Abstract: The present application relates to hybridization chain reaction (HCR). In particular, compositions and methods are presented for ultrasensitive molecular detection using HCR signal amplification. Some embodiments and methods involve cooperative probe junctions, reporter-labeled probes, and nonlinear HCR signal amplification.
Type:
Grant
Filed:
April 15, 2024
Date of Patent:
April 22, 2025
Assignees:
California Institute of Technology, Molecular Instruments, Inc.
Inventors:
Harry M T Choi, Chun Hao R. Chen, Mike C. Liu, Aneesh Acharya, Niles A. Pierce