Patents Assigned to Molecure S.A.
  • Arginase inhibitors and methods of use thereof
    Patent number: 12612420
    Abstract: The inventive compounds are small molecule therapeutics that are potent inhibitors of arginase 1 and arginase 2 activity. The invention also provides pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease or condition associated with arginase activity.
    Type: Grant
    Filed: December 22, 2021
    Date of Patent: April 28, 2026
    Assignee: Molecure S.A.
    Inventors: Anna Gzik, Jacek Chrzanowski, Bartlomiej Borek, Roman Blaszczyk, Jacek Olczak, Adam Golebiowski, Marcin Mikolaj Grzybowski, Paulina Pomper, Nazan Cemre Güner-Chalimoniuk, Kamil Lisiecki, Damian Kusmirek
  • Deubiquitinase inhibitors and methods of use thereof
    Patent number: 12404279
    Abstract: The inventive compounds are small molecule therapeutics that are potent inhibitors of USP7 activity. The invention also provides pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease, disorder, or condition associated with USP7 activity.
    Type: Grant
    Filed: December 22, 2022
    Date of Patent: September 2, 2025
    Assignee: Molecure S.A.
    Inventors: Jacek Chrzanowski, Julita Nowicka, Łukasz Joachimiak, Robert Koralewski, Sylwia Olejniczak, Marzena Mazur, Bartlomiej Borek, Anna Gzik, Krzysztof Matyszewski, Sylwia Ciastek-Iskrzycka, Piotr Niedziejko, Angelika Muchowicz, Zbigniew Zasłona, Roman Błaszczyk, Jacek Olczak, Adam Golebiowski
  • YKL-40 inhibitors and their therapeutic
    Patent number: 12325701
    Abstract: Disclosed are assays for screening active compounds interfering with interaction between chitinase-like protein YKL-40 and chitin oligomers, as well as interfering with interaction between chitinase-like protein YKL-40 and heparan sulfate. Moreover, disclosed are active compounds identified by these assays as inhibitors of chitinase-like protein YKL-40, their therapeutic applications, and their use in biosensors measuring the level of chitinase-like protein YKL-40 in biological samples.
    Type: Grant
    Filed: March 3, 2023
    Date of Patent: June 10, 2025
    Assignee: Molecure S.A.
    Inventors: Łukasz Krzemiński, Wojciech Czestkowski, Marzena Mazur, Gleb Andryianau, Sylwia Olejniczak, Michal Czesław Piotrowicz, Robert Koralewski, Elżbieta Pluta, Krzysztof Matyszewski, Michał Kowaiski, Barbara Dymek, Rafał Kozieł, Jacek Olozak, Adam Gołębiowski, Agnieszka Bartoszewicz, Katarzyna Krysztofiak
  • Process for the production of 5-(4-((2S,5S)-5-(4-chlorobenzyl)-2-methyl-morpholino)piperidin-1-yl)-1H-1,2,4-triazol-3-amine
    Patent number: 12319677
    Abstract: The present invention relates to a process for the synthesis of 5-(4-((2S,5S)-5-(4-chlorobenzyl)-2-methylmorpholino)piperidin-1-yl)-1H-1,2,4-triazol-3-amine in two hydrated crystalline forms and in one anhydrous crystalline form. The present invention further relates to methyl (Z)-4-((2S,5S)-5-(4-chlorobenzyl)-2-methylmorpholino)-N-cyanopiperidine-1-carbimidothioate which is an intermediate in this process.
    Type: Grant
    Filed: July 17, 2023
    Date of Patent: June 3, 2025
    Assignee: Molecure S.A.
    Inventors: Grzegorz Witkowski, Marta Magdycz, Magdalena Tyszkiewicz, Marcin Zakrzewski, Stanisław Pikul
  • Process for the production of 5-(4-((2S,5S)-5-(4-chlorobenzyl)-2-methyl-morpholino)piperidin-1-yl)-1H-1,2,4-triazol-3-amine
    Patent number: 11746107
    Abstract: The present invention relates to a process for the synthesis of 5-(4-((2S,5S)-5-(4-chlorobenzyl)-2-methylmorpholino)piperidin-1-yl)-1H-1,2,4-triazol-3-amine in two hydrated crystalline forms and in one anhydrous crystalline form. The present invention further relates to methyl (Z)-4-((2S,5S)-5-(4-chlorobenzyl)-2-methylmorpholino)-N-cyanopiperidine-1-carbimidothioate which is an intermediate in this process.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: September 5, 2023
    Assignee: Molecure S.A.
    Inventors: Grzegorz Witkowski, Marta Magdycz, Magdalena Tyszkiewicz, Marcin Zakrzewski, Stanislaw Pikul
  • Substituted amino triazoles useful as chitinase inhibitors
    Patent number: 11638707
    Abstract: Disclosed are amino triazole compounds of formula (I). These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.
    Type: Grant
    Filed: July 15, 2020
    Date of Patent: May 2, 2023
    Assignee: Molecure S.A.
    Inventors: Marzena Mazur, Gleb Andryianau, Lukasz Joachimiak, Wojciech Czestkowski, Michal Kowalski, Piotr Niedziejko, Sylwia Olejniczak, Krzysztof Matyszewski, Robert Koralewski, Jacek Olczak, Adam Golebiowski, Agnieszka Bartoszewicz