Patents Assigned to modeRNA Therapeutics
  • IN VIVO PRODUCTION OF PROTEINS
    Publication number: 20150111248
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: March 15, 2013
    Publication date: April 23, 2015
    Applicant: Moderna Therapeutics, Inc.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Sayda M. Elbashir, Matthias John, Atanu Roy, Susan Whoriskey, Kristy M. Wood, Paul Hatala, Jason P. Schrum, Kenechi Ejebe, Jeff Lynn Ellsworth, Justin Guild
  • Modified polynucleotides for the production of biologics and proteins associated with human disease
    Patent number: 8999380
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Grant
    Filed: March 9, 2013
    Date of Patent: April 7, 2015
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Sayda M. Elbashir, Matthias John, Atanu Roy, Susan Whoriskey, Kristy M. Wood, Paul Hatala, Jason P. Schrum, Kenechi Ejebe, Jeff Lynn Ellsworth, Justin Guild
  • MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF CYTOPLASMIC AND CYTOSKELETAL PROTEINS
    Publication number: 20150086614
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: March 9, 2013
    Publication date: March 26, 2015
    Applicant: Moderna Therapeutics, Inc.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Sayda M. Elbashir, Matthias John, Atanu Roy, Susan Whoriskey, Kristy M. Wood, Paul Hatala, Jason P. Schrum, Kenechi Ejebe, Jeff Lynn Ellsworth, Justin Guild
  • Compositions and methods of altering cholesterol levels
    Patent number: 8980864
    Abstract: The present invention relates to compositions, methods and kits using polynucleotides, primary transcripts and mmRNA molecules.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: March 17, 2015
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Stephen G. Hoge, Antonin de Fougerolles, Jeff Lynn Ellsworth
  • MODIFIED POLYNUCLEOTIDES ENCODING UDP GLUCURONOSYLTRANSFERASE 1 FAMILY, POLYPEPTIDE A1
    Publication number: 20140275229
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: May 19, 2014
    Publication date: September 18, 2014
    Applicant: Moderna Therapeutics, Inc.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey
  • COMPOSITIONS AND METHODS OF ALTERING CHOLESTEROL LEVELS
    Publication number: 20140275227
    Abstract: The present invention relates to compositions, methods and kits using polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: December 20, 2013
    Publication date: September 18, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Stephen G. Hoge, Antonin de Fougerolles, Jeff Lynn Ellsworth
  • MODIFIED POLYNUCLEOTIDES ENCODING CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED PROTEIN 4
    Publication number: 20140255467
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: December 13, 2013
    Publication date: September 11, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey, Ron Weiss
  • MODIFIED POLYNUCLEOTIDES ENCODING PROGRAMMED CELL DEATH 1
    Publication number: 20140255468
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: December 13, 2013
    Publication date: September 11, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey, Ron Weiss
  • MODIFIED POLYNUCLEOTIDES FOR TREATING PROTEIN DEFICIENCY
    Publication number: 20140249208
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: February 3, 2014
    Publication date: September 4, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey
  • Engineered nucleic acids and methods of use thereof
    Patent number: 8822663
    Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent diseases, disorders or conditions, or to improve a subject's heath or wellbeing.
    Type: Grant
    Filed: August 5, 2011
    Date of Patent: September 2, 2014
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Jason P. Schrum, Stéphane Bancel, Noubar B. Afeyan
  • ENGINEERED NUCLEIC ACIDS AND METHODS OF USE THEREOF
    Publication number: 20140243399
    Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent diseases, disorders or conditions, or to improve a subject's heath or wellbeing.
    Type: Application
    Filed: May 6, 2014
    Publication date: August 28, 2014
    Applicant: Moderna Therapeutics, Inc.
    Inventors: Jason P. Schrum, Stephane Bancel, Noubar B. Afeyan
  • MODIFIED POLYNUCLEOTIDES FOR TREATING GALACTOSYLCERAMIDASE PROTEIN DEFICIENCY
    Publication number: 20140221465
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: February 3, 2014
    Publication date: August 7, 2014
    Applicant: Moderna Therapeutics, Inc.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey
  • SIGNAL-SENSOR POLYNUCLEOTIDES
    Publication number: 20140206852
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of signal-sensor polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: December 20, 2013
    Publication date: July 24, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Stephen G. Hoge, Antonin de Fougerolles, Tirtha Chakraborty
  • ENGINEERED NUCLEIC ACIDS AND METHODS OF USE THEREOF FOR NON-HUMAN VERTEBRATES
    Publication number: 20140206752
    Abstract: Provided are formulations, compositions, kits and methods for delivering biological moieties such as modified nucleic acids into cells to induce, reduce or modulate protein expression in non-human vertebrates.
    Type: Application
    Filed: May 16, 2012
    Publication date: July 24, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Noubar B. Afeyan, Gregory Sieczkiewicz, Stephane Bancel
  • MODIFIED POLYNUCLEOTIDES FOR TREATING ARYLSULFATASE A PROTEIN DEFICIENCY
    Publication number: 20140206755
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: February 3, 2014
    Publication date: July 24, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey
  • MODIFIED POLYNUCLEOTIDES FOR TREATING GALACTOSIDASE, ALPHA PROTEIN DEFICIENCY
    Publication number: 20140200263
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: February 3, 2014
    Publication date: July 17, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey
  • SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES
    Publication number: 20140200261
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of signal-sensor polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: September 30, 2013
    Publication date: July 17, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Stephen G. Hoge, Tirtha Chakraborty, Joshua P. Frederick, Matthias John, Antonin de Fougerolles
  • MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS ASSOCIATED WITH BLOOD AND LYMPHATIC DISORDERS
    Publication number: 20140200262
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: December 12, 2013
    Publication date: July 17, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey, Sayda M. Elbashir
  • MODIFIED POLYNUCLEOTIDES FOR TREATING CARBOXYPEPTIDASE N, POLYPEPTIDE 1 PROTEIN DEFICIENCY
    Publication number: 20140200264
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: February 3, 2014
    Publication date: July 17, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey
  • MODIFIED POLYNUCLEOTIDES ENCODING BASIC HELIX-LOOP-HELIX FAMILY, MEMBER E41
    Publication number: 20140199371
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: December 12, 2013
    Publication date: July 17, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey, Ron Weiss