Abstract: The invention concerns genes involved in the molecular paths for tumor suppression and/or resistance to viruses, and whereof the cell expression is in particular induced or inhibited during apoptosis and/or tumor suppression.
Abstract: Mice that are deficient in p53 are found to have memory disorders and/or behavioral disorders such as increased anxiety. A method of using p53-deficient mice to screen compounds for memory restoring activity and/or anti-anxiety activity is described.
Type:
Grant
Filed:
July 26, 1999
Date of Patent:
July 26, 2005
Assignee:
Molecular Engines Laboratories
Inventors:
Robert Amson, Jean-Michel Lassalle, Adam Telerman
Abstract: A compound that inhibits the cellular expression of a nucleotide sequence corresponding to all or part of the presenilin 1 gene, the compound comprising an antisense molecule comprising the antisense of a polynucleotide sequence selected from the group consisting of the entire polynucleotide sequence of the presenilin 1 gene, a fragment of the sequence of the presenilin 1 gene, the promoter or other regulatory sequence of the presenilin 1 gene and a polynucleotide sequence that is at least 90% homologous to the polynucleotide sequence of the presenilin 1 gene is described. Pharmaceuticals containing and methods of inhibiting the presenilin 1 gene using such compound are also described. A compound and method of inhibiting the expression product of the presenilin 1 gene also is described. A method of treating a patient having a condition characterized by excessive cell growth also is described. A method of diagnosing cancer also is described.
Abstract: The present invention relates to the use of a compound inhibiting the expression of the TPT1 gene, or of the products which it controls, for producing a drug which is intended for treating cancer.
Type:
Application
Filed:
November 27, 2002
Publication date:
May 8, 2003
Applicant:
Molecular Engines Laboratories
Inventors:
Adam Telerman, Robert Amson, Marius Tuijnder
Abstract: Tumor Suppressor Activated Pathway (TSAP) genes and nucleotide sequences therefore as well as vectors and cells containing such nucleotide sequences and various uses therefore are described. The mechanism by which TSAP 3 activates apoptosis also is described. Pharmaceutical compositions and methods for preventing tumorigenesis also is described.
Type:
Grant
Filed:
April 6, 2000
Date of Patent:
January 7, 2003
Assignee:
Société Molecular Engines Laboratories a French
Société anonyme
Inventors:
Adam Telerman, Robert Amson, Daniel Cohen