Patents Assigned to Montana State University
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Patent number: 12319385Abstract: Wettable structures that retain liquid layers are defined at surfaces of substrates. The wettable structures include grooves or ridges that are spaced apart by between 10 nm and 10 ?m and can be defined in substrate or in a layer formed on a surface of the substrate. In typical examples, wettable structures are defined with hydrophobic materials or at hydrophobic surfaces and produce hydrophilic surfaces.Type: GrantFiled: May 11, 2022Date of Patent: June 3, 2025Assignees: Montana State University, Board of Regents of the University of NebraskaInventors: Leon G. Higley, Robert K. D. Peterson
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Publication number: 20250066752Abstract: CRISPR RNA-guided nucleases are routinely used for sequence-specific manipulation of DNA. While CRISPR-based DNA editing has become routine, analogous methods for editing RNA have yet to be established. Here we repurpose the type III-A CRISPR RNA-guided nuclease for sequence-specific cleavage of the SARS-COV-2 genome. The type III cleavage reaction is performed in vitro using purified viral RNA, resulting in sequence-specific excision of 6, 12, 18 or 24 nucleotides. Ligation of the cleavage products is facilitated by a DNA splint that bridges the excision and RNA ligase is used to link the RNA products before transfection into mammalian cells. The SARS-COV-2 RNA is infectious and standard plaque assays are used to recover viral clones. Collectively, this work demonstrates how type III CRISPR systems can be repurposed for sequence-specific editing of RNA viruses including SARS-COV-2 and more generally for gene therapy.Type: ApplicationFiled: October 2, 2024Publication date: February 27, 2025Applicant: Montana State UniversityInventors: Blake A. WIEDENHEFT, Joseph E. NICHOLS, Anna A. NEMUDRAIA, Artem A. NEMUDRYI
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Patent number: 12061287Abstract: A beam transmitter, a receiver, and a LIDAR, along with methods to operate each are provided. The beam transmitter comprises a first and a second transmission channel (201a, 201b), each transmission channel including a first online laser, a first offline laser, and a first laser transmission selection switch operable to toggle between including the first online laser signal and the first offline laser signal in a first transmission beam. The beam transmitter further includes at least one light redirection device operable to coalign the first transmission beam with the second transmission beam. The receiver comprises a first splitter (402a, 402b), a first filter (404a, 404b), a first detector channel (406a, 406b), a second splitter (408a, 408b), a second filter (410a, 410b), and a second detector channel (412a, 412b). The LIDAR includes the beam transmitter, the receiver, and a shared telescope.Type: GrantFiled: November 30, 2018Date of Patent: August 13, 2024Assignees: University Corporation for Atmospheric Research, Montana State UniversityInventors: Robert Stillwell, Scott Spuler, Matthew Hayman, Kevin S. Repasky
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Patent number: 12009475Abstract: This disclosure provides systems, methods, and apparatus related to an all-solid-state battery including a solid electrolyte. In one aspect, a device includes a first layer of an ionically conducting oxide, a second layer of the ionically conducting oxide disposed on the first layer, and an anode disposed on the second layer of the ionically conducting oxide. The first layer defines through pores having a tortuosity of about 1. The first layer includes transition metal oxide particles and an ionically conducting solid disposed in the through pores. The transition metal oxide particles are a cathode. The first layer and the ionically conducting solid are an electrolyte. The second layer does not define any through pores. The second layer is a separator.Type: GrantFiled: November 11, 2020Date of Patent: June 11, 2024Assignees: The Regents of the University of California, Montana State UniversityInventors: Eongyu Yi, Marca Doeff, Guoying Chen, Stephen Sofie
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Publication number: 20240182988Abstract: The disclosure relates to engineered systems and methods for detecting target nucleic acid in a sample, which may be a complex mixture. The systems and methods may improve sensitivity of target nucleic acid detection by enhancing signal generation. For example, signal generation may be enhanced through programmable capture and concentration of the target nucleic acid using an engineered type III CRISPR complex. Various ancillary nucleases such as Can1, Can2, and NucC are identified and may be used for detection. For example, binding of the engineered type III CRISPR complex may produce products that activate the identified ancillary nucleases. Different activators trigger changes in the substrate specificity of these nucleases. The activated nucleases may be used to detect programmatic detection of the target nucleic in the sample. The systems and methods are shown to detect viral RNA directly from nasopharyngeal swab samples.Type: ApplicationFiled: June 8, 2023Publication date: June 6, 2024Applicant: Montana State UniversityInventors: Blake A. WIEDENHEFT, Andrew SANTIAGO-FRANGOS, Anna A. NEMUDRAIA, Artem A. NEMUDRYI
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Patent number: 11859145Abstract: An improved alkaline pretreatment of biomass is provided that is a single-stage, two oxidant alkaline oxidative pretreatment process. The process uses a homogenous catalyst with at least two oxidants (Hydrogen peroxide and enhanced levels of oxygen) in an alkaline environment to catalytically pretreat lignocellulosic biomass in a single-stage oxidation reaction. The provided single-stage alkaline-oxidative pretreatment improves biomass pretreatment and increase enzymatic digestibility to improve the economic feasibility of production of lignocellulose derived sugars.Type: GrantFiled: August 29, 2022Date of Patent: January 2, 2024Assignees: Board of Trustees of Michigan State University, Montana State University, Wisconsin Alumni Research FoundationInventors: Eric L. Hegg, Zhaoyang Yuan, David B. Hodge, Shannon S. Stahl, Bryan D. Bals
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Publication number: 20230243853Abstract: The present invention provides methods for identifying biomarkers of disease capable of affecting cognitive function. The biomarkers identified by the methods of the prevention may be used for predicting whether a mammal will develop a disease capable of affecting cognitive function. More specifically, the present invention relates to the identification of biomarkers predictive of neurological diseases in a mammal and the use of these biomarkers in the diagnosis, differential diagnosis, and/or prognosis of the neurological disease. The methods and systems provided enable an assessment and theoretical prediction of neocortical amyloid loading based on the measurement of biomarkers that will provide an indication of whether a mammal is likely to develop a neurological disease.Type: ApplicationFiled: August 17, 2022Publication date: August 3, 2023Applicants: CRC for Mental Health Ltd, Montana State UniversityInventors: Blaine Roberts, Edward A. Dratz, Scott Laffoon
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Publication number: 20230212701Abstract: The present disclosure generally relates to systems and methods for detecting viruses, e.g., using microfluidic devices. Certain embodiments are generally directed to systems and methods that are able to detect pathogens such as viruses or bacteria by encapsulating a sample in droplets, and applying amplification reagents to the droplets able to amplify nucleic acids therein, e.g., using loop mediated isothermal amplification (LAMP) or other amplification techniques. In addition, some aspects are generally directed to identifying a species in a sample, e.g., at very low concentrations. In some cases, the sample may be broken into droplets, arid the droplets determined to determine the species.Type: ApplicationFiled: April 27, 2021Publication date: July 6, 2023Applicants: President and Fellows of Harvard College, Montana State UniversityInventors: David A. Weitz, Connie Chang Wilking, Dimitri A. Bikos, Emma Kate Loveday, Geoffrey K. Zath
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Publication number: 20220363343Abstract: Wettable structures that retain liquid layers are defined at surfaces of substrates. The wettable structures include grooves or ridges that are spaced apart by between 10 nm and 10 ?m and can be defined in substrate or in a layer formed on a surface of the substrate. In typical examples, wettable structures are defined with hydrophobic materials or at hydrophobic surfaces and produce hydrophilic surfaces.Type: ApplicationFiled: May 11, 2022Publication date: November 17, 2022Applicant: Montana State UniversityInventors: Leon G. Higley, Robert K. D. Peterson
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Publication number: 20220280580Abstract: The present disclosure relates generally to therapeutic compositions comprising recombinant bacteria. Further, the disclosure elaborates upon methods of utilizing the herein described therapeutic compositions to treat autoimmune and inflammatory disease. The present teachings also relate to the disclosed recombinant bacteria and methods of producing the recombinant bacteria utilized in the compositions and methods. Further taught herein are dietary supplements and food additive compositions comprising the taught recombinant bacteria.Type: ApplicationFiled: August 28, 2020Publication date: September 8, 2022Applicant: Montana State UniversityInventors: David Pascual, Massimo Maddaloni
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Patent number: 11367551Abstract: Large magnetic moment compositions are formed by stabilizing ternary or other alloys with a epitaxial control layer. Compositions that are unstable in bulk specimen are thus stabilized and exhibit magnetic moments that are greater that a Slater-Pauling limit. In one example, FexCoyMnz layers are produced on an MgO(001) substrate with an MgO surface serving to control the structure of the FexCoyMnz layers. Magnetizations greater than 3 Bohr magnetons are produced.Type: GrantFiled: December 14, 2018Date of Patent: June 21, 2022Assignees: Montana State University, The Regents of The University of CaliforniaInventors: Ryan J. Snow, Yves U. Idzerda, Elke Arenholz
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Patent number: 11243295Abstract: A filter for a micropulse differential absorption LIDAR is provided. The filter comprises an etalon including a free spectral range substantially the same as a difference between a first laser wavelength and a second laser wavelength, the etalon further including a finesse providing substantial background noise suppression and substantially constant transmission of the first laser wavelength and the second laser wavelength over a predetermined range of wavelengths, and a first filter having a first filter bandpass selected to include the first laser wavelength and the second laser wavelength.Type: GrantFiled: June 28, 2018Date of Patent: February 8, 2022Assignees: University Corporation for Atmospheric Research, Montana State University, NASA Langley Research CenterInventors: Scott M. Spuler, Kevin S. Repasky, Amin R. Nehrir
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Patent number: 11208642Abstract: Disclosed herein are compositions of non-naturally occurring enzymes to enable microbial syringol utilization with GcoAB.Type: GrantFiled: November 14, 2019Date of Patent: December 28, 2021Assignees: Alliance for Sustainable Energy, LLC, Montana State University, University of PortsmouthInventors: Gregg Tyler Beckham, Jennifer DuBois, Melodie M. Machovina, Simon James Bradshaw Mallinson, John E. McGeehan, Christopher W. Johnson, Alexander William Meyers
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Patent number: 11143748Abstract: A shared optics and telescope for transmitting a transmission beam and receiving a return signal is provided. The shared optics and telescope includes a pair of axicon lenses operable to shape the transmission beam into an annular beam having an outer diameter and an inner diameter, a secondary mirror operable to deflect the annular beam into a deflected annular transmission beam, and a primary mirror that includes an inner mirror portion and an outer mirror portion, the inner mirror portion operable to expand the deflected annular transmission beam, and the outer mirror portion operable to collect the return signal.Type: GrantFiled: June 29, 2018Date of Patent: October 12, 2021Assignees: University Corporation for Atmospheric Research, Montana State University, NASA Langley Research CenterInventor: Scott M. Spuler
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CONTINUOUS LATERAL PORE GRADING FOR SCALABLE EFFICIENCY OF MEMBRANES IN ELECTROCHEMICAL APPLICATIONS
Publication number: 20210162351Abstract: Processes for manufacturing continuous laterally graded porous membranes are disclosed. Such processes utilize freeze casting techniques with a continuous varying solids loading method to make laterally graded porous membranes. Also disclosed are laterally graded porous membranes.Type: ApplicationFiled: September 9, 2019Publication date: June 3, 2021Applicant: Montana State UniversityInventors: Stephen W. Sofie, Lee H. Spangler -
Patent number: 10877049Abstract: Biomarkers associated with neuroimmunological disease are described. The disclosed biomarkers are secreted proteins identified in cerebral spinal fluid (CSF) samples of patients with neurological disease. The disclosed biomarkers identify patients with intrathecal inflammation, distinguish multiple sclerosis (MS) patients from patients with other types of inflammatory neurological diseases and from subjects without MS, distinguish progressive MS patients from patients with relapsing-remitting MS, identify subjects with non-MS inflammatory neurological diseases, differentiate healthy subjects from patients with any type of neurological disease, and/or identify subjects with increased disability, CNS tissue damage and/or neurodegeneration. Process-specific biomarkers that can be used in place of a brain biopsy to identify immune cell infiltration and/or activation in the CNS are also described.Type: GrantFiled: February 25, 2019Date of Patent: December 29, 2020Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Montana State UniversityInventors: Bibiana Bielekova, Mika Komori, Peter Kosa, Mark C. Greenwood, Christopher Barbour
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Publication number: 20200312510Abstract: Large magnetic moment compositions are formed by stabilizing ternary or other alloys with a epitaxial control layer. Compositions that are unstable in bulk specimen are thus stabilized and exhibit magnetic moments that are greater that a Slater-Pauling limit. In one example, FexCoyMnz layers are produced on an MgO(001) substrate with an MgO surface serving to control the structure of the FexCoyMnz layers. Magnetizations greater than 3 Bohr magnetons are produced.Type: ApplicationFiled: December 14, 2018Publication date: October 1, 2020Applicants: Montana State University, The Regents of The University of CaliforniaInventors: Ryan J. Snow, Yves U. Idzerda, Elke Arenholz
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Patent number: 10605900Abstract: A shared optics and telescope, a filter, and a micropulse differential absorption LIDAR are provided, with methods to use the same. The shared optics and telescope includes a pair of axicon lenses, a secondary mirror, a primary mirror including an inner mirror portion and an outer mirror portion, the inner mirror portion operable to expand the deflected annular transmission beam, and the outer mirror portion operable to collect the return signal. The filter includes an etalon and a first filter. The micropulse differential absorption LIDAR includes first and second laser signals, a laser transmission beam selection switch, a first laser return signal switch, and a toggle timer.Type: GrantFiled: April 27, 2016Date of Patent: March 31, 2020Assignees: University Corporation for Atmospheric Research, Montana State University, NASA Langley Research CenterInventors: Scott M Spuler, Kevin S Repasky, Amin R Nehrir
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Publication number: 20190265254Abstract: Biomarkers associated with neuroimmunological disease are described. The disclosed biomarkers are secreted proteins identified in cerebral spinal fluid (CSF) samples of patients with neurological disease. The disclosed biomarkers identify patients with intrathecal inflammation, distinguish multiple sclerosis (MS) patients from patients with other types of inflammatory neurological diseases and from subjects without MS, distinguish progressive MS patients from patients with relapsing-remitting MS, identify subjects with non-MS inflammatory neurological diseases, differentiate healthy subjects from patients with any type of neurological disease, and/or identify subjects with increased disability, CNS tissue damage and/or neurodegeneration. Process-specific biomarkers that can be used in place of a brain biopsy to identify immune cell infiltration and/or activation in the CNS are also described.Type: ApplicationFiled: February 25, 2019Publication date: August 29, 2019Applicants: The U.S.A., as represented by the Secretary, Department of Health and Human Services, Montana State UniversityInventors: Bibiana Bielekova, Mika Komori, Peter Kosa, Mark C. Greenwood, Christopher Barbour
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Patent number: 10307527Abstract: Systems, compositions, methods and kits employ protein shells, such as ferritin or viral capsid shells, herein called nanobubbles, to enhance X-ray images of cells or body tissue under certain x-ray imaging methods. The nanobubbles have sub-micron size such as about 10 nm, about 40, 60, or 100 nm and may be functionalized for effective delivery to or uptake by a target tissue, in vivo or a cell culture. The nanobubbles are hollow, having a central core which may be empty or contain a fluid, such that the shells effectively form long-lived bubbles in the imaged environment, and are of low electron density and have different scattering properties than the surrounding tissue. X-ray imaging by spatial frequency heterodyne imaging enhances visualization or detection of tissue regions bearing the shells. The protein shells may be further treated to assure biocompatibility and/or to resist undesired interactions with non-targeted tissue, such as scavenging by the liver, or attack by the immune system.Type: GrantFiled: April 21, 2015Date of Patent: June 4, 2019Assignees: Brown University, Montana State UniversityInventors: Christoph Rose-Petruck, Trevor Douglas, Danielle Rand, Masaki Uchida