Patents Assigned to Monell Chemical Sense Center
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Patent number: 8460925Abstract: The invention provides methods of culturing mammalian taste cells, including taste receptor cells. Cells are maintained for a duration of up to three months and longer while maintaining molecular and functional characteristics of mature taste cells. The cells are cultured on coated cell culture vessels and, from first replacement of medium onwards, the medium is replaced in intervals of at least 5 days. The invention further provides isolation and culturing methods of taste cells wherein the time that the cells are exposed to isolation solution and proteolytic enzymes is minimized and the cells are cultured in coated culture vessels with the medium replaced in intervals of at least 5 days from first replacement onwards. The invention further provides cultured taste cells, transfection and assay methods, and taste cell assay buffers with an osmolarity of about 300-320 and pH of about 7.0-7.3.Type: GrantFiled: July 12, 2011Date of Patent: June 11, 2013Assignee: Monell Chemical Senses CenterInventors: Nancy Ellen Rawson, Mehmet Hakan Ozdener
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Publication number: 20130078351Abstract: The present invention is directed to compounds that increase the saltiness intensity of sodium chloride in human taste. Compositions and foods comprising these compounds are also described.Type: ApplicationFiled: February 3, 2011Publication date: March 28, 2013Applicant: Monell Chemical Senses CenterInventor: Joseph G. Brand
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Publication number: 20120184828Abstract: An olfactometer is disclosed. Such an olfactometer may include a control unit, an odor box, and a nose piece in communication with the odor box. The control unit may include a reservoir, and a compressor for supplying pressurized air to the reservoir. The odor box may include at least one compressed air actuated valve, and at least one odor canister in communication with the valve. A compressed air flow and a breathable air flow are both released from the reservoir and directed to the valve. The compressed air flow actuates the valve to thereby direct the breathable air to the odor canister to odorize the breathable air. The odorized breathable air is then directed to the nose piece.Type: ApplicationFiled: September 21, 2010Publication date: July 19, 2012Applicant: MONELL CHEMICAL SENSES CENTERInventors: Johan Nils Lundstrom, Amy Russell Gordon
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Publication number: 20120183975Abstract: The present invention relates to the discovery of several genes of the domestic dog (Canine familiaris) associated with taste perception. The invention provides, inter alia, the nucleotide sequence of the canine Tas1r1, Tas1r2, and Tas1r3 receptor genes, the amino acid sequences of the polypeptides encoded thereby, and antibodies to the polypeptides. The present invention also relates to methods for screening for compounds that modify the genes' function or activity, the compounds identified by such screens, and mimetics of the identified compounds. The invention further provides methods for modifying the taste preferences, ingestive responses, or general behavior of a mammal such as a dog by administering compounds that affect the function or activity of the gene or the polypeptide encoded thereby.Type: ApplicationFiled: March 28, 2012Publication date: July 19, 2012Applicant: MONELL CHEMICAL SENSES CENTERInventors: Xia Li, Weihua Li, Joseph G. Brand
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Publication number: 20120184459Abstract: The present invention relates to the discovery of several genes of the domestic cat (Felis catus) associated with taste perception. The invention provides, inter alia, the nucleotide sequence of the feline Tas1r1, Tas1r2, and Tas1r3 receptor genes, the amino acid sequences of the polypeptides encoded thereby, and antibodies to the polypeptides. The present invention also relates to methods for screening for compounds that modify the genes' function or activity, the compounds identified by such screens, and mimetics of the identified compounds. The invention further provides methods for modifying the taste preferences, ingestive responses, or general behavior of a mammal, such as a cat, by administering compounds that affect the function or activity of the gene or the polypeptide encoded thereby.Type: ApplicationFiled: March 26, 2012Publication date: July 19, 2012Applicant: MONELL CHEMICAL SENSES CENTERInventors: Xia Li, Weihua Li, Danielle R. Reed, Alexander A. Bachmanov, Joseph G. Brand
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Patent number: 8173769Abstract: The present invention relates to the discovery of several genes of the domestic cat (Felis catus) associated with taste perception. The invention provides, inter alia, the nucleotide sequence of the feline Tas1r1, Tas1r2, and Tas1r3 receptor genes, the amino acid sequences of the polypeptides encoded thereby, and antibodies to the polypeptides. The present invention also relates to methods for screening for compounds that modify the genes' function or activity, the compounds identified by such screens, and mimetics of the identified compounds. The invention further provides methods for modifying the taste preferences, ingestive responses, or general behavior of a mammal, such as a cat, by administering compounds that affect the function or activity of the gene or the polypeptide encoded thereby.Type: GrantFiled: March 18, 2009Date of Patent: May 8, 2012Assignee: Monell Chemical Senses CenterInventors: Xia Li, Weihua Li, Danielle R. Reed, Alexander A. Bachmanov, Joseph G. Brand
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Patent number: 8168395Abstract: The present invention relates to the discovery of several genes of the domestic dog (Canine familiaris) associated with taste perception. The invention provides, inter alia, the nucleotide sequence of the canine Tas1r1, Tas1r2, and Tas1r3 receptor genes, the amino acid sequences of the polypeptides encoded thereby, and antibodies to the polypeptides. The present invention also relates to methods for screening for compounds that modify the genes' function or activity, the compounds identified by such screens, and mimetics of the identified compounds. The invention further provides methods for modifying the taste preferences, ingestive responses, or general behavior of a mammal such as a dog by administering compounds that affect the function or activity of the gene or the polypeptide encoded thereby.Type: GrantFiled: April 23, 2009Date of Patent: May 1, 2012Assignee: Monell Chemical Senses CenterInventors: Xia Li, Weihua Li, Joseph G. Brand
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Publication number: 20110269235Abstract: The invention provides methods of culturing mammalian taste cells, including taste receptor cells. Cells are maintained for a duration of up to three months and longer while maintaining molecular and functional characteristics of mature taste cells. The cells are cultured on coated cell culture vessels and, from first replacement of medium onwards, the medium is replaced in intervals of at least 5 days. The invention further provides isolation and culturing methods of taste cells wherein the time that the cells are exposed to isolation solution and proteolytic enzymes is minimized and the cells are cultured in coated culture vessels with the medium replaced in intervals of at least 5 days from first replacement onwards. The invention further provides cultured taste cells, transfection and assay methods, and taste cell assay buffers with an osmolarity of about 300-320 and pH of about 7.0-7.3.Type: ApplicationFiled: July 12, 2011Publication date: November 3, 2011Applicant: MONELL CHEMICAL SENSES CENTERInventors: Nancy Ellen Rawson, Mehmet Hakan Ozdener
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Patent number: 8030068Abstract: The invention provides methods of culturing mammalian taste cells, including taste receptor cells. Cells are maintained for a duration of up to three months and longer while maintaining molecular and functional characteristics of mature taste cells. The cells are cultured on coated cell culture vessels and, from first replacement of medium onwards, the medium is replaced in intervals of at least 5 days. The invention further provides isolation and culturing methods of taste cells wherein the time that the cells are exposed to isolation solution and proteolytic enzymes is minimized and the cells are cultured in coated culture vessels with the medium replaced in intervals of at least 5 days from first replacement onwards. The invention further provides cultured taste cells, transfection and assay methods, and taste cell assay buffers with an osmolarity of about 300-320 and pH of about 7.0-7.3.Type: GrantFiled: January 2, 2009Date of Patent: October 4, 2011Assignee: Monell Chemical Senses CenterInventors: Nancy Ellen Rawson, Mehmet Hakan Ozdener
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Publication number: 20110236313Abstract: Methods for identifying modulators of the epithelial sodium ion channel and for identifying modulators of salty taste perception are described. Also featured are isolated human salty taste receptors, artificial lipid bilayers comprising an epithelial sodium ion channels, and kits for practicing the claimed methods.Type: ApplicationFiled: January 18, 2011Publication date: September 29, 2011Applicant: MONELL CHEMICAL SENSES CENTERInventors: Joseph G. Brand, Taufiqul Huque
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Patent number: 8008084Abstract: The present invention relates to a method for determining whether or not a mammal is affected with a lung cancer. The method for determining whether or not a mammal is affected with a lung cancer of the present invention includes the steps of: (a) measuring a concentration of 2-hydroxy-3-methylbutyric acid contained in the urine excreted from the mammal; and (b) determining that the mammal is affected with a lung cancer if the concentration measured in the step (a) is 13.2 ?M or more.Type: GrantFiled: April 23, 2010Date of Patent: August 30, 2011Assignees: Panasonic Corporation, Monell Chemical Senses CenterInventors: Yosuke Hanai, Yuki Sugibayashi
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Patent number: 7977054Abstract: Chemical field effect sensors comprising nanotube field effect devices having biopolymers such as single stranded DNA functionally adsorbed to the nanotubes are provided. Also included are arrays comprising the sensors and methods of using the devices to detect volatile compounds.Type: GrantFiled: March 29, 2006Date of Patent: July 12, 2011Assignees: The Trustees of the University of Pennsylvania, Monell Chemical Senses CenterInventors: Alan T. Johnson, Jr., Alan Gelperin, Cristian Staii
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Patent number: 7892756Abstract: Methods for identifying modulators of the epithelial sodium ion channel and for identifying modulators of salty taste perception are described. Also featured are isolated human salty taste receptors, artificial lipid bilayers comprising an epithelial sodium ion channels, and kits for practicing the claimed methods.Type: GrantFiled: October 19, 2007Date of Patent: February 22, 2011Assignee: Monell Chemical Senses CenterInventors: Joseph G. Brand, Taufiqul Huque
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Publication number: 20100319075Abstract: The present invention relates to a polynucleotide vector comprising the Simian taste-bud specific gene (STG) promoter operatively linked to a reporter gene. In preferred embodiments, the STG promoter is the murine ortholog of the STG promoter. In other preferred embodiments, the STG promoter is the human ortholog of the STG promoter. In some preferred embodiments, the reporter gene is green fluorescent protein (GFP). Additionally provided are vectors comprising the STG promoter operatively linked to a cre-recombinase gene.Type: ApplicationFiled: June 11, 2010Publication date: December 16, 2010Applicant: MONELL CHEMICAL SENSES CENTERInventors: Alexander Alexeyevich Bachmanov, Nataliya Petrovna Bosak, Yutaka Ishiwatari
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Publication number: 20100254927Abstract: Deodorant compositions are disclosed comprising a cross-adapting agent, alone or in combination with other such agents, in an amount effective to reduce perception of malodor. Deodorant compositions are also disclosed comprising a cross-adapting agent, alone or in combination with other such agents, in an amount effective to reduce perception of gender-specific malodor. The methods feature reducing perceived body odor comprising administering a deodorant composition wherein the composition comprises an amount of cross-adapting agent effective to reduce perception of such odor. Other methods feature blocking perceived body odor comprising administering a deodorant composition wherein the composition comprises an amount of cross-adapting agent effective to occupy an odorant receptor site, thereby blocking interaction of the site with other odorants.Type: ApplicationFiled: June 16, 2010Publication date: October 7, 2010Applicants: Monell Chemical Senses Center, Symrise, Inc.Inventors: George Preti, Charles J. Wysocki, Leslie C. Smith, Keith J. McDermott
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Patent number: 7785807Abstract: The invention provides a novel splice-variant of the ClC-4 protein, termed ClC-4A. ClC-4A is expressed in taste bud cells and is involved in sour taste perception. The invention provides ClC-4A polynucleotides and ClC-4A polypeptides, vectors, host cells and ClC-4A specific antibodies as well as designing high potency taste stimuli, determining taste preferences in animals, developing breed-specific foods, and modifying the taste of foods and medications.Type: GrantFiled: December 13, 2005Date of Patent: August 31, 2010Assignee: Monell Chemical Senses CenterInventors: Liquan Huang, Jie Cao, Hong Wang, Joseph G Brand
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Patent number: 7763238Abstract: Deodorant compositions are disclosed comprising a cross-adapting agent, alone or in combination with other such agents, in an amount effective to reduce perception of malodor. Deodorant compositions are also disclosed comprising a cross-adapting agent, alone or in combination with other such agents, in an amount effective to reduce perception of gender-specific malodor. The methods feature reducing perceived body odor comprising administering a deodorant composition wherein the composition comprises an amount of cross-adapting agent effective to reduce perception of such odor. Other methods feature blocking perceived body odor comprising administering a deodorant composition wherein the composition comprises an amount of cross-adapting agent effective to occupy an odorant receptor site, thereby blocking interaction of the site with other odorants.Type: GrantFiled: January 15, 2003Date of Patent: July 27, 2010Assignees: Monell Chemical Senses Center, Symrise Inc.Inventors: George Preti, Charles J. Wysocki, Leslie C. Smith, Keith J. McDermott
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Publication number: 20090233379Abstract: The present invention relates to the discovery of several genes of the domestic dog (Canine familiaris) associated with taste perception. The invention provides, inter alia, the nucleotide sequence of the canine Tas1r1, Tas1r2, and Tas1r3 receptor genes, the amino acid sequences of the polypeptides encoded thereby, and antibodies to the polypeptides. The present invention also relates to methods for screening for compounds that modify the genes' function or activity, the compounds identified by such screens, and mimetics of the identified compounds. The invention further provides methods for modifying the taste preferences, ingestive responses, or general behavior of a mammal such as a dog by administering compounds that affect the function or activity of the gene or the polypeptide encoded thereby.Type: ApplicationFiled: April 23, 2009Publication date: September 17, 2009Applicant: Monell Chemical Senses CenterInventors: Xia Li, Weihua Li, Joseph G. Brand
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Publication number: 20090205061Abstract: The present invention relates to the discovery of several genes of the domestic cat (Felis catus) associated with taste perception. The invention provides, inter alia, the nucleotide sequence of the feline Tas1r1, Tas1r2, and Tas1r3 receptor genes, the amino acid sequences of the polypeptides encoded thereby, and antibodies to the polypeptides. The present invention also relates to methods for screening for compounds that modify the genes' function or activity, the compounds identified by such screens, and mimetics of the identified compounds. The invention further provides methods for modifying the taste preferences, ingestive responses, or general behavior of a mammal, such as a cat, by administering compounds that affect the function or activity of the gene or the polypeptide encoded thereby.Type: ApplicationFiled: March 18, 2009Publication date: August 13, 2009Applicant: Monell Chemical Senses CenterInventors: Xia Li, Weihua Li, Danielle R. Reed, Alexander A. Bachmanov, Joseph G. Brand
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Patent number: 7541158Abstract: The present invention relates to the discovery of several genes of the domestic dog (Canine familiaris) associated with taste perception. The invention provides, inter alia, the nucleotide sequence of the canine Tas1r1, Tas1r2, and Tas1r3 receptor genes, the amino acid sequences of the polypeptides encoded thereby, and antibodies to the polypeptides. The present invention also relates to methods for screening for compounds that modify the genes' function or activity, the compounds identified by such screens, and mimetics of the identified compounds. The invention further provides methods for modifying the taste preferences, ingestive responses, or general behavior of a mammal such as a dog by administering compounds that affect the function or activity of the gene or the polypeptide encoded thereby.Type: GrantFiled: April 14, 2005Date of Patent: June 2, 2009Assignee: Monell Chemical Senses CenterInventors: Xia Li, Weihua Li, Joseph G. Brand