Patents Assigned to Montana Molecular LLC
  • Genetically encoded fluorescent sensors for detecting ligand bias and intracellular signaling through cAMP pathways
    Patent number: 11366114
    Abstract: Described herein are novel fluorescent sensors for cyclic adenosine monophosphate (cAMP) that are based on single fluorescent proteins. These sensors use less visible spectrum than FRET-based sensors, produce robust changes in fluorescence, and can be combined with one another, or with other sensors, in a multiplex assay on standard fluorescent plate readers or live cell imaging systems.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: June 21, 2022
    Assignee: Montana Molecular LLC
    Inventors: Thomas E. Hughes, Paul H. Tewson, Anne Marie Quinn
  • Genetically encoded fluorescent sensors for detecting intracellular signalling through diacylglycerol pathways
    Patent number: 10131960
    Abstract: Described herein are novel fluorescent sensors for Diacyl Glycerol (DAG) and phosphatidylinositol 4,5-bisphosphate (PIP2) that are based on circularly permuted fluorescent proteins. These sensors use less visible spectrum than FRET-based sensors, produce robust changes in fluorescence, and can be combined with one another, or with other sensors, in a multiplex assay on standard fluorescent plate readers or live cell imaging systems.
    Type: Grant
    Filed: January 16, 2017
    Date of Patent: November 20, 2018
    Assignee: Montana Molecular LLC
    Inventors: Thomas E. Hughes, Paul H. Tewson, Anne Marie Quinn
  • Genetically encoded fluorescent sensors for detecting intracellular signalling through diacylglycerol pathways
    Patent number: 9547017
    Abstract: Described herein are novel fluorescent sensors for Diacyl Glycerol (DAG) and hosphatidylinositol 4,5-bisphosphate (PIP2) that are based on circularly permuted fluorescent proteins. These sensors use less visible spectrum than FRET-based sensors, produce robust changes in fluorescence, and can be combined with one another, or with other sensors, in a multiplex assay on standard fluorescent plate readers or live cell imaging systems.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: January 17, 2017
    Assignee: Montana Molecular LLC
    Inventors: Thomas E. Hughes, Paul H. Tewson, Anne Marie Quinn