Abstract: Microfluidic radiopharmaceutical production system and process for synthesizing per run approximately, but not less than, ten (10) unit doses of radiopharmaceutical biomarker for use in positron emission tomography (PET). A radioisotope from an accelerator or other radioisotope generator is introduced into a reaction vessel, along with organic and aqueous reagents, and the mixture heated to synthesize a solution of a pre-selected radiopharmaceutical. The solution is purified by passing through a combination of solid phase extraction purification components, trap and release components, and a filter. The synthesis process reduces waste and allows for production of biomarker radiopharmaceuticals on site and close to the location where the unit dose will be administered to the patient.

Abstract: A target assembly to produce radioisotopes for the synthesis of radiopharmaceuticals. The target assembly includes a target vessel with a target chamber adapted to receive a target material. A thin cover sheet of particle-permeable material covers the target chamber. In a bombardment process, a high-energy particle beam generated by a cyclotron or particle accelerator strikes the thin cover sheet, whereby at least some of the particles from the particle beam penetrate to the target chamber so as to interact with the target material, altering the nuclear makeup of some of the atoms in the target material to produce radioisotopes.

Abstract: A self-referencing radiation detector to test the radiochemical purity of a sample radiopharmaceutical solution. In some embodiments, the self-referencing radiation detector measures the radioactivity of a sample radiopharmaceutical solution before the sample radiopharmaceutical solution is passed through a high performance liquid chromatography column. The radiation detector then measures the radioactivity of each separated molecularly distinct species from the high performance liquid chromatography column. The radiochemical purity of the sample radiopharmaceutical solution is calculated by comparing the measured radioactivity of separated molecularly distinct species from said high performance liquid chromatography column to the measured radioactivity of the sample radiopharmaceutical solution before the sample radiopharmaceutical solution is passed through the high performance liquid chromatography column.

Abstract: A target assembly to produce radioisotopes for the synthesis of radiopharmaceuticals. The target assembly includes a target vessel with a target chamber adapted to receive a target material. A thin cover sheet of particle-permeable material covers the target chamber. In a bombardment process, a high-energy particle beam generated by a cyclotron or particle accelerator strikes the thin cover sheet, whereby at least some of the particles from the particle beam penetrate to the target chamber so as to interact with the target material, altering the nuclear makeup of some of the atoms in the target material to produce radioisotopes.

Abstract: A microfluidic radiopharmaceutical production system and process for synthesizing per run approximately, but not less than, one (1) unit dose of a radiopharmaceutical biomarker for use in positron emission tomography (PET). The radiopharmaceutical production system includes a reaction vessel that receives a radioisotope from an accelerator or other radioisotope generator. Organic and aqueous reagents are introduced into the reaction vessel, and the mixture is heated to synthesize a solution of a pre-selected radiopharmaceutical. The radiopharmaceutical solution is purified by passing the solution through a solid phase extraction column and a filter. The synthesis process produces per run a quantity of radiopharmaceutical approximately equal to, but not less than, one (1) unit dose of a radiopharmaceutical, reducing waste and allowing for the production of radiopharmaceutical on an as-needed basis.

Abstract: An improved biomarker generator and a method suitable for efficiently producing short lived radiopharmaceuticals in quantities on the order of a unit dose. The improved biomarker generator includes a particle accelerator and a radiopharmaceutical micro-synthesis system. The micro-accelerator of the improved biomarker generator is optimized for producing radioisotopes useful in synthesizing radiopharmaceuticals in quantities on the order of one unit dose allowing for significant reductions in size, power requirements, and weight when compared to conventional radiopharmaceutical cyclotrons.

Abstract: A solid fiduciary marker for registering at least two images when imaging the same subject using distinct imaging devices is disclosed. The solid fiduciary marker is visible in at least two of a Positron Emission Tomography (PET), Single Photon Emission Computed Tomography (SPECT), Planar gamma camera, X-ray CT, planar X-ray, Magnetic Resonance Imaging (MRI), and optical imager. The marker includes at least two of various doping compounds to be detected by the various imaging systems. The doping compounds include a positron emitting nuclide, a gamma emitting nuclide, a doping compound, metal, and a silicone-based polymer is used in association with an MRI device.

Abstract: A method of diagnosing or monitoring a neurological condition in a subject is described. The method includes performing a first magnetic resonance method on a subject to produce a first data set, performing a second magnetic resonance method on the subject to produce a second data set, and analyzing the first data set and the second data set.

Abstract: An apparatus for image elastic scattering spectroscopy is disclosed that is comprised of a light source for generating polarized light. Means are provided to convey the polarized light to a target. A collector receives light reflected from the target. A detector is responsive to the collector for generating images at both parallel and perpendicular polarizations for each of a plurality of wavelengths. A range finder detects a distance to the target. Control electronics control the image generation and the range finder. The apparatus may be configured to image areas on the surface of the body or configured so as to be inserted into various body cavities. Typically, the apparatus will be used in conjunction with an analyzer for analyzing the images for evidence of abnormal cells. Methods of gathering data and of screening for abnormal cells are also disclosed.

Abstract: A closure (10) for shielding, and selectively providing access to, the targeting assembly of a particle accelerator of a radioisotope production system. The closure (10) includes at least one, and in one embodiment, first and second doors (44, 46), for selectively covering an opening in the housing of the particle accelerator which provides access to the targeting assembly. A door mounting assembly is also provided for mounting the first and second doors (44, 46) on the housing of the particle accelerator. In one embodiment the door mounting assembly includes a frame (30) for being secured about the opening in the particle accelerator accessing the targeting assembly. Further, in one embodiment the frame (30) and first and second doors (44, 46) are fabricated of copper.

Abstract: Apparatus and methods for automating a sequence of basic chemistry operations through a recipe. Software running on a workstation communicating with a controller allows an operator to operate the process controller, view the process, log the process, and maintain the recipe. The controller communicates with the process hardware and receives commands from the workstation, stores the commands, interprets the commands to perform the process, and provides monitoring information to the workstation. The workstation software uses a recipe to control the process. The recipe is expressed in terms of the process. The controller runs software routines for process control and for hardware control.

Abstract: A closure (10) for shielding, and selectively providing access to, the targeting assembly of a particle accelerator of a radioisotope production system. The closure (10) includes at least one, and in one embodiment, first and second doors (44, 46), for selectively covering an opening in the housing of the particle accelerator which provides access to the targeting assembly. A door mounting assembly is also provided for mounting the first and second doors (44, 46) on the housing of the particle accelerator. In one embodiment the door mounting assembly includes a frame (30) for being secured about the opening in the particle accelerator accessing the targeting assembly. Further, in one embodiment the frame (30) and first and second doors (44, 46) are fabricated of copper.