Patents Assigned to Moehs Ibérica, S.L.
  • Method for the synthesis of 2,4-dimethylpyrimidin-5-ol, intermediates, and method for the synthesis of Lemborexant using the intermediates
    Patent number: 11891375
    Abstract: A method is for the synthesis of 2,4-dimethylpyrimidin-5-ol, which can be used as an intermediate compound in the synthesis of Lemborexant. The method includes reacting a nitrophenyl compound with N,N-dimethylformamide diethyl acetal.
    Type: Grant
    Filed: July 25, 2022
    Date of Patent: February 6, 2024
    Assignee: MOEHS IBERICA, S.L.
    Inventors: Abdeslam Akhatou, Alicia Dobarro Rodríguez
  • 3-((R)-2-(amino-2-phenylethyl)-1-(2-fluoro-6 trifluoromethyl benzyl)-5-iodo-6-methyl-1H-pyrimidine-2,4-dione or a salt thereof, process for its preparation, and its use in the synthesis of elagolix
    Patent number: 11858901
    Abstract: A new intermediate is useful in the synthesis of elagolix. A process for obtaining the intermediate includes reacting a precursor with iodine monochloride in the presence of an organic solvent. A process for preparing elagolix makes use of the intermediate. The intermediate can be 3-((R)-2-(amino-2-phenylethyl)-1-(2-fluoro-6-trifluoromethylbenzyl)-5-iodo-6-methyl-1H-pyrimidine-2,4-dione or a salt thereof, such as a hydrochloride.
    Type: Grant
    Filed: March 10, 2020
    Date of Patent: January 2, 2024
    Assignee: MOEHS IBERICA, S.L.
    Inventors: Roberto Ballette, Oscar Jiménez Alonso, Elena García García, Alicia Dobarro Rodríguez
  • Method for preparing 3-[(3S)-7-bromo-2-oxo-5-(pyridin-2-yl)-2,3-dihydro-1H-[1,4]-benzodiazepin-3-yl] propionic acid methyl ester, and compounds useful in that method
    Patent number: 11236064
    Abstract: The present disclosure relates to a method for preparing 3-[(3S)-7-bromo-2-oxo-5-(pyridin-2-yl)-2,3-dihydro-1H-[1,4]-benzodiazepin-3-yl] propionic acid methyl ester from (2-amino-5-bromo-phenyl)-pyridin-2-yl-methanone. Also disclosed are compounds useful as intermediates in the method, methyl (4S)-4-amino-5-[4-bromo-2-(pyridin-2-carbonyl)anilino]-5-oxo-pentanoate hydrobromide salt and methyl (4S)-4-(benzyloxycarbonylamino)-5-[4-bromo-2-(pyridin-2-carbonyl)anilino]-5-oxo-pentanoate.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: February 1, 2022
    Assignee: MOEHS IBERICA S.L.
    Inventors: Carles Sánchez Casals, Alicia Dobarro Rodríguez
  • Crystalline form of sitagliptin sulfate
    Patent number: 9181260
    Abstract: A novel crystalline form of sitagliptin sulfate is provided. In addition, a method for obtaining the crystalline form, pharmaceutical compositions comprising the novel crystalline form and the crystalline form for use as a medicament are provided.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: November 10, 2015
    Assignee: MOEHS IBERICA, S.L.
    Inventors: Maria del Carmen Bernabeu Martínez, Alicia Dobarro Rodríguez, Cristobal Galán Rodríguez
  • Process for preparing a leukotriene antagonist and an intermediate thereof
    Patent number: 8163924
    Abstract: Dicyclohexylamine salt of formula (IIa) or a pharmaceutically acceptable solvate thereof, including a hydrate, and its process for preparation are provided. The invention also relates to processes for the preparation of montelukast of formula (I) or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, including a hydrate, based on the conversion of a salt of formula (IIa) into its form of free acid, followed by reaction with a compound of formula (III) CH3MgX, wherein X is halogen, in a suitable solvent, optionally in the presence of a Lewis acid.
    Type: Grant
    Filed: July 30, 2008
    Date of Patent: April 24, 2012
    Assignee: Moehs Ibérica, S.L.
    Inventors: Carles Sánchez Casals, Helena Camps Ramírez De Cartagena