Patents Assigned to Molecular Transfer, Inc.
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Patent number: 11866723Abstract: Disclosed herein are transfection complexes comprising at least one cell surface ligand; at least one helper lipid component; and a transfection enhancer. Also disclosed are pharmaceutical compositions comprising the disclosed transfection complexes, and a pharmaceutically acceptable carrier. Further, disclosed are methods of transfecting a cell, the method comprising the steps of: obtaining a transfection complex as disclosed; and contacting a cell with the transfection complex.Type: GrantFiled: January 20, 2020Date of Patent: January 9, 2024Assignee: MOLECULAR TRANSFER INC.Inventors: Gulilat Gebeyehu, Joel Jessee
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Patent number: 11085056Abstract: Disclosed herein are transfection complexes comprising at least one cell surface ligand; at least one helper lipid component; and a transfection enhancer. Also disclosed are pharmaceutical compositions comprising the disclosed transfection complexes, and a pharmaceutically acceptable carrier. Further, disclosed are methods of transfecting a cell, the method comprising the steps of: obtaining a transfection complex as disclosed; and contacting a cell with the transfection complex.Type: GrantFiled: August 26, 2016Date of Patent: August 10, 2021Assignee: MOLECULAR TRANSFER, INC.Inventors: Gulilat Gebeyehu, Joel Jessee
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Patent number: 10968240Abstract: New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.Type: GrantFiled: December 17, 2018Date of Patent: April 6, 2021Assignee: MOLECULAR TRANSFER, INC.Inventors: Gulilat Gebeyehu, Joel Jessee
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Patent number: 10883118Abstract: New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.Type: GrantFiled: November 21, 2018Date of Patent: January 5, 2021Assignee: Molecular Transfer Inc.Inventors: Joel Jessee, Gulilat Gebeyehu
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Patent number: 10538784Abstract: Disclosed herein are transfection complexes comprising at least one cell surface ligand; at least one helper lipid component; and a transfection enhancer. Also disclosed are pharmaceutical compositions comprising the disclosed transfection complexes, and a pharmaceutically acceptable carrier. Further, disclosed are methods of transfecting a cell, the method comprising the steps of: obtaining a transfection complex as disclosed; and contacting a cell with the transfection complex.Type: GrantFiled: March 1, 2017Date of Patent: January 21, 2020Assignee: MOLECULAR TRANSFER, INC.Inventors: Gulilat Gebeyehu, Joel Jessee
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Publication number: 20190352316Abstract: New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.Type: ApplicationFiled: December 17, 2018Publication date: November 21, 2019Applicant: MOLECULAR TRANSFER, INC.Inventors: Gulilat GEBEYEHU, Joel JESSEE
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Patent number: 10155780Abstract: New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes. The present invention is in the field of molecular biology, and more particularly in the field of transfection, which utilizes new compounds and methods for the introduction of nucleic acids into eukaryotic cells.Type: GrantFiled: October 28, 2013Date of Patent: December 18, 2018Assignee: MOLECULAR TRANSFER, INC.Inventors: Gulilat Gebeyehu, Joel Jessee
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Publication number: 20180340188Abstract: Disclosed herein are transfection complexes comprising at least one cell surface ligand; at least one helper lipid component; and a transfection enhancer. Also disclosed are pharmaceutical compositions comprising the disclosed transfection complexes, and a pharmaceutically acceptable carrier. Further, disclosed are methods of transfecting a cell, the method comprising the steps of: obtaining a transfection complex as disclosed; and contacting a cell with the transfection complex.Type: ApplicationFiled: August 26, 2016Publication date: November 29, 2018Applicant: MOLECULAR TRANSFER, INC.Inventors: Gulilat GEBEYEHU, Joel JESSE
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Patent number: 10138497Abstract: New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.Type: GrantFiled: September 18, 2017Date of Patent: November 27, 2018Assignee: Molecular Transfer, Inc.Inventors: Joel Jessee, Gulilat Gebeyehu
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Patent number: 9765359Abstract: New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.Type: GrantFiled: January 12, 2016Date of Patent: September 19, 2017Assignee: Molecular Transfer, Inc.Inventors: Joel Jessee, Gulilat Gebeyehu
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Publication number: 20170029448Abstract: New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes. The present invention is in the field of molecular biology, and more particularly in the field of transfection, which utilizes new compounds and methods for the introduction of nucleic acids into eukaryotic cells.Type: ApplicationFiled: October 28, 2013Publication date: February 2, 2017Applicant: MOLECULAR TRANSFER, INC.Inventors: Gulilat GEBEYEHU, Joel JESSEE
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Patent number: 9259475Abstract: New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.Type: GrantFiled: October 16, 2013Date of Patent: February 16, 2016Assignee: Molecular Transfer, Inc.Inventors: Joel Jessee, Gulilat Gebeyehu
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Publication number: 20140213637Abstract: New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.Type: ApplicationFiled: October 16, 2013Publication date: July 31, 2014Applicant: Molecular Transfer Inc.Inventors: Joel Jessee, Gulilat Gebeyehu
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Patent number: 8759499Abstract: Compositions and methods for improved delivery of macromolecules into eukaryotic cells are provided. Fusogenic peptides from fusion proteins of non-enveloped viruses enhance the efficiency of transfection of eukaryotic cells mediated by transfection agents such as cationic lipids, polycationic polymers such as PEI and dendrimers. These fusogenic peptides are used as part of a transfection complex that efficiently delivers a macromolecule, for example, a nucleic acid, into a eukaryotic cell. Novel cationic lipids and compositions of cationic lipids also are provided that may be used for the introduction of macromolecules such as nucleic acids, proteins and peptides into a variety of cells and tissues. The lipids can be used alone, in combination with other lipids and/or in combination with fusogenic peptides to prepare transfection complexes.Type: GrantFiled: March 28, 2011Date of Patent: June 24, 2014Assignee: Molecular Transfer, Inc.Inventors: Joel Jessee, Gulilat Gebeyehu
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Publication number: 20120156786Abstract: A ready-to-use electroporation cuvette is provided that includes a cuvette, first and second electrodes positioned within the cuvette and electroporation competent cells frozen in a suspension solution within the cuvette, wherein the electroporation cuvette is configured to permit electroporation of the cells when the cells are thawed. The electroporation cuvette may be sealed with a cap that may be color coded to aid the user.Type: ApplicationFiled: January 18, 2012Publication date: June 21, 2012Applicant: MOLECULAR TRANSFER, INC.Inventor: Robert L. Bebee
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Publication number: 20120052574Abstract: Compositions and methods for improved delivery of macromolecules into eukaryotic cells are provided. Fusogenic peptides from fusion proteins of non-enveloped viruses enhance the efficiency of transfection of eukaryotic cells mediated by transfection agents such as cationic lipids, polycationic polymers such as PEI and dendrimers. These fusogenic peptides are used as part of a transfection complex that efficiently delivers a macromolecule, for example, a nucleic acid, into a eukaryotic cell. Novel cationic lipids and compositions of cationic lipids also are provided that may be used for the introduction of macromolecules such as nucleic acids, proteins and peptides into a variety of cells and tissues. The lipids can be used alone, in combination with other lipids and/or in combination with fusogenic peptides to prepare transfection complexes.Type: ApplicationFiled: March 28, 2011Publication date: March 1, 2012Applicant: Molecular Transfer, Inc.Inventors: Joel Jessee, Gulilat Gebeyehu
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Patent number: 8105818Abstract: A ready-to-use electroporation cuvette is provided that includes a cuvette, first and second electrodes positioned within the cuvette and electroporation competent cells frozen in a suspension solution within the cuvette, wherein the electroporation cuvette is configured to permit electroporation of the cells when the cells are thawed. The electroporation cuvette may be sealed with a cap that may be color coded to aid the user.Type: GrantFiled: July 18, 2006Date of Patent: January 31, 2012Assignee: Molecular Transfer, Inc.Inventor: Robert L. Bebee
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Patent number: 8034977Abstract: Cationic lipid compositions are provided that are useful for efficient delivery of macromolecules, such as nucleic acids, into a wide variety of eukaryotic cell types. Methods for using the compositions also are provided.Type: GrantFiled: April 27, 2009Date of Patent: October 11, 2011Assignee: Molecular Transfer, Inc.Inventors: Gulilat Gebeyehu, Taysir M. Jaouni, Joel Jessee
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Publication number: 20110200624Abstract: Novel peptides derived from antibody complementarity determining regions (CDRs) that enhance delivery of macromolecules into cells, particularly when used in combination with cationic lipids, are provided. The peptides can be combined with cationic lipids, and compositions of cationic lipids associated with enhancer elements, to provide reagents that can complex with macromolecules such as nucleic acids, proteins and peptides and permit introduction of these macromolecules into a variety of cells and tissues in vitro or in vivo with greatly enhanced efficiency compared to other lipid-based reagents. Methods for delivering macromolecules into target cells and tissues using the lipids and enhancer elements are provided.Type: ApplicationFiled: July 31, 2009Publication date: August 18, 2011Applicant: MOLECULAR TRANSFER, INC.Inventor: Joel A. Jessee
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Patent number: 7915230Abstract: Compositions and methods for improved delivery of macromolecules into eukaryotic cells are provided. Fusogenic peptides from fusion proteins of non-enveloped viruses enhance the efficiency of transfection of eukaryotic cells mediated by transfection agents such as cationic lipids, polycationic polymers such as PEI and dendrimers. These fusogenic peptides are used as part of a transfection complex that efficiently delivers a macromolecule, for example, a nucleic acid, into a eukaryotic cell. Novel cationic lipids and compositions of cationic lipids also are provided that may be used for the introduction of macromolecules such as nucleic acids, proteins and peptides into a variety of cells and tissues. The lipids can be used alone, in combination with other lipids and/or in combination with fusogenic peptides to prepare transfection complexes.Type: GrantFiled: May 17, 2006Date of Patent: March 29, 2011Assignee: Molecular Transfer, Inc.Inventors: Joel Jessee, Gulilat Gebeyehu