Patents Assigned to MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH
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Publication number: 20230192851Abstract: An anti-CD3 antibody and a pharmaceutical composition, and their uses are disclosed. The anti-CD3 antibody are useful for treating or preventing cancer. The antibody has high affinity and specificity for CD3 and thus can be effectively used in cancer prevention or treatment.Type: ApplicationFiled: October 3, 2022Publication date: June 22, 2023Applicants: Green Cross Corporation, Mogam Institute For Biomedical ResearchInventors: Ki Su KIM, Jun Hong Jeong, Ae Rin Yoon, Eun Jung Song, Hye Ji Choi, Ok Jae Lim, Yun Jung Lee, Hyung Kwon Lim, Jong Wha Won
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Patent number: 11642408Abstract: An antigen variant and a use thereof are disclosed. The antigen variant is a protein, among surface proteins (gE) of the varicella zoster virus, exhibits a high expression level and high immunogenicity, and thus, when the antigen variant is used as a vaccine composition, the vaccine composition has more excellent safety compared to a live virus vaccine, and the antigen variant exhibits a higher expression level in a host cell compared to other antigens. The antigen variant is useful as a vaccine for preventing or treating chicken pox or herpes zoster caused by the varicella zoster virus.Type: GrantFiled: May 22, 2019Date of Patent: May 9, 2023Assignee: MOGAM INSTITUTE FOR BIOMEDICAL RESEARCHInventors: Hyo Jung Nam, Ga Young Ji, Eunmi Kim
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Patent number: 11498965Abstract: The present invention relates to an anti-CD3 antibody and a pharmaceutical composition for cancer treatment comprising same. The antibody according to the present invention has high affinity and specificity for CD3 and thus can be effectively used in cancer prevention or treatment.Type: GrantFiled: October 22, 2018Date of Patent: November 15, 2022Assignees: GREEN CROSS CORPORATION, MOGAM INSTITUTE FOR BIOMEDICAL RESEARCHInventors: Ki Su Kim, Jun Hong Jeong, Ae Rin Yoon, Eun Jung Song, Hye Ji Choi, Ok Jae Lim, Yun Jung Lee, Hyung Kwon Lim, Jong Wha Won
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Patent number: 11447559Abstract: Provided according to an embodiment of the present invention is an antibody that binds specifically to B-cell maturation antigen (BCMA) and comprises a heavy chain variable domain (VH domain) composed of a sequence having a homology of 80% or higher with any one of the amino acid sequences of SEQ ID NOS: 1 to 20, or a fragment thereof.Type: GrantFiled: September 21, 2018Date of Patent: September 20, 2022Assignees: MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH, GREEN CROSS CORPORATION, DANA-FARBER CANCER INSTITUTE, INC.Inventors: Hye-Ji Choi, Jae-Chan Park, Hyung-Kwon Lim
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Publication number: 20220289819Abstract: A steric epitope of CEACAM1 is disclosed. An anti-CEACAM1 antibody or a fragment thereof, which specifically binds to CEACAM1 is disclosed. A steric epitope of CEACAM1 includes all amino acids in critical positions for specific binding to an anti-CEACAM1 antibody and maintains an appropriate three-dimensional structure, and thus can high affinity for an anti-CEACAM1 antibody. In addition, an antibody, or a fragment thereof, that specifically binds to a steric epitope can effectively suppress CEACAM1-CEACAM1 interaction and CEACAM1-CEACAM6 interaction.Type: ApplicationFiled: November 7, 2019Publication date: September 15, 2022Applicants: GREEN CROSS CORPORATION, MOGAM INSTITUTE FOR BIOMEDICAL RESEARCHInventors: Mi-Young OH, Jae-Chul LEE, Hye Young PARK, Hye In YUM, Dong-Sik KIM
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Publication number: 20220251176Abstract: A fusion protein including a fragment of an anti-mesothelin antibody, an anti-CD3 antibody or an anti-EGFR antibody; a bispecific antibody that is specific to mesothelin and CD3; a trispecific antibody that is specific to mesothelin, CD3 and EGFR are provided. The fusion protein is effective in treating cancer. The bispecific or trispecific antibody can be prepared in a high yield and with high purity, and has excellent tumor killing and growth inhibitory effects, and thus can be effectively used in cancer treatment.Type: ApplicationFiled: December 16, 2019Publication date: August 11, 2022Applicants: GREEN CROSS CORPORATION, MOGAM INSTITUTE FOR BIOMEDICAL RESEARCHInventors: Yangmi LIM, Shinai LEE, Jonghwa WON, Yong-Yea PARK, Aerin YOON, Sua LEE, Okjae LIM, Sojung LIM, Munkyung KIM
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Patent number: 11401343Abstract: The present invention relates to an anti-MSLN antibody and a pharmaceutical composition for cancer treatment comprising same. The anti-MSLN antibody according to the present invention has high affinity and specificity for MSLN and thus can be effectively used in cancer prevention or treatment.Type: GrantFiled: October 22, 2018Date of Patent: August 2, 2022Assignees: GREEN CROSS CORPORATION, MOGAM INSTITUTE FOR BIOMEDICAL RESEARCHInventors: Ki Su Kim, Jung Hong Jeong, Dong Sik Kim, Yang Mi Lim, Yong Yea Park, Hyung Kwon Lim, Jong Wha Won
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Patent number: 11332528Abstract: The present invention provides anti-CEACAM1 antibodies with improved binding abilities specific to CEACAM1, and a use thereof. Anti-CEACAM1 antibodies according to the present invention exhibit superior binding abilities specific to CEACAM1, and also activate the anti-cancer immune functions of cytotoxic T cells and natural killer cells, and thus, each one of them can be effectively used as an anti-cancer agent and a composition for treating cancer.Type: GrantFiled: March 23, 2018Date of Patent: May 17, 2022Assignees: MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH, GREEN CROSS CORPORATIONInventors: So-Young Eun, Miyoung Oh, Hye-Young Park, Mijung Lee, Aerin Yoon, Hye In Yum, Hyemi Nam, Eunhee Lee, Jongwha Won
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Patent number: 11198733Abstract: The present invention provides a pharmaceutical composition for inhibiting the metastasis of cancer, comprising, as an active ingredient, an antibody that specifically binds to an epidermal growth factor receptor, and a method for inhibiting the metastasis of cancer using the composition. The composition or the method is effective in inhibiting the invasion of various gastric cancer cell lines induced by EGFR ligands. Therefore, the pharmaceutical composition can be usefully used for inhibiting the metastasis of cancer.Type: GrantFiled: April 27, 2016Date of Patent: December 14, 2021Assignees: GREEN CROSS CORPORATION, MOGAM INSTITUTE FOR BIOMEDICAL RESEARCHInventors: Jong-hwa Won, Yangmi Lim, Min-Kyu Hur
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Publication number: 20210324094Abstract: An asymmetric fusion protein in which a fragment of an antibody binding to an insulin receptor, an iduronate-2-sulfatase (IDS) enzyme, and an Fc region are fused, and a use thereof are disclosed. The fusion protein can cross the blood-brain barrier (BBB) to deliver the IDS enzyme to the brain. Therefore, a pharmaceutical composition containing the fusion protein as an active ingredient can be used as a therapeutic agent for a central nervous system disease and particularly, is expected to prevent and treat various diseases caused by ribosome accumulation.Type: ApplicationFiled: October 18, 2019Publication date: October 21, 2021Applicant: MOGAM INSTITUTE FOR BIOMEDICAL RESEARCHInventors: Ki Joon CHO, Mijung LEE, Eun Jung SONG, Ki Su KIM, Kwan Yub KANG, Eui Cheol CHO
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Patent number: 11046749Abstract: A chimera protein according to the present application has a significantly increased in vivo half-life when administered because of a vWF domain coupled to FVIII, such that when used as a hemophilia A therapeutic agent, convenience for patients can be increased and medical expenses can be reduced.Type: GrantFiled: June 23, 2017Date of Patent: June 29, 2021Assignee: MOGAM INSTITUTE FOR BIOMEDICAL RESEARCHInventors: Injae Oh, Seung-Hoon Lee, Eui-Cheol Jo, Mee Sook Oh, Jae Hwan Ryu, Yong Jae Kim, So Ra Kim, Jin-hyun Park
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Publication number: 20210187099Abstract: An antigen variant and a use thereof are disclosed. The antigen variant is a protein, among surface proteins (gE) of the varicella zoster virus, exhibits a high expression level and high immunogenicity, and thus, when the antigen variant is used as a vaccine composition, the vaccine composition has more excellent safety compared to a live virus vaccine, and the antigen variant exhibits a higher expression level in a host cell compared to other antigens. The antigen variant is useful as a vaccine for preventing or treating chicken pox or herpes zoster caused by the varicella zoster virus.Type: ApplicationFiled: May 22, 2019Publication date: June 24, 2021Applicant: MOGAM INSTITUTE FOR BIOMEDICAL RESEARCHInventors: Hyo Jung NAM, Ga Young JI, Eunmi KIM
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Publication number: 20210079062Abstract: An in-vivo release-sustained recombinant coagulation factor VIII and a method for making it are disclosed. The recombinant coagulation factor VIII has a biocompatible polymer that is conjugated to at least one sugar chain terminus. The in-vivo release-sustained recombinant coagulation factor VIII has a protein surface modified through a method more elaborate and safer than conventional glycoconjugation techniques and enjoys the advantage of decreasing in immunogenicity and increasing in in-vivo sustainability.Type: ApplicationFiled: January 11, 2019Publication date: March 18, 2021Applicant: MOGAM INSTITUTE FOR BIOMEDICAL RESEARCHInventors: Kwan Yub KANG, Taeyoon KIM, Jae Hwan RYU, Yeon Jung KIM, Yong Jae KIM
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Patent number: 10940198Abstract: The present invention relates to a herpes zoster vaccine composition, which comprises glycoprotein E of Varicella zoster virus, a glucopyranosyl lipid adjuvant, and a metabolic oil, and selectively increases a cell-mediated immune reaction without having disadvantages of attenuated live vaccines, thereby exhibit high safety and a high preventive effect against herpes zoster.Type: GrantFiled: December 20, 2017Date of Patent: March 9, 2021Assignees: MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH, INFECTIOUS DISEASE RESEARCH INSTITUTEInventors: Hyo Jung Nam, Eun Mi Kim, Duck Hyang Shin, Steven G. Reed, Kang Il Yoo, Sung Jun Hong
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Publication number: 20200407713Abstract: The present invention relates to a transformed human cell and a use thereof and, more particularly, to a cell transformed with a gene for coding an MHC I cell membrane receptor and an MHC II cell membrane receptor by using a gene expression suppressing system using a guide RNA, and a use thereof. Such a transformed cell can effectively exhibit the therapeutic effect of cells even in vivo, and cannot be removed by an in vivo immune response. Therefore, it is expected that a composition comprising the immunocyte as an active ingredient can be usefully used for the treatment of cancer, infectious diseases, degenerative diseases or immunological diseases.Type: ApplicationFiled: November 16, 2018Publication date: December 31, 2020Applicant: MOGAM INSTITUTE FOR BIOMEDICAL RESEARCHInventors: Ok Jae LIM, Mun Kyung KIM, Yun Jung LEE, Jee Won LEE, Woo Seok YANG, Yu Young KIM, Yongin Eun KWON, Seung Hyon CHOE
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Patent number: 10874734Abstract: The present invention relates to a vaccine composition for prevention or treatment of chicken pox or herpes zoster, the vaccine composition comprising a surface protein (gE) of Varicella Zoster Virus and especially an aluminum salt as an adjuvant. The vaccine composition according to the present invention employs a protein antigen, thus showing greater outstanding stability than a live vaccine and has an optimized mixture ratio of adjuvants to elicit effective antibody induction, thereby being useful as a vaccine for preventing or treating Varicella Zoster Virus-caused chicken pox or herpes zoster.Type: GrantFiled: November 24, 2017Date of Patent: December 29, 2020Assignee: MOGAM INSTITUTE FOR BIOMEDICAL RESEARCHInventors: Hyo Jung Nam, Eunmi Kim, Gayoung Ji
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Patent number: 10851175Abstract: The present invention relates to an antibody specifically bound to mesothelin (MSLN), a nucleic acid encoding the antibody, a vector and a host cell including the nucleic acid, a method for producing the antibody, and a pharmaceutical composition for treating cancer or tumor including the antibody as an active ingredient. The antibody specifically bound to the mesothelin according to the present invention has high affinity and specificity to an antigen, such that it is possible to develop an antibody effectively usable for treatment or diagnosis of cancer or tumor diseases.Type: GrantFiled: September 23, 2016Date of Patent: December 1, 2020Assignees: MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH, GREEN CROSS CORPORATIONInventors: Dong-Sik Kim, Eun Jung Song, Mijung Lee, Eun-Hee Lee, Miyoung Oh, Jae Chan Park, Kisu Kim, Sujeong Kim, Hyung-Kwon Lim, Kyuhyun Lee, Jongwha Won, Soongyu Choi, Young Seoub Park
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Publication number: 20200325216Abstract: A non-naturally occurring chimeric polypeptide having an activity provided by a TGF-beta family member is disclosed. The chimeric polypeptide of an embodiment comprises two or more domains or fragments from parental TGF-beta proteins operably linked such that the resulting polypeptide is capable of modulating a pathway associated with a TGF-beta family member. In one embodiment, the pathway is a SMAD or DAXX pathway.Type: ApplicationFiled: May 31, 2017Publication date: October 15, 2020Applicants: MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH, JOINT CENTER FOR BIOSCIENCEInventors: Sen Yon CHOE, Chi Hoon AHN, Ho Cheoi KIM, Hyeon Jin KIM
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Publication number: 20200317779Abstract: The present invention relates to an anti-CD3 antibody and a pharmaceutical composition for cancer treatment comprising same. The antibody according to the present invention has high affinity and specificity for CD3 and thus can be effectively used in cancer prevention or treatment.Type: ApplicationFiled: October 22, 2018Publication date: October 8, 2020Applicants: GREEN CROSS CORPORATIO, MOGAM INSTITUTE FOR BIOMEDICAL RESEARCHInventors: Ki Su KIM, Jun Hong JEONG, Ae Rin YOON, Eun Jung SONG, Hye Ji CHOI, Ok Jae LIM, Yun Jung LEE, Hyung Kwon LIM, Jong Wha WON
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Publication number: 20200299395Abstract: Provided according to an embodiment of the present invention is an antibody that binds specifically to B-cell maturation antigen (BCMA) and comprises a heavy chain variable domain (VH domain) composed of a sequence having a homology of 80% or higher with any one of the amino acid sequences of SEQ ID NOS: 1 to 20, or a fragment thereof.Type: ApplicationFiled: September 21, 2018Publication date: September 24, 2020Applicants: MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH, GREEN CROSS CORPORATIONInventors: Hye-Ji CHOI, Jae-Chan PARK, Hyung-Kwon LIM