Patents Assigned to Molecular Transfer, Inc.
  • Patent number: 11866723
    Abstract: Disclosed herein are transfection complexes comprising at least one cell surface ligand; at least one helper lipid component; and a transfection enhancer. Also disclosed are pharmaceutical compositions comprising the disclosed transfection complexes, and a pharmaceutically acceptable carrier. Further, disclosed are methods of transfecting a cell, the method comprising the steps of: obtaining a transfection complex as disclosed; and contacting a cell with the transfection complex.
    Type: Grant
    Filed: January 20, 2020
    Date of Patent: January 9, 2024
    Assignee: MOLECULAR TRANSFER INC.
    Inventors: Gulilat Gebeyehu, Joel Jessee
  • Patent number: 11085056
    Abstract: Disclosed herein are transfection complexes comprising at least one cell surface ligand; at least one helper lipid component; and a transfection enhancer. Also disclosed are pharmaceutical compositions comprising the disclosed transfection complexes, and a pharmaceutically acceptable carrier. Further, disclosed are methods of transfecting a cell, the method comprising the steps of: obtaining a transfection complex as disclosed; and contacting a cell with the transfection complex.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: August 10, 2021
    Assignee: MOLECULAR TRANSFER, INC.
    Inventors: Gulilat Gebeyehu, Joel Jessee
  • Patent number: 10968240
    Abstract: New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: April 6, 2021
    Assignee: MOLECULAR TRANSFER, INC.
    Inventors: Gulilat Gebeyehu, Joel Jessee
  • Patent number: 10883118
    Abstract: New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: January 5, 2021
    Assignee: Molecular Transfer Inc.
    Inventors: Joel Jessee, Gulilat Gebeyehu
  • Patent number: 10538784
    Abstract: Disclosed herein are transfection complexes comprising at least one cell surface ligand; at least one helper lipid component; and a transfection enhancer. Also disclosed are pharmaceutical compositions comprising the disclosed transfection complexes, and a pharmaceutically acceptable carrier. Further, disclosed are methods of transfecting a cell, the method comprising the steps of: obtaining a transfection complex as disclosed; and contacting a cell with the transfection complex.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: January 21, 2020
    Assignee: MOLECULAR TRANSFER, INC.
    Inventors: Gulilat Gebeyehu, Joel Jessee
  • Publication number: 20190352316
    Abstract: New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.
    Type: Application
    Filed: December 17, 2018
    Publication date: November 21, 2019
    Applicant: MOLECULAR TRANSFER, INC.
    Inventors: Gulilat GEBEYEHU, Joel JESSEE
  • Patent number: 10155780
    Abstract: New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes. The present invention is in the field of molecular biology, and more particularly in the field of transfection, which utilizes new compounds and methods for the introduction of nucleic acids into eukaryotic cells.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: December 18, 2018
    Assignee: MOLECULAR TRANSFER, INC.
    Inventors: Gulilat Gebeyehu, Joel Jessee
  • Publication number: 20180340188
    Abstract: Disclosed herein are transfection complexes comprising at least one cell surface ligand; at least one helper lipid component; and a transfection enhancer. Also disclosed are pharmaceutical compositions comprising the disclosed transfection complexes, and a pharmaceutically acceptable carrier. Further, disclosed are methods of transfecting a cell, the method comprising the steps of: obtaining a transfection complex as disclosed; and contacting a cell with the transfection complex.
    Type: Application
    Filed: August 26, 2016
    Publication date: November 29, 2018
    Applicant: MOLECULAR TRANSFER, INC.
    Inventors: Gulilat GEBEYEHU, Joel JESSE
  • Patent number: 10138497
    Abstract: New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: November 27, 2018
    Assignee: Molecular Transfer, Inc.
    Inventors: Joel Jessee, Gulilat Gebeyehu
  • Patent number: 9765359
    Abstract: New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: September 19, 2017
    Assignee: Molecular Transfer, Inc.
    Inventors: Joel Jessee, Gulilat Gebeyehu
  • Publication number: 20170029448
    Abstract: New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes. The present invention is in the field of molecular biology, and more particularly in the field of transfection, which utilizes new compounds and methods for the introduction of nucleic acids into eukaryotic cells.
    Type: Application
    Filed: October 28, 2013
    Publication date: February 2, 2017
    Applicant: MOLECULAR TRANSFER, INC.
    Inventors: Gulilat GEBEYEHU, Joel JESSEE
  • Patent number: 9259475
    Abstract: New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.
    Type: Grant
    Filed: October 16, 2013
    Date of Patent: February 16, 2016
    Assignee: Molecular Transfer, Inc.
    Inventors: Joel Jessee, Gulilat Gebeyehu
  • Publication number: 20140213637
    Abstract: New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.
    Type: Application
    Filed: October 16, 2013
    Publication date: July 31, 2014
    Applicant: Molecular Transfer Inc.
    Inventors: Joel Jessee, Gulilat Gebeyehu
  • Patent number: 8759499
    Abstract: Compositions and methods for improved delivery of macromolecules into eukaryotic cells are provided. Fusogenic peptides from fusion proteins of non-enveloped viruses enhance the efficiency of transfection of eukaryotic cells mediated by transfection agents such as cationic lipids, polycationic polymers such as PEI and dendrimers. These fusogenic peptides are used as part of a transfection complex that efficiently delivers a macromolecule, for example, a nucleic acid, into a eukaryotic cell. Novel cationic lipids and compositions of cationic lipids also are provided that may be used for the introduction of macromolecules such as nucleic acids, proteins and peptides into a variety of cells and tissues. The lipids can be used alone, in combination with other lipids and/or in combination with fusogenic peptides to prepare transfection complexes.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: June 24, 2014
    Assignee: Molecular Transfer, Inc.
    Inventors: Joel Jessee, Gulilat Gebeyehu
  • Publication number: 20120156786
    Abstract: A ready-to-use electroporation cuvette is provided that includes a cuvette, first and second electrodes positioned within the cuvette and electroporation competent cells frozen in a suspension solution within the cuvette, wherein the electroporation cuvette is configured to permit electroporation of the cells when the cells are thawed. The electroporation cuvette may be sealed with a cap that may be color coded to aid the user.
    Type: Application
    Filed: January 18, 2012
    Publication date: June 21, 2012
    Applicant: MOLECULAR TRANSFER, INC.
    Inventor: Robert L. Bebee
  • Publication number: 20120052574
    Abstract: Compositions and methods for improved delivery of macromolecules into eukaryotic cells are provided. Fusogenic peptides from fusion proteins of non-enveloped viruses enhance the efficiency of transfection of eukaryotic cells mediated by transfection agents such as cationic lipids, polycationic polymers such as PEI and dendrimers. These fusogenic peptides are used as part of a transfection complex that efficiently delivers a macromolecule, for example, a nucleic acid, into a eukaryotic cell. Novel cationic lipids and compositions of cationic lipids also are provided that may be used for the introduction of macromolecules such as nucleic acids, proteins and peptides into a variety of cells and tissues. The lipids can be used alone, in combination with other lipids and/or in combination with fusogenic peptides to prepare transfection complexes.
    Type: Application
    Filed: March 28, 2011
    Publication date: March 1, 2012
    Applicant: Molecular Transfer, Inc.
    Inventors: Joel Jessee, Gulilat Gebeyehu
  • Patent number: 8105818
    Abstract: A ready-to-use electroporation cuvette is provided that includes a cuvette, first and second electrodes positioned within the cuvette and electroporation competent cells frozen in a suspension solution within the cuvette, wherein the electroporation cuvette is configured to permit electroporation of the cells when the cells are thawed. The electroporation cuvette may be sealed with a cap that may be color coded to aid the user.
    Type: Grant
    Filed: July 18, 2006
    Date of Patent: January 31, 2012
    Assignee: Molecular Transfer, Inc.
    Inventor: Robert L. Bebee
  • Patent number: 8034977
    Abstract: Cationic lipid compositions are provided that are useful for efficient delivery of macromolecules, such as nucleic acids, into a wide variety of eukaryotic cell types. Methods for using the compositions also are provided.
    Type: Grant
    Filed: April 27, 2009
    Date of Patent: October 11, 2011
    Assignee: Molecular Transfer, Inc.
    Inventors: Gulilat Gebeyehu, Taysir M. Jaouni, Joel Jessee
  • Publication number: 20110200624
    Abstract: Novel peptides derived from antibody complementarity determining regions (CDRs) that enhance delivery of macromolecules into cells, particularly when used in combination with cationic lipids, are provided. The peptides can be combined with cationic lipids, and compositions of cationic lipids associated with enhancer elements, to provide reagents that can complex with macromolecules such as nucleic acids, proteins and peptides and permit introduction of these macromolecules into a variety of cells and tissues in vitro or in vivo with greatly enhanced efficiency compared to other lipid-based reagents. Methods for delivering macromolecules into target cells and tissues using the lipids and enhancer elements are provided.
    Type: Application
    Filed: July 31, 2009
    Publication date: August 18, 2011
    Applicant: MOLECULAR TRANSFER, INC.
    Inventor: Joel A. Jessee
  • Patent number: 7915230
    Abstract: Compositions and methods for improved delivery of macromolecules into eukaryotic cells are provided. Fusogenic peptides from fusion proteins of non-enveloped viruses enhance the efficiency of transfection of eukaryotic cells mediated by transfection agents such as cationic lipids, polycationic polymers such as PEI and dendrimers. These fusogenic peptides are used as part of a transfection complex that efficiently delivers a macromolecule, for example, a nucleic acid, into a eukaryotic cell. Novel cationic lipids and compositions of cationic lipids also are provided that may be used for the introduction of macromolecules such as nucleic acids, proteins and peptides into a variety of cells and tissues. The lipids can be used alone, in combination with other lipids and/or in combination with fusogenic peptides to prepare transfection complexes.
    Type: Grant
    Filed: May 17, 2006
    Date of Patent: March 29, 2011
    Assignee: Molecular Transfer, Inc.
    Inventors: Joel Jessee, Gulilat Gebeyehu