Patents Assigned to Molecular Medicine Research Institute
  • Methods of modulating apoptosis by administration of relaxin agonists or antagonists
    Patent number: 9534034
    Abstract: The present invention relates to the discovery that relaxin is associated with the development or maturation of body tissues. Knockouts of the gene encoding relaxin result in various abnormalities in the development of various tissues. The present invention provides methods of modulating apoptosis by administering a relaxin agonist or antagonist to a subject.
    Type: Grant
    Filed: February 17, 2012
    Date of Patent: January 3, 2017
    Assignee: Molecular Medicine Research Institute
    Inventors: Edward P. Amento, Chrishan S. Samuel
  • METHODS OF MODULATING APOPTOSIS BY ADMINISTRATION OF RELAXIN AGONISTS OR ANTAGONISTS
    Publication number: 20120238499
    Abstract: The present invention relates to the discovery that relaxin is associated with the development or maturation of body tissues. Knockouts of the gene encoding relaxin result in various abnormalities in the development of various tissues. The present invention provides methods of modulating apoptosis by administering a relaxin agonist or antagonist to a subject.
    Type: Application
    Filed: February 17, 2012
    Publication date: September 20, 2012
    Applicant: MOLECULAR MEDICINE RESEARCH INSTITUTE
    Inventors: Edward P. Amento, Chrishan S. Samuel
  • Methods of modulating apoptosis by administration of relaxin agonists or antagonists
    Patent number: 8119136
    Abstract: The present invention relates to the discovery that relaxin is associated with the development or maturation of body tissues. Knockouts of the gene encoding relaxin result in various abnormalities in the development of various tissues. The present invention provides methods of modulating apoptosis by administering a relaxin agonist or antagonist to a subject.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: February 21, 2012
    Assignee: Molecular Medicine Research Institute
    Inventors: Edward P. Amento, Christian S. Samuel
  • METHODS OF MODULATING APOPTOSIS BY ADMINISTRATION OF RELAXIN AGONISTS OR ANTAGONISTS
    Publication number: 20110059108
    Abstract: The present invention relates to the discovery that relaxin is associated with the development or maturation of body tissues. Knockouts of the gene encoding relaxin result in various abnormalities in the development of various tissues. The present invention provides methods of modulating apoptosis by administering a relaxin agonist or antagonist to a subject.
    Type: Application
    Filed: November 12, 2010
    Publication date: March 10, 2011
    Applicant: MOLECULAR MEDICINE RESEARCH INSTITUTE
    Inventors: Edward P. Amento, Chrishan S. Samuel
  • Methods of modulating apoptosis by administration of relaxin agonists or antagonists
    Patent number: 7833526
    Abstract: The present invention relates to the discovery that relaxin is associated with the development or maturation of body tissues. Knockouts of the gene encoding relaxin result in various abnormalities in the development of various tissues. The present invention provides methods of modulating apoptosis by administering a relaxin agonist or antagonist to a subject.
    Type: Grant
    Filed: July 23, 2007
    Date of Patent: November 16, 2010
    Assignee: Molecular Medicine Research Institute
    Inventors: Edward P. Amento, Chrishan S. Samuel
  • METHODS OF MODULATING APOPTOSIS BY ADMINISTRATION OF RELAXIN AGONISTS OR ANTAGONISTS
    Publication number: 20080085275
    Abstract: The present invention relates to the discovery that relaxin is associated with the development or maturation of body tissues. Knockouts of the gene encoding relaxin result in various abnormalities in the development of various tissues. The present invention provides methods of modulating apoptosis by administering a relaxin agonist or antagonist to a subject.
    Type: Application
    Filed: July 23, 2007
    Publication date: April 10, 2008
    Applicant: Molecular Medicine Research Institute
    Inventors: Edward Amento, Chrishan Samuel
  • Induction of apoptosis in cancer cells
    Patent number: RE42700
    Abstract: The present invention provides compounds that are inducers or inhibitors of apoptosis of apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical compositions and methods for treating mammals with leukemia or other forms of cancer or for treating disease conditions caused by apoptosis of cells.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: September 13, 2011
    Assignees: Sanford-Burnham Medical Research Institute, Oregon State University, SRI International, Molecular Medicine Research Institute, Department of Veterans Affairs, Wayne State University
    Inventors: Marcia Dawson, Joseph A. Fontana, Xiao-Kun Zhang, Mark Leid, Ling Jong, Peter D. Hobbs