Abstract: A patient respiratory and cardiovascular monitoring and evaluation system broadly comprising a wearable respiratory and cardiovascular monitoring garment, a number of sensors and microphones, and a patient computing device. The sensors may be positioned on various locations of the wearable garment for sensing heat rate, blood pressure, and thoracic impedance, among other vital health information. The microphones may similarly be positioned on various locations of the wearable garment for sensing lung and heart auscultations. The wearable garment may be worn close to the patient's chest wall for improving sensor and microphone data while retaining patient mobility. The patient computing device runs a monitoring application thereon and includes a graphical user interface having a number of virtual inputs for allowing the patient to initiate self-monitoring sessions and manage the signals and computer data received from the sensors and microphones.