Patents Assigned to Molecular Loop Biosciences, Inc.
  • Methods and compositions for evaluating genetic markers
    Patent number: 11840730
    Abstract: Aspects of the invention relates to methods and compositions that are useful to reduce bias and increase the reproducibility of multiplex analysis of genetic loci. In some configurations, predetermined preparative steps and/or nucleic acid sequence analysis techniques are used in multiplex analyses for a plurality of genetic loci in a plurality of samples.
    Type: Grant
    Filed: November 19, 2020
    Date of Patent: December 12, 2023
    Assignee: MOLECULAR LOOP BIOSCIENCES, INC.
    Inventors: Gregory Porreca, Uri Laserson
  • Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
    Patent number: 11768200
    Abstract: The invention generally relates to methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction. In certain embodiments, methods of the invention involve obtaining a template nucleic acid, incorporating a pair of sequence identifiers into the template, and sequencing the template.
    Type: Grant
    Filed: June 4, 2021
    Date of Patent: September 26, 2023
    Assignee: Molecular Loop Biosciences, Inc.
    Inventors: Gregory Porreca, Mark Umbarger, George Church
  • Methods for selectively suppressing non-target sequences
    Patent number: 11408024
    Abstract: The invention generally relates to negative selection of nucleic acids. The invention provides methods and systems that remove unwanted segments of nucleic acid in a sample so that a target gene or region of interest may be analyzed without interference from the unwanted segments. A sample is obtained that includes single-stranded nucleic acid with one or more unwanted segments. Complementary nucleic acid is added to the single-stranded nucleic acid to create a double-stranded region that includes the unwanted segment. The double-stranded region is then digested, leaving single-stranded nucleic acid that includes the target gene or region of interest. This allows paralogs, pseudogenes, repetitive elements, and other segments of the genome that may be similar to the target gene or region of interest to be removed from the sample.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: August 9, 2022
    Assignee: Molecular Loop Biosciences, Inc.
    Inventors: Jeff Gole, Athurva Gore, Mark Umbarger
  • Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
    Patent number: 11041852
    Abstract: The invention generally relates to methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction. In certain embodiments, methods of the invention involve obtaining a template nucleic acid, incorporating a pair of sequence identifiers into the template, and sequencing the template.
    Type: Grant
    Filed: January 14, 2021
    Date of Patent: June 22, 2021
    Assignee: Molecular Loop Biosciences, Inc.
    Inventors: Gregory Porreca, Mark Umbarger, George Church
  • Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
    Patent number: 11041851
    Abstract: The invention generally relates to methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction. In certain embodiments, methods of the invention involve obtaining a template nucleic acid, incorporating a pair of sequence identifiers into the template, and sequencing the template.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: June 22, 2021
    Assignee: Molecular Loop Biosciences, Inc.
    Inventors: Gregory Porreca, Mark Umbarger, George Church