Abstract: The present invention concerns cyclic compounds, compositions comprising the cyclic compounds, linkers, a method of preparing a carrying agent:cyclic compound adduct, a method for treating disorders such as proliferation disorders (e.g., malignancies), bone deficiency diseases, and autoimmune diseases, and a method for suppressing the growth of, or inducing apoptosis in, cells (e.g., malignant cells).
Type:
Grant
Filed:
September 26, 2014
Date of Patent:
July 3, 2018
Assignees:
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC., UNIVERSITY OF SOUTH FLORIDA, MODULATION THERAPEUTICS, THE SCRIPPS RESEARCH INSTITUTE
Inventors:
Lori Hazlehurst, Christoph Rader, Xiuling Li, Mark McLaughlin