PTEN protein selected from the group consisting of T382, T383 and S380 or a dephosphorylation ability thereof. Then, a substance having an effect opposite to the inhibition of PTEN phosphorylation or dephosphorylation thereof, e.g.Type: GrantFiled: March 26, 2010Date of Patent: May 5, 2015Assignee: Miyazaki PrefectureInventors: Kazuhiro Morishita, Shingo Nakahata, Makoto Hamasaki
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Patent number: 8846751Abstract: This invention provides an agent for inhibiting production of hepatitis C virus with notable anti-HCV activity and without side-effects. The agent comprises a proanthocyanidin polymer composition illustrated in the following the general formula (1), wherein R1 is hydrogen or hydroxyl, R2 is hydroxyl, R3 is hydrogen when R1 is either hydrogen or hydroxyl, but R3 is possibly hydroxyl when R1 is either hydrogen or hydroxyl to the extent that both R1 and R3 being hydroxyl is at most 40 percents in the proanthocyanidin polymer composition said units of flavan-3-ol being bonded each other in any one of three patterns as follows; (i) a bond between carbon at the position 4 and carbon at the position 8, (ii) a bond between carbon at the position 4 and carbon at the position 6, (iii) a bond between carbon at the position 4 and carbon at the position 8, and between carbon, at the position 2 and oxygen at the position 7.Type: GrantFiled: August 5, 2011Date of Patent: September 30, 2014Assignees: Miyazaki Enterprise Promotion Organization, Miyazaki Prefecture, Unkai Shuzo Co., Ltd., Minami Nippon Dairy Co-Op Co., Ltd.Inventors: Masahiko Takeshita, Hirohito Tsubouchi, Hirofumi Uto, Hiroaki Kataoka, Takanori Kai, Hideaki Hirabaru, Miho Sakai, Ena Akamatsu
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Publication number: 20120244602Abstract: A method for culturing cells or microorganisms by dissolving oxygen or carbon dioxide in a culture solution containing a nutrient including: supplying gas containing oxygen or carbon dioxide into inside of a glass porous body being configured to have cylindrical shape and a large number of uniformly fine pores in the outer surface and being configured to seal the end of the glass porous body; generating bubbles that have a 50% diameter of 200 ?m or less in a volume-based particle size distribution from the outer surface of the porous body by using gas containing oxygen or carbon dioxide that is supplied from an unsealed end of the glass porous body; suppressing aggregation of the bubbles by at least one of a cell-protecting agent for protecting the cells and a protein hydrolysate included in the culture solution; and dissolving oxygen or carbon dioxide in the culture solution.Type: ApplicationFiled: May 31, 2012Publication date: September 27, 2012Applicants: MIYAZAKI PREFECTURE, JGC CORPORATIONInventors: Taisei OKUMURA, Mamoru NUMATA, Shuzo KOJIMA, Yasuhisa NAGATA, Naoki TAHARA, Hiroyuki KUROKI, Masato KUKIZAKI, Tomohiro TANAKA
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Publication number: 20110288164Abstract: This invention provides an agent for inhibiting production of hepatitis C virus with notable anti-HCV activity and without side-effects. The agent comprises a proanthocyanidin polymer composition illustrated in the following the general formula (1), wherein R1 is hydrogen or hydroxyl, R2 is hydroxyl, R3 is hydrogen when R1 is either hydrogen or hydroxyl, but R3 is possibly hydroxyl when R1 is either hydrogen or hydroxyl to the extent that both R1 and R3 being hydroxyl is at most 40 percents in the proanthocyanidin polymer composition said units of flavan-3-ol being bonded each other in any one of three patterns as follows; (i) a bond between carbon at the position 4 and carbon at the position 8, (ii) a bond between carbon at the position 4 and carbon at the position 6, (iii) a bond between carbon at the position 4 and carbon at the position 8, and between carbon, at the position 2 and oxygen at the position 7.Type: ApplicationFiled: August 5, 2011Publication date: November 24, 2011Applicants: MIYAZAKI PREFECTURAL INDUSTRIAL SUPPORT FOUNDATION, MINAMI NIPPON DAIRY CO-OP CO., LTD., UNKAI SHUZO CO., LTD., MIYAZAKI PREFECTUREInventors: Masahiko TAKESHITA, Hirohito TSUBOUCHI, Hirofumi UTO, Hiroaki KATAOKA, Takanori KAI, Hideaki HIRABARU, Miho SAKAI, Ena AKAMATSU
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Patent number: 7976608Abstract: In a solder paste which is a mixture of a flux and low melting point metal particles, low melting point metal fine particles manufactured by a conventional method or apparatus therefor include particles having widely varying particle diameters. Accordingly, the solder paste could not completely fill the minute holes in a mask for application to minute solder portions by printing, or mask removability was poor. According to the present invention, a mixture of a heat resistant continuous phase liquid and coarse metal particles in molten state is passed through a porous membrane to form the coarse low melting point metal particles into fine particles with a predetermined diameter. An apparatus according to the present invention comprise a porous membrane between a heating and dispersing mechanism and a cooling mechanism, and a pressure vessel connected to the heating and dispersing mechanism for applying a high pressure to the heating and dispersing mechanism.Type: GrantFiled: March 9, 2005Date of Patent: July 12, 2011Assignees: Senju Metal Industry Co., Ltd., Miyazaki PrefectureInventors: Kiyoshi Torigoe, Masataka Shimizu, Kenji Yamamoto, Mitsuhiro Mizozoe, Hoshiro Takahashi, Tomohide Suzuki, Motohiro Murase
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Publication number: 20100055065Abstract: This invention provides an agent for inhibiting production of hepatitis C virus with notable anti-HCV activity and without side-effects. The agent comprises a proanthocyanidin polymer composition illustrated in the following the general formula (1), wherein R1 is hydrogen or hydroxyl, R2 is hydroxyl, R3 is hydrogen when R1 is either hydrogen or hydroxyl, but R3 is possibly hydroxyl when R1 is either hydrogen or hydroxyl to the extent that both R1 and R3 being hydroxyl is at most 40 percents in the proanthocyanidin polymer composition said units of flavan-3-ol being bonded each other in any one of three patterns as follows; (i) a bond between carbon at the position 4 and carbon at the position 8, (ii) a bond between carbon at the position 4 and carbon at the position 6, (iii) a bond between carbon at the position 4 and carbon at the position 8, and between carbon at the position 2 and oxygen at the position 7.Type: ApplicationFiled: August 24, 2009Publication date: March 4, 2010Applicants: MIYAZAKI PREFECTURAL INDUSTRIAL SUPPORT FOUNDATION, MIYAZAKI PREFECTURE, UNKAI SHUZO CO., LTD., MINAMI NIPPON DAIRY CO-OP CO., LTD.Inventors: Masahiko TAKESHITA, Hirohito TSUBOUCHI, Hirofumi UTO, Hiroaki KATAOKA, Takanori KAI, Hideaki HIRABARU, Miho SAKAI, Ena AKAMATSU
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Patent number: 7591452Abstract: The invention provides a method for producing bubbles that exhibit an excellent monodispersity. The invention relates to a method for generating bubbles by the injection and dispersion of a gas through a porous body into a liquid, wherein the value produced by dividing the pore diameter that accounts for 10% of the total pore volume in the relative cumulative pore distribution curve of the porous body by the pore diameter that accounts for 90% of the total pore volume in the relative cumulative pore dismeter distribution curve of the porous body is 1 to 1.5.Type: GrantFiled: December 13, 2004Date of Patent: September 22, 2009Assignees: Miyazaki PrefectureInventors: Yasuaki Kohama, Masato Kukizaki, Tadao Nakashima
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Patent number: 7291200Abstract: It is an object of the present invention to provide spherical metal particles having excellent monodispersity. The present invention relates to a method of manufacturing monodisperse spherical metal particles characterized by passing liquid metal through a porous membrane so as to disperse the resulting liquid metal particles in a continuous liquid phase.Type: GrantFiled: January 26, 2005Date of Patent: November 6, 2007Assignee: Miyazaki PrefectureInventors: Masataka Shimizu, Kiyoshi Torigoe, Tadao Nakashima, Izumi Akazaki
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Publication number: 20060284325Abstract: The invention provides a method for producing bubbles that exhibit an excellent monodispersity. The invention relates to a method for generating bubbles by the injection and dispersion of a gas through a porous body into a liquid, wherein the value produced by dividing the pore diameter that accounts for 10% of the total pore volume in the relative cumulative pore distribution curve of the porous body by the pore diameter that accounts for 90% of the total pore volume in the relative cumulative pore dismeter distribution curve of the porous body is 1 to 1.5.Type: ApplicationFiled: December 13, 2004Publication date: December 21, 2006Applicants: Miyazaki Prefecture, Yasuaki KohamaInventors: Yasuaki Kohama, Masato Kukizaki, Tadao Nakashima
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Publication number: 20060094679Abstract: An object of the present invention is to provide a method of preventing or treating liver disease, particularly non-alcoholic fatty liver disease, hepatic fibrosis, cirrhosis, or liver cancer. The present invention is directed to a method of preventing or treating liver disease comprising administering to a patient in need thereof an effective amount of an osteoactivin-like protein or a fragment thereof having liver disease-suppressing activity similar to that of osteoactivin or a gene comprising a DNA encoding such a protein or fragment.Type: ApplicationFiled: August 23, 2005Publication date: May 4, 2006Applicant: MIYAZAKI PREFECTUREInventors: Hirohito Tsubouchi, Satoru Hasuike
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Publication number: 20050126339Abstract: It is an object of the present invention to provide spherical metal particles having excellent monodispersity. The present invention relates to a method of manufacturing monodisperse spherical metal particles characterized by passing liquid metal through a porous membrane so as to disperse the resulting liquid metal particles in a continuous liquid phase.Type: ApplicationFiled: January 26, 2005Publication date: June 16, 2005Applicant: Miyazaki PrefectureInventors: Masataka Shimizu, Kiyoshi Torigoe, Tadao Nakashima, Izumi Akazaki
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Publication number: 20030085253Abstract: It is an object of the present invention to provide spherical metal particles having excellent monodispersity. The present invention relates to a method of manufacturing monodisperse spherical metal particles characterized by passing liquid metal through a porous membrane so as to disperse the resulting liquid metal particles in a continuous liquid phase.Type: ApplicationFiled: October 15, 2002Publication date: May 8, 2003Applicant: MIYAZAKI PREFECTUREInventors: Masataka Shimizu, Kiyoshi Torigoe, Tadao Nakashima, Izumi Akazaki
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Patent number: 4657875Abstract: Porous glass product of the invention comprises about 60 to about 80% by weight of SiO.sub.2, about 7 to about 15% by weight of Al.sub.2 O.sub.3, about 6 to about 12% by weight of B.sub.2 O.sub.3, about 3 to about 7% by weight of Na.sub.2 O and about 3 to 7% by weight of CaO and having pores about 200 to about 10000 nm in size and circular in cross section.Type: GrantFiled: July 22, 1985Date of Patent: April 14, 1987Assignee: Miyazaki PrefectureInventors: Tadao Nakashima, Masataka Shimizu, Mikio Kawano