Patents Assigned to Modpro AB
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Patent number: 9377466Abstract: A molecular tool for use in a method of providing a molecule that is capable of binding a target molecule based on a set of polypeptides. A polypeptide having a sequence selected from SEQ ID NOs 1-32. The polypeptide may be used in a method of screening for a ligand-polypeptide conjugate capable of binding a target molecule for the ligand. A ligand-polypeptide conjugate, useful e.g. in therapy.Type: GrantFiled: September 6, 2011Date of Patent: June 28, 2016Assignee: Modpro ABInventors: Lars Baltzer, Adam Slosarczyk, Jonas Bergquist, Anders Virtanen
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Publication number: 20130261013Abstract: A molecular tool for use in a method of providing a molecule that is capable of binding a target molecule based on a set of polypeptides. A polypeptide having a sequence selected from SEQ ID NOs 1-32. The polypeptide may be used in a method of screening for a ligand-polypeptide conjugate capable of binding a target molecule for the ligand. A ligand-polypeptide conjugate, useful e.g. in therapy.Type: ApplicationFiled: September 6, 2011Publication date: October 3, 2013Applicant: MODPRO ABInventors: Lars Baltzer, Adam Slosarczyk, Jonas Bergquist, Anders Virtanen
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Publication number: 20130183737Abstract: The invention is based on the surprising finding that proteins regulated by excessive EGFR signalling in the liver may be used as biomarkers in the diagnosis, prognosis and/or monitoring of treatment of diseases, including liver cell dysplasia or hepatocellular carcinoma (HCC), wherein the protein is selected from a first group consisting of Arginase type II, 4931406C07Rik (Ester hydrolase C11orf54 homolog), Akr1c12 protein, Alanyl-tRNA synthetase, Aldo-keto reductase family 1 member C14, Aldo-keto reductase family 1 member C6, Aldolase 3, Alpha glucosidase 2, Beta 5-tubulin, Cai protein (Pdia4), cDNA sequence BC021917 (dihydroxyacetone kinase 2 homolog), Farnesyl diphosphate synthetase, Fatty acid binding protein 5 epidermal, Inosine triphosphatase, Interleukin 25, Kininogen 1, LIM and SH3 protein 1, Major vault protein, Nucb1 protein, Poly(rC) binding protein 2; heterogeneous nuclear ribonucleoprotein X, Psmd11 protein, RIKEN cDNA 2410004H02, Rps12 protein, Sars1 protein, Sorcin, T43799 proteasome protein pType: ApplicationFiled: June 23, 2011Publication date: July 18, 2013Applicant: MODPRO ABInventor: Jurgen Borlak
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Patent number: 8436138Abstract: Isolated polypeptides comprising one or more of SEQ ID NOs 3-18, which show a specific binding for C-reactive protein (CRP). A library of isolated polypeptides comprising the polypeptides of SEQ ID NOs 3-18 is disclosed, as are compositions comprising such polypeptides.Type: GrantFiled: August 26, 2011Date of Patent: May 7, 2013Assignee: Modpro ABInventor: Lars Baltzer
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Publication number: 20120202218Abstract: A method for determining the presence of a compound in a liquid solution, by admixing the liquid solution with a plurality of nanoparticles; providing conditions effective to cause aggregation of the nanoparticles in the liquid solution in the absence of said compound in the liquid solution; and observing a detectable signal reflecting the amount of aggregation of nanoparticles in the liquid solution, wherein the presence of the compound in the liquid solution results in a detectable signal reflecting a reduced amount of aggregation of nanoparticles in the liquid solution, in comparison to the amount of aggregation of nanoparticles obtained in the liquid solution in the absence of the compound therein. A nanoparticle, a composition, a kit and a for multi-well plate for use in the method are also disclosed. In some embodiments the association is cation-, anion and/or PH induced e.g. by using helix-loop-helix polypeptides as first and second molecules attached to the nanoparticles.Type: ApplicationFiled: September 14, 2009Publication date: August 9, 2012Applicant: MODPRO ABInventors: Bo Liedberg, Daniel Aili, Lars Baltzer, Karin Enander, Johan Rydberg
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Publication number: 20120053124Abstract: A polypeptide dimer is provided wherein both protomers have a sequence according to SEQ ID NO: 1 and at least one phosphocholine derivative is attached to the polypeptide. The polypeptide shows a specific binding for C-reactive protein (CRP). The utilization of the polypeptide in assays for determining the concentration of CRP is described. The purification of CRP, and compositions comprising the CRP also are provided.Type: ApplicationFiled: August 26, 2011Publication date: March 1, 2012Applicant: MODPRO ABInventor: Lars BALTZER
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Patent number: 8017347Abstract: A polypeptide dimer is provided wherein both protomers have a sequence according to SEQ ID NO: 1 and at least one phosphocholine derivative is attached to the polypeptide. The polypeptide shows a specific binding for C-reactive protein (CRP). The utilization of the polypeptide in assays for determining the concentration of CRP is described. The purification of CRP, and compositions comprising the CRP also are provided.Type: GrantFiled: April 10, 2007Date of Patent: September 13, 2011Assignee: Modpro ABInventor: Lars Baltzer
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Publication number: 20100099575Abstract: Novel peptide having a sequence according to SEQ. ID. No. 1, SEQ. ID. No. 2 and/or SEQ. ID. No. 3 are disclosed and also polypeptide scaffold consisting of a four helix bundle formed of two dimerized helix-loop-helix motifs, said helix-loop-helix motifs having sequences according to SEQ. ID. No. 1, SEQ. ID. No. 2 and/or SEQ. ID. No. 3 which may comprise a fluorescent probe at the side chain of Lys15 and a ligand with affinity for a target molecule at the side chain of Lys8 or Lys34. Also disclosed are polypeptide scaffolds for use in biosensing applications with or without the polypeptide scaffold anchored to a solid surface.Type: ApplicationFiled: July 31, 2009Publication date: April 22, 2010Applicant: MODPRO ABInventors: Lars Baltzer, Gunnar Dolphin, Bo Liedberg, Ingemar Lundstrom
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Publication number: 20090305298Abstract: A polypeptide dimer is provided wherein both protomers have a sequence according to SEQ ID NO: 1 and at least one phosphocholine derivative is attached to the polypeptide. The polypeptide shows a specific binding for C-reactive protein (CRP). The utilization of the polypeptide in assays for determining the concentration of CRP is described. The purification of CRP, and compositions comprising the CRP also are provided.Type: ApplicationFiled: April 10, 2007Publication date: December 10, 2009Applicant: MODPRO ABInventor: Lars Baltzer
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Patent number: 7569661Abstract: Novel peptide having a sequence according to SEQ. ID. No. 1, SEQ. ID. No. 2 and/or SEQ. ID. No. 3 are disclosed and also polypeptide scaffold consisting of a four helix bundle formed of two dimerized helix-loop-helix motifs, said helix-loop-helix motifs having sequences according to SEQ. ID. No. 1, SEQ. ID. No. 2 and/or SEQ. ID. No. 3 which may comprise a fluorescent probe at the side chain of Lys15 and a ligand with affinity for a target molecule at the side chain of Lys8 or Lys34. Also disclosed are polypeptide scaffolds for use in biosensing applications with or without the polypeptide scaffold anchored to a solid surface.Type: GrantFiled: March 26, 2003Date of Patent: August 4, 2009Assignee: Modpro ABInventors: Lars Baltzer, Gunnar Dolphin, Bo Liedberg, Ingemar Lundström
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Publication number: 20090182119Abstract: A catalytically active peptide comprising an imidazole function in position i flanked by at least one functional group to be amidated in position i+3+4k, where k is an integer equal to or higher than ?1 or in position i?4?4n, wherein n is an integer equal to or higher than 0, characterized in that it also comprises at least one activating group in position i+4+4n or i?3?4n, respectively, wherein n is as above.Type: ApplicationFiled: January 16, 2008Publication date: July 16, 2009Applicant: MODPRO ABInventor: Lars BALTZER
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Patent number: 7514222Abstract: Disclosed are novel polypeptides of a four helix bundle formed of two dimerized helix-loop-helix motifs, wherein either both have a sequence according to SEQ. ID No. 1, SEQ. ID No. 2, SEQ. ID No. 3, SEQ. ID No. 4, SEQ. ID No. 5, or SEQ. ID No. 7, or one has a sequence according to SEQ. ID No. 6, and the other one has a sequence according to SEQ. ID No. 1, SEQ. ID No. 2, SEQ. ID No. 3, SEQ. ID No. 4, SEQ. ID No. 5 or SEQ. ID No. 7.Type: GrantFiled: November 18, 2002Date of Patent: April 7, 2009Assignee: Modpro ABInventor: Lars Baltzer
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Publication number: 20080177032Abstract: A catalytically active peptide comprising an imidazole function in position i flanked by at least one functional group to be amidated in position i+3+4k, where k is an integer equal to or higher than ?1 or in position i?4?4n, wherein n is an integer equal to or higher than 0, characterized in that it also comprises at least one activating group in position i+4+4n or i?3?4n, respectively, wherein n is as above.Type: ApplicationFiled: January 16, 2008Publication date: July 24, 2008Applicant: MODPRO ABInventor: Lars BALTZER
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Patent number: 7364889Abstract: A catalytically active peptide comprising an imidazole function in position i flanked by at least one functional group to be amidated in position i+3+4k, where k is an integer equal to or higher than ?1 or in position i?4?4n, wherein n is an integer equal to or higher than 0, characterized in that it also comprises at least one activating group in position i+4+4n or i?3?4n, respectively, wherein n is as above.Type: GrantFiled: April 4, 2006Date of Patent: April 29, 2008Assignee: Modpro ABInventor: Lars Baltzer
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Patent number: 7230072Abstract: A method for site-selective acyl transfer in amidation of folded polypeptides and proteins based on the use of a chemical structure element comprising an imidazole function, such as histidine, in position i flanked by at least one functional group to be amidated, such as lysinc, in position i+3+4k. where K is an integer equal to or higher than ?1, or in position i?4?4n, wherein n is an integer equal to or higher than 0, and at least one activating group, such as serine, in position i+4+4n or i?3?4n, respectively.Type: GrantFiled: May 7, 2001Date of Patent: June 12, 2007Assignee: Modpro ABInventor: Lars Baltzer
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Publication number: 20060165712Abstract: A catalytically active peptide comprising an imidazole function in position i flanked by at least one functional group to be amidated in position i+3+4k, where k is an integer equal to or higher than ?1 or in position i?4?4n, wherein n is an integer equal to or higher than 0, characterized in that it also comprises at least one activating group in position i+4+4n or i?3?4n, respectively, wherein n is as above.Type: ApplicationFiled: April 4, 2006Publication date: July 27, 2006Applicant: MODPRO ABInventor: Lars Baltzer