Patents Assigned to Molecular Diagnostics, Inc.
  • Homogeneous analyte detection
    Patent number: 8338579
    Abstract: The present invention provides novel binding pair compositions of defined and limited stability comprising nucleic acid detection markers useful for the homogeneous, sensitive detection of analytes. Also provided are methods for the sensitive homogeneous detection of analytes, particularly analytes of clinical relevance. Kits for preparing binding pairs of the invention and for performing the methods of the invention are also provided.
    Type: Grant
    Filed: November 3, 2005
    Date of Patent: December 25, 2012
    Assignee: Iris Molecular Diagnostics, Inc.
    Inventors: Thomas Adams, Edward Jablonski
  • Polynucleotides for use as tags and tag complements, manufacture and use thereof
    Patent number: 7960537
    Abstract: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24mers is described.
    Type: Grant
    Filed: July 18, 2007
    Date of Patent: June 14, 2011
    Assignee: Luminex Molecular Diagnostics, Inc.
    Inventors: Petr Pancoska, Vit Janota, Albert S. Benight, Richard S. Bullock, Peter V. Riccelli, Daniel Kobler, Daniel Fieldhouse
  • Polynucleotides for use as tags and tag complements, manufacture and use thereof
    Patent number: 7943322
    Abstract: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24 mers is described.
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: May 17, 2011
    Assignee: Luminex Molecular Diagnostics, Inc.
    Inventors: Petr Pancoska, Vit Janota, Albert S. Benight, Richard S. Bullock, Peter V. Riccelli, Daniel Kobler, Daniel Fieldhouse
  • Polynucleotides for use as tags and tag complements, manufacture and use thereof
    Patent number: 7927809
    Abstract: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24mers is described.
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: April 19, 2011
    Assignee: Luminex Molecular Diagnostics, Inc.
    Inventors: Petr Pancoska, Vit Janota, Albert S. Benight, Richard S. Bullock, Peter V. Riccelli, Daniel Kobler, Daniel Fieldhouse
  • Polynucleotides for use as tags and tag complements, manufacture and use thereof
    Patent number: 7927808
    Abstract: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24mers is described.
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: April 19, 2011
    Assignee: Luminex Molecular Diagnostics, Inc.
    Inventors: Petr Pancoska, Vit Janota, Albert S. Benight, Richard S. Bullock, Peter V. Riccelli, Daniel Kobler, Daniel Fieldhouse
  • Polynucleotides for use as tags and tag complements, manufacture and use thereof
    Patent number: 7914997
    Abstract: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24mers is described.
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: March 29, 2011
    Assignee: Luminex Molecular Diagnostics, Inc.
    Inventors: Petr Pancoska, Vit Janota, Albert S. Benight, Richard S. Bullock, Peter V. Riccelli, Daniel Kobler, Daniel Fieldhouse
  • Capture moieties for nucleic acids and uses thereof
    Patent number: 7914989
    Abstract: A unimolecular probe for hybridization to a molecule comprising a target nucleic acid sequence, the probe includes: a first nucleic acid sequence complementary to the target sequence (target-binding sequence); and a second nucleic acid sequence complementary to a portion of the first nucleic acid sequence and capable of hybridization therewith to form a first intramolecular duplex. In use, the target and target-bind sequence hybridize to form a duplex. A probe can be used to detect a molecule containing the target sequence, act as a primer for synthesis or amplification, etc.
    Type: Grant
    Filed: May 25, 2007
    Date of Patent: March 29, 2011
    Assignee: Luminex Molecular Diagnostics, Inc.
    Inventors: Susan Bortolin, Roman L. Zastawny
  • Method of detecting mutations associated with thrombosis
    Patent number: 7879543
    Abstract: The present invention provides a method for the simultaneous identification of two or more single base changes in a plurality of target nucleotide sequences that are markers associated with cardiovascular diseases such as deep vein thrombosis and the like. Multiplex detection is accomplished using multiplexed tagged allele specific primer extension (ASPE) and hybridization of such extended primers to a probe, preferably an addressable anti-tagged support.
    Type: Grant
    Filed: November 17, 2004
    Date of Patent: February 1, 2011
    Assignee: Luminex Molecular Diagnostics, Inc.
    Inventors: Susan Bortolin, Frank Merante, Daniel Kobler, Daniel Fieldhouse, Margot Boszko, Hemanshu Modi, Richard A. Janeczko, Roman Zastawny
  • Polynucleotides for use as tags and tag complements, manufacture and use thereof
    Patent number: 7846734
    Abstract: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24 mers is described.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: December 7, 2010
    Assignee: Luminex Molecular Diagnostics, Inc.
    Inventors: Petr Pancoska, Vit Janota, Albert S. Benight, Richard S. Bullock, Peter V. Riccelli, Daniel Kobler, Daniel Fieldhouse
  • Polynucleotides for use as tags and tag complements, manufacture and use thereof
    Patent number: 7846668
    Abstract: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24 mers is described.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: December 7, 2010
    Assignee: Luminex Molecular Diagnostics, Inc.
    Inventors: Petr Pancoska, Vit Janota, Albert S. Benight, Richard S. Bullock, Peter V. Riccelli, Daniel Kobler, Daniel Fieldhouse
  • Polynucleotides for use as tags and tag complements, manufacture and use thereof
    Patent number: 7846669
    Abstract: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24mers is described.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: December 7, 2010
    Assignee: Luminex Molecular Diagnostics, Inc.
    Inventors: Petr Pancoska, Vit Janota, Albert S. Benight, Richard S. Bullock, Peter V. Riccelli, Daniel Kobler, Daniel Fieldhouse
  • Polynucleotides for use as tags and tag complements, manufacture and use thereof
    Patent number: 7846670
    Abstract: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24mers is described.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: December 7, 2010
    Assignee: Luminex Molecular Diagnostics, Inc.
    Inventors: Petr Pancoska, Vit Janota, Albert S. Benight, Richard S. Bullock, Peter V. Riccelli, Daniel Kobler, Daniel Fieldhouse
  • METHODS FOR SANGER SEQUENCING USING PARTICLE ASSOCIATED CLONAL AMPLICONS AND HIGHLY PARALLEL ELECTROPHORETIC SIZE-BASED SEPARATION
    Publication number: 20100112588
    Abstract: Methods for highly parallel Sanger sequencing are discussed. In particular, provided herein are methods using particles to clonally amplify templates and to introduce the amplified nucleic acids into many parallel channels with a single template per channel. Once in the channels, the nucleic acids are separated by size using electrophoresis to produce long read length sequencing information. Methods involving optical detection of the size-separated nucleic acids and analysis of the resulting electropherograms to yield the sequences are disclosed.
    Type: Application
    Filed: November 3, 2009
    Publication date: May 6, 2010
    Applicant: CAERUS MOLECULAR DIAGNOSTICS, INC.
    Inventors: Javier Farinas, Andrea Chow, John Wallace Parce
  • Families of non-cross-hybridizing polynucleotides for use as tags and tag complements, manufacture and use thereof
    Patent number: 7645868
    Abstract: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 1168 24mers is described.
    Type: Grant
    Filed: January 25, 2002
    Date of Patent: January 12, 2010
    Assignee: Luminex Molecular Diagnostics, Inc.
    Inventors: Daniel Kobler, Daniel Fieldhouse
  • Polynucleotides for use tags and tag complements, manufacture and use thereof
    Patent number: 7608398
    Abstract: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24mers is described.
    Type: Grant
    Filed: March 28, 2007
    Date of Patent: October 27, 2009
    Assignee: Luminex Molecular Diagnostics, Inc.
    Inventors: Petr Pancoska, Vit Janota, Albert S. Benight, Richard S. Bullock, Peter V. Riccelli, Daniel Kobler, Daniel Fieldhouse
  • MICROBUBBLES FOR AFFINITY SEPARATION
    Publication number: 20090176201
    Abstract: The present invention relates to methods, compositions and kits for affinity isolation, affinity purification and affinity assay based on microbubbles coated with an affinity molecule. Particularly, the invention provides protein microbubbles coated with an affinity molecule. In addition, the invention provides glass microbubbles coated with an affinity molecule. Methods of using the microbubbles of the invention for isolating analytes and cells are specifically provided.
    Type: Application
    Filed: November 3, 2005
    Publication date: July 9, 2009
    Applicant: Iris Molecular Diagnostics, Inc
    Inventors: Edward Jablonski, Thomas Adams
  • Homogeneous Analyte Detection
    Publication number: 20080131883
    Abstract: The present invention provides novel binding pair compositions of defined and limited stability comprising nucleic acid detection markers useful for the homogeneous, sensitive detection of analytes. Also provided are methods for the sensitive homogeneous detection of analytes, particularly analytes of clinical relevance. Kits for preparing binding pairs of the invention and for performing the methods of the invention are also provided.
    Type: Application
    Filed: November 3, 2005
    Publication date: June 5, 2008
    Applicant: Iris Molecular Diagnostics, Inc.
    Inventors: Thomas Adams, Edward Jablonski
  • Methods and compositions for modulating “marginally indiscriminant” hybridizations
    Patent number: 7244570
    Abstract: The invention relates to the field of molecular biology, nucleic acid chemistry and medical diagnostics. More specifically, it relates to methods and compositions for promoting the hybridization of a nucleic acid probe with a target nucleic acid sequence which is not perfectly matched to the probe.
    Type: Grant
    Filed: July 30, 2004
    Date of Patent: July 17, 2007
    Assignee: Luminex Molecular Diagnostics, Inc.
    Inventors: Michael J. Lane, Albert S. Benight, Brian D. Faldasz
  • Capture moieties for nucleic acids and uses thereof
    Patent number: 7230092
    Abstract: A unimolecular probe for hybridization to a molecule comprising a target nucleic acid sequence, the probe includes: a first nucleic acid sequence complementary to the target sequence (target-binding sequence); a second nucleic acid sequence complementary to a portion of the first nucleic acid sequence and capable of hybridization therewith to form a first intramolecular duplex. In use, the target and target-binding sequence hybridize to form a duplex. A probe can be used to detect a molecule containing the target sequence, act as a primer for synthesis or amplification, etc.
    Type: Grant
    Filed: June 6, 2001
    Date of Patent: June 12, 2007
    Assignee: Luminex Molecular Diagnostics, Inc.
    Inventors: Susan Bortolin, Roman L. Zastawny
  • Polynucleotides for use as tags and tag complements, manufacture and use thereof
    Patent number: 7226737
    Abstract: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24mers is described.
    Type: Grant
    Filed: January 25, 2002
    Date of Patent: June 5, 2007
    Assignee: Luminex Molecular Diagnostics, Inc.
    Inventors: Petr Pancoska, Vit Janota, Albert S. Benight, Richard S. Bullock, Peter V. Riccelli, Daniel Kobler, Daniel Fieldhouse