Patents Assigned to Modular Genetics, Inc.
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Patent number: 11371066Abstract: Methods, compositions, and cells for generating acyl alcohols. Compositions comprising acyl alcohols. Methods of cleaving acyl amino acids and/or acyl alcohols to generate free fatty acids, free amino acids, and/or free alcohols.Type: GrantFiled: July 13, 2016Date of Patent: June 28, 2022Assignee: Modular Genetics, Inc.Inventor: Kevin A. Jarrell
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Patent number: 11155843Abstract: In certain embodiments, the present invention comprises compositions and methods useful in the generation of acyl amino acids. In certain embodiments, the present invention provides an engineered polypeptide comprising a peptide synthetase domain; in some such embodiments, the engineered polypeptide comprises only a single peptide synthetase domain. In some embodiments, the present invention provides an engineered peptide synthetase that is substantially free of a thioesterase domain, and/or a reductase domain. In certain embodiments, the present invention provides an acyl amino acid composition comprising a plurality of different forms of an acyl amino acid. In some such compositions, substantially all of the acyl amino acids within the composition contain the same amino acid moiety and differ with respect to acyl moiety. We also described populations where the fatty acid si for example 95% one length (C14, myristic).Type: GrantFiled: March 18, 2020Date of Patent: October 26, 2021Assignee: Modular Genetics, Inc.Inventors: Kevin A. Jarrell, Gabriel O. Reznik, Prashanth Vishwanath, Michelle Pynn
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Patent number: 10640799Abstract: In certain embodiments, the present invention comprises compositions and methods useful in the generation of acyl amino acids. In certain embodiments, the present invention provides an engineered polypeptide comprising a peptide synthetase domain; in some such embodiments, the engineered polypeptide comprises only a single peptide synthetase domain. In some embodiments, the present invention provides an engineered peptide synthetase that is substantially free of a thioesterase domain, and/or a reductase domain. In certain embodiments, the present invention provides an acyl amino acid composition comprising a plurality of different forms of an acyl amino acid. In some such compositions, substantially all of the acyl amino acids within the composition contain the same amino acid moiety and differ with respect to acyl moiety. We also described populations where the fatty acid si for example 95% one length (C14, myristic).Type: GrantFiled: May 14, 2018Date of Patent: May 5, 2020Assignee: Modular Genetics, Inc.Inventors: Kevin A. Jarrell, Gabriel O. Reznik, Prashanth Vishwanath, Michelle Pynn
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Publication number: 20190062759Abstract: Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides. In certain embodiments, an acyl amino acid produced using compositions and/or methods of the present invention comprises cocoyl glutamate.Type: ApplicationFiled: August 31, 2018Publication date: February 28, 2019Applicant: Modular Genetics, Inc.Inventors: Kevin A. Jarrell, Prashanth Vishwanath, Gabriel Oscar Reznik
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Patent number: 10093935Abstract: Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides. In certain embodiments, an acyl amino acid produced using compositions and/or methods of the present invention comprises cocoyl glutamate.Type: GrantFiled: September 30, 2016Date of Patent: October 9, 2018Assignee: Modular Genetics, Inc.Inventors: Kevin A. Jarrell, Prashanth Vishwanath, Gabriel Oscar Reznik
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Patent number: 9970036Abstract: Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides.Type: GrantFiled: March 14, 2014Date of Patent: May 15, 2018Assignee: MODULAR GENETICS, INC.Inventors: Kevin A. Jarrell, Gabriel O. Reznik, Prashanth Vishwanath, Michelle Pynn
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Patent number: 9493800Abstract: Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides. In certain embodiments, an acyl amino acid produced using compositions and/or methods of the present invention comprises cocoyl glutamate.Type: GrantFiled: July 19, 2011Date of Patent: November 15, 2016Assignee: MODULAR GENETICS, INC.Inventors: Kevin A. Jarrell, Prashanth Vishwanath, Gabriel Reznik
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Patent number: 8129119Abstract: The present invention provides an improved system for linking nucleic acids to one another. In particular, the present invention provides techniques for producing DNA product molecules that may be easily and directly ligated to recipient molecules. The product molecules need not be cleaved with restriction enzymes in order to undergo such ligation. In preferred embodiments of the invention, the DNA product molecules are produced through iterative DNA synthesis reactions, so that the product molecules are amplified products. The invention further provides methods for directed ligation of product molecules (i.e., for selective ligation of certain molecules within a collection of molecules), and also for methods of exon shuffling, in which multiple different product molecules are produced in a single ligation reaction. Preferred embodiments of the invention involve ligation of product molecules encoding functional protein domains, particularly domains naturally found in conserved gene families.Type: GrantFiled: May 4, 2006Date of Patent: March 6, 2012Assignee: Modular Genetics, Inc.Inventors: Kevin Jarrell, Brian Turczyk
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Patent number: 7981685Abstract: Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides. In certain embodiments, an acyl amino acid produced using compositions and/or methods of the present invention comprises cocoyl glutamate.Type: GrantFiled: April 16, 2008Date of Patent: July 19, 2011Assignee: Modular Genetics, Inc.Inventors: Kevin A. Jarrell, Prashanth Vishwanath, Gabriel Reznik
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Publication number: 20110059487Abstract: The present invention provides, among other things, engineered microorganisms and methods that allow efficient conversion of soy carbohydrates to industrial chemicals by fermentation. In some embodiments, the invention provides microbial cells engineered to have increased efficiency in utilizing a soy carbon source (e.g., soy molasses, soy meal, and/or soy hulls) as compared to a parent cell. In some embodiments, microbial cells are engineered to have altered (e.g., increased) expression or activity of one or more carbohydrate modifying enzymes (e.g., glycosidases). In some embodiments, microbial cells are engineered to have altered localization of carbohydrate modifying enzymes (e.g., glycosidases). In some embodiments, engineered microbial cells provided herein are used to produce industrial chemicals (e.g., surfactin) using soy components as primary or sole carbon sources.Type: ApplicationFiled: June 24, 2010Publication date: March 10, 2011Applicant: Modular Genetics, Inc.Inventors: Kevin A. Jarrell, Gabriel Reznik, Michelle A. Pynn
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Publication number: 20110034557Abstract: Antimicrobial compositions and methods of using the compositions are described herein. The compositions include an antibacterial acyl amino acid. In some embodiments, the acyl amino acid is a fatty acylated glutamate. The methods herein include methods of using acyl amino acids for treating and preventing bacterial infections.Type: ApplicationFiled: February 19, 2010Publication date: February 10, 2011Applicant: MODULAR GENETICS, INC.Inventors: Kevin A. Jarrell, Gabriel Reznik
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Publication number: 20090298130Abstract: The present invention provides novel methods of generating a nucleic acid molecule. In certain embodiments, a double stranded nucleic acid chunk is generated from a ladder complex comprising partially complementary oligonucleotides, which chunk is combined with a nucleic acid acceptor molecule. In certain embodiments, the assembled chunk/nucleic acid acceptor molecule complex may be propagated in vivo or in vitro. The present invention also provides improved systems for generating a plurality of nucleic acid molecules that differ at one or more nucleotide positions. In certain embodiments, the plurality of nucleic acid molecules encodes a polypeptide or portion of a polypeptide.Type: ApplicationFiled: January 30, 2009Publication date: December 3, 2009Applicant: Modular Genetics, Inc.Inventors: Kevin Jarrell, Jonah Keegan, Nathan Tichovolsky, Bob Rogers
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Publication number: 20090269832Abstract: The present invention provides novel methods of growing of microorganisms in cell culture media comprising crude glycerol as a carbon source. The present invention further provides novel cell culture media comprising crude glycerol as a carbon source. In certain embodiments, inventive cell culture media substantially lack refined glycerol. In certain embodiments, inventive cell culture media comprise crude glycerol as the sole carbon source.Type: ApplicationFiled: November 4, 2008Publication date: October 29, 2009Applicant: Modular Genetics, Inc.Inventors: Kevin A. Jarrell, Gabriel Reznik
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Publication number: 20090143242Abstract: The present invention provides sequences and reagents for preparing microarrays with internal controls. Specifically, the present invention defines and provides sequences that are not present in the hybridizing mRNA or cDNA, and therefore can be used both as hybridization controls and for inter-spot normalization.Type: ApplicationFiled: July 7, 2008Publication date: June 4, 2009Applicants: MODULAR GENETICS, INC., TRUSTEES OF BOSTON UNIVERSITYInventors: Sean Quinlan, Temple Smith, Prashanth Vishwanath
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Patent number: 7485423Abstract: The present invention provides novel methods of generating a nucleic acid molecule. In certain embodiments, a double stranded nucleic acid chunk is generated from a ladder complex comprising partially complementary oligonucleotides, which chunk is combined with a nucleic acid acceptor molecule. In certain embodiments, the assembled chunk/nucleic acid acceptor molecule complex may be propagated in vivo or in vitro. The present invention also provides improved systems for generating a plurality of nucleic acid molecules that differ at one or more nucleotide positions. In certain embodiments, the plurality of nucleic acid molecules encodes a polypeptide or portion of a polypeptide.Type: GrantFiled: November 11, 2005Date of Patent: February 3, 2009Assignee: Modular Genetics, Inc.Inventors: Kevin Jarrell, Jonah Keegan, Nathan Tichovolsky, Bob Rogers
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Patent number: 7435562Abstract: The present invention provides improved techniques and reagents for producing nucleic acid molecules. In certain preferred embodiments, the nucleic acid molecules are modular vectors. In certain preferred embodiments, the nucleic acid molecules are produced in polymerase chain reactions employing terminator primer residues.Type: GrantFiled: March 5, 2003Date of Patent: October 14, 2008Assignees: Modular Genetics, Inc., The Trustees of Boston UniversityInventors: Kevin A. Jarrell, William F. Donahue, Brian M. Turczyk
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Patent number: 7396646Abstract: The present invention provides sequences and reagents for preparing microarrays with internal controls. Specifically, the present invention defines and provides sequences that are not present in the hybridizing mRNA or cDNA, and therefore can be used both as hybridization controls and for inter-spot normalization.Type: GrantFiled: September 12, 2005Date of Patent: July 8, 2008Assignees: Modular Genetics, Inc., Trustees of Boston UniversityInventors: Sean Quinlan, Temple Smith, Prashanth Vishwanath