Abstract: A non-naturally occurring chimeric polypeptide having an activity provided by a TGF-beta family member is disclosed. The chimeric polypeptide of an embodiment comprises two or more domains or fragments from parental TGF-beta proteins operably linked such that the resulting polypeptide is capable of modulating a pathway associated with a TGF-beta family member. In one embodiment, the pathway is a SMAD or DAXX pathway.
Type:
Grant
Filed:
May 31, 2017
Date of Patent:
November 29, 2022
Assignees:
MOGAM INSTITUTE FOR BIOMEDICAK RESEARCH, JOINT CENTER FOR BIOSCIENCES
Inventors:
Sen Yon Choe, Chi Hoon Ahn, Ho Cheol Kim, Hyeon Jin Kim