Patents Assigned to Molecumetics Ltd.
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Publication number: 20040029868Abstract: Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetics have utility in the treatment of cell adhesion-indicated diseases, such as multiple sclerosis, atherosclerosis, asthma and inflammatory bowel disease.Type: ApplicationFiled: February 7, 2003Publication date: February 12, 2004Applicant: Molecumetics, Ltd.Inventors: Michael Kahn, Masakatsu Eguchi, Hwa-Ok Kim, Marcin Stasiak
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Publication number: 20030236245Abstract: Compounds which mimic the secondary structure of helical regions of biologically active peptides and proteins having the following structure: 1Type: ApplicationFiled: August 29, 2002Publication date: December 25, 2003Applicant: Molecumetics, Ltd.Inventors: Vincent Huber, Jan Urban, Hiroshi Nakanishi, Masakatsu Eguchi, Jessymol Mathew, Min Sang Lee
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Publication number: 20030220328Abstract: Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins having the following structure are disclosed: 1Type: ApplicationFiled: October 9, 2002Publication date: November 27, 2003Applicant: Molecumetics Ltd.Inventors: Gangadhar Nagula, Jan Urban, Hwa-Ok Kim, Christopher Lum, Hiroshi Nakanishi
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Publication number: 20030166640Abstract: Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins having the following structure are disclosed: 1Type: ApplicationFiled: May 16, 2002Publication date: September 4, 2003Applicant: Molecumetics, Ltd.Inventors: Jan Urban, Hiroshi Nakanishi, Min S. Lee
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Publication number: 20030130168Abstract: Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins having the following structure are disclosed: 1Type: ApplicationFiled: June 12, 2002Publication date: July 10, 2003Applicant: Molecumetics, Ltd.Inventors: Marcin Stasiak, Michael Kahn
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Patent number: 6586426Abstract: There are disclosed &bgr;-sheet mimetics and methods relating to the same for imparting or stabilizing the &bgr;-sheet structure of a peptide, protein or molecule. In one aspect, the &bgr;-sheet mimetics are covalently attached at the end or within the length of the peptide or protein. The &bgr;-sheet mimetics have utility as protease inhibitors generally, including activity as serine protease inhibitors such as thrombin, elastase and Factor X.Type: GrantFiled: November 18, 1999Date of Patent: July 1, 2003Assignee: Molecumetics Ltd.Inventor: Michael Kahn
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Patent number: 6548500Abstract: Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetics have utility in the treatment of cell adhesion-indicated diseases, such as multiple sclerosis, atherosclerosis, asthma and inflammatory bowel disease.Type: GrantFiled: December 19, 2000Date of Patent: April 15, 2003Assignee: Molecumetics Ltd.Inventors: Michael Kahn, Masakatsu Eguchi, Hwa-Ok Kim, Marcin Stasiak
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Publication number: 20030027819Abstract: &bgr;-sheet mimetics and methods relating to the same are disclosed. The &bgr;-sheet mimetics have utility as protease and kinase inhibitors, as well as inhibitors of transcription factors and protein-protein binding interactions. Methods of the invention include administration of a &bgr;-sheet mimetic, or use of the same for the manufacture of a medicament for treatment of a variety of conditions associated with the targeted protease, kinase, transcription factor and/or protein-protein binding interaction.Type: ApplicationFiled: September 21, 2001Publication date: February 6, 2003Applicant: Molecumetics Ltd.Inventors: Maher N. Qabar, Michael K. McMillan, Michael S. Kahn, John E. Tulinsky, Cyprian O. Ogbu, Jessymol Mathew
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Patent number: 6440955Abstract: Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins having the following structure are disclosed: wherein A, R1, R2, R2a, R3, R3a and R4 are as defined herein. Such compounds have utility over a wide range of fields, including use as diagnostic and therapeutic agents. In particular, compounds of this invention are useful in pharmaceutical compositions as anti-inflammatory agents. Libraries containing the compounds of this invention are also disclosed, as well as methods for screening the same to identify biologically active members.Type: GrantFiled: September 4, 2001Date of Patent: August 27, 2002Assignee: Molecumetics Ltd.Inventors: Marcin Stasiak, Michael Kahn
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Patent number: 6413963Abstract: Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetics have utility in the treatment of cell adhesion-indicated diseases, such as multiple sclerosis, atherosclerosis, asthma and inflammatory bowel disease.Type: GrantFiled: December 19, 2000Date of Patent: July 2, 2002Assignee: Molecumetics, Ltd.Inventors: Michael Kahn, Masakatsu Eguchi, Hwa-Ok Kim, Marcin Stasiak
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Publication number: 20020065416Abstract: Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins having the following structure are disclosed: 1Type: ApplicationFiled: September 4, 2001Publication date: May 30, 2002Applicant: Molecumetics ltd.Inventors: Marcin Stasiak, Michael Kahn
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Patent number: 6372744Abstract: &bgr;-sheet mimetics and methods relating to the same are disclosed. The &bgr;-sheet mimetics have utility as protease and kinase inhibitors, as well as inhibitors of transcription factors and protein-protein binding interactions. Methods of the invention include administration of a &bgr;-sheet mimetic, or use of the same for the manufacture of a medicament for treatment of a variety of conditions associated with the targeted protease, kinase, transcription factor and/or protein-protein binding interaction.Type: GrantFiled: February 9, 2000Date of Patent: April 16, 2002Assignee: Molecumetics Ltd.Inventors: Maher N. Qabar, Michael K. McMillan, Michael S. Kahn, John E. Tulinsky, Cyprian O. Ogbu, Jessymol Mathew
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Patent number: 6294525Abstract: Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins having the following structure are disclosed: wherein A, R1, R2, R2a, R3, R3a and R4 are as defined herein. Such compounds have utility over a wide range of fields, including use as diagnostic and therapeutic agents. In particular, compounds of this invention are useful in pharmaceutical compositions as anti-inflammatory agents. Libraries containing the compounds of this invention are also disclosed, as well as methods for screening the same to identify biologically active members.Type: GrantFiled: September 1, 1999Date of Patent: September 25, 2001Assignee: Molecumetics Ltd.Inventors: Marcin Stasiak, Michael Kahn
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Patent number: 6245764Abstract: There are disclosed &bgr;-sheet mimetics and methods relating to the same for imparting or stabilizing the &bgr;-sheet structure of a peptide, protein or molecule. In one aspect, &bgr;-sheet mimetics are disclosed having utility as protease inhibitors in general and, more specifically, as serine protease inhibitors such as thrombin, elastase and Factor X inhibitors. In one embodiment, the &bgr;-sheet mimetic is a thrombin inhibitor.Type: GrantFiled: January 20, 1998Date of Patent: June 12, 2001Assignee: Molecumetics Ltd.Inventors: Michael Kahn, Cyprian O. Ogbu, Masakatsu Eguchi, Hwa-Ok Kim, Patrick Douglas Boatman, Jr.
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Patent number: 6184223Abstract: Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetics have utility in the treatment of cell adhesion-indicated diseases, such as multiple sclerosis, atherosclerosis, asthma and inflammatory bowel disease.Type: GrantFiled: June 25, 1999Date of Patent: February 6, 2001Assignee: Molecumetics Ltd.Inventors: Michael Kahn, Masakatsu Eguchi, Hwa-Ok Kim, Marcin Stasiak
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Patent number: 6117896Abstract: .beta.-sheet mimetics and methods relating to the same are disclosed. The .beta.-sheet mimetics have utility as protease and kinase inhibitors, as well as inhibitors of transcription factors and protein-protein binding interactions. Methods of the invention include administration of a .beta.-sheet mimetic, or use of the same for the manufacture of a medicament for treatment of a variety of conditions associated with the targeted protease, kinase, transcription factor and/or protein-protein binding interaction.Type: GrantFiled: February 12, 1998Date of Patent: September 12, 2000Assignee: Molecumetics Ltd.Inventors: Maher N. Qabar, Michael K. McMillan, Michael S. Kahn, John E. Tulinsky, Cyprian O. Ogbu, Jessymol Mathew
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Patent number: 6020331Abstract: There are disclosed .beta.-sheet mimetics and methods relating to the same for imparting or stabilizing the .beta.-sheet structure of a peptide, protein or molecule. In one aspect, the .beta.-sheet mimetics are covalently attached at the end or within the length of the peptide or protein. The .beta.-sheet mimetics have utility as protease inhibitors generally, including activity as serine protease inhibitors such as thrombin, elastase and Factor X.Type: GrantFiled: January 20, 1998Date of Patent: February 1, 2000Assignee: Molecumetics, Ltd.Inventor: Michael Kahn
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Patent number: 6013458Abstract: Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetics have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetics of this invention are also disclosed, as well as methods for screening the same to identify biologically active members.Type: GrantFiled: April 30, 1997Date of Patent: January 11, 2000Assignee: Molecumetics, Ltd.Inventors: Michael Kahn, Masakatsu Eguchi, Hwa-Ok Kim
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Patent number: 5929237Abstract: Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetics have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetics of this invention are also disclosed, as well as methods for screening the same to identify biologically active members.Type: GrantFiled: October 27, 1995Date of Patent: July 27, 1999Assignee: Molecumetics Ltd.Inventor: Michael Kahn
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Patent number: 5859184Abstract: There are disclosed alpha-helix mimetics and methods relating to the same for imparting or stabilizing alpha-helicity to a peptide or protein. In one aspect, the alpha-helix mimetics contain eleven- to fourteen-membered rings covalently attached at the end or within the length of the peptide or protein. The alpha-helix mimetics render the resulting peptide or protein more stable with regard to thermal stability, as well as making the peptide or protein more resistant to proteolytic degradation. In addition, the alpha-helix mimetics may be used in standard peptide synthesis protocols.Type: GrantFiled: April 30, 1997Date of Patent: January 12, 1999Assignee: Molecumetics Ltd.Inventors: Michael Kahn, Hwa-Ok Kim, Jan Urban