Patents Assigned to Montana State University
  • Patent number: 11367551
    Abstract: Large magnetic moment compositions are formed by stabilizing ternary or other alloys with a epitaxial control layer. Compositions that are unstable in bulk specimen are thus stabilized and exhibit magnetic moments that are greater that a Slater-Pauling limit. In one example, FexCoyMnz layers are produced on an MgO(001) substrate with an MgO surface serving to control the structure of the FexCoyMnz layers. Magnetizations greater than 3 Bohr magnetons are produced.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: June 21, 2022
    Assignees: Montana State University, The Regents of The University of California
    Inventors: Ryan J. Snow, Yves U. Idzerda, Elke Arenholz
  • Publication number: 20220169908
    Abstract: Methods of conducting ureolysis-induced calcium carbonate precipitation with a heat-treated cell preparation, methods for preparing the heat-treated cell preparation, and related materials. The methods of conducting ureolysis-induced calcium carbonate precipitation include precipitating calcium carbonate at a location by introducing urea, calcium, and a heat-treated cell preparation comprising active urease enzyme to the location. The urease enzyme hydrolyzes the urea to ammonium carbonate, and the calcium reacts with the carbonate to form a calcium carbonate precipitate at the location.
    Type: Application
    Filed: March 25, 2020
    Publication date: June 2, 2022
    Applicants: MONTANA STATE UNIVERSITY, MONTANA EMERGENT TECHNOLOGIES, INC.
    Inventors: Adrienne J. PHILLIPS, Robin GERLACH, Alfred B. CUNNINGHAM, Lee H. SPANGLER, Arda AKYEL, Catherrin M. KIRKLAND, Dwight Randall HIEBERT
  • Patent number: 11300774
    Abstract: Handheld devices and methods that integrate wide-field dermoscopy with reflectance confocal microscopy for non-invasive simultaneous capture of wide-field color images of the skin surface and images of the sub-surface cellular structure.
    Type: Grant
    Filed: February 11, 2017
    Date of Patent: April 12, 2022
    Assignees: MONTANA STATE UNIVERSITY, MEMORIAL SLOAN-KETTERING CANCER CENTER
    Inventors: David Dickensheets, Milind Rajadhyaksha
  • Publication number: 20220071999
    Abstract: Described are compounds and compositions that inhibit or target Cyt-bd, and methods of making, using, and assaying same. Also disclosed are compositions, methods and kits including the compounds and compositions that inhibit or target Cyt-bd, and one or more Cyt-bc1:aa3 inhibitor, F1F0-ATP synthase inhibitor, NADH dehydrogenase (NDH-2) inhibitor, NADH dehydrogenase (NDH-2) activator or antibacterial agent.
    Type: Application
    Filed: December 19, 2019
    Publication date: March 10, 2022
    Applicants: UNIVERSITY OF NOTRE DAME DU LAC, MONTANA STATE UNIVERSITY, NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: Marvin J. MILLER, Garrett C. MORASKI, Kevin PETHE
  • Patent number: 11243295
    Abstract: A filter for a micropulse differential absorption LIDAR is provided. The filter comprises an etalon including a free spectral range substantially the same as a difference between a first laser wavelength and a second laser wavelength, the etalon further including a finesse providing substantial background noise suppression and substantially constant transmission of the first laser wavelength and the second laser wavelength over a predetermined range of wavelengths, and a first filter having a first filter bandpass selected to include the first laser wavelength and the second laser wavelength.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: February 8, 2022
    Assignees: University Corporation for Atmospheric Research, Montana State University, NASA Langley Research Center
    Inventors: Scott M. Spuler, Kevin S. Repasky, Amin R. Nehrir
  • Publication number: 20210405207
    Abstract: A beam transmitter, a receiver, and a LIDAR, along with methods to operate each are provided. The beam transmitter comprises a first and a second transmission channel (201a, 201b), each transmission channel including a first online laser, a first offline laser, and a first laser transmission selection switch operable to toggle between including the first online laser signal and the first offline laser signal in a first transmission beam. The beam transmitter further includes at least one light redirection device operable to coalign the first transmission beam with the second transmission beam. The receiver comprises a first splitter (402a, 402b), a first filter (404a, 404b), a first detector channel (406a, 406b), a second splitter (408a, 408b), a second filter (410a, 410b), and a second detector channel (412a, 412b). The LIDAR includes the beam transmitter, the receiver, and a shared telescope.
    Type: Application
    Filed: November 30, 2018
    Publication date: December 30, 2021
    Applicants: UNIVERSITY CORPORATION FOR ATMOSPHERIC RESEARCH, MONTANA STATE UNIVERSITY
    Inventors: Robert STILLWELL, Scott SPULER, Matthew HAYMAN, Kevin S. REPASKY
  • Patent number: 11208642
    Abstract: Disclosed herein are compositions of non-naturally occurring enzymes to enable microbial syringol utilization with GcoAB.
    Type: Grant
    Filed: November 14, 2019
    Date of Patent: December 28, 2021
    Assignees: Alliance for Sustainable Energy, LLC, Montana State University, University of Portsmouth
    Inventors: Gregg Tyler Beckham, Jennifer DuBois, Melodie M. Machovina, Simon James Bradshaw Mallinson, John E. McGeehan, Christopher W. Johnson, Alexander William Meyers
  • Publication number: 20210332446
    Abstract: The disclosure relates to an engineered type III CRISPR-Cas system for sensitive and sequence specific detection of nucleic acid in a sample. For example, the engineered type III CRISPR-Cas system may be implemented as an assay for testing SARS-CoV-2 virus (or other target nucleic acid in the sample) that can be performed quickly, such as in one hour or less. Nucleic acid recognition by type III systems may trigger Cas10-mediated nuclease activity and/or polymerase activity, which may generate pyrophosphates, protons and cyclic oligonucleotides. The nuclease activity and/or the one or more products of the Cas10-polymerase are detected using colorimetric, visible fluorometric, and/or instrumented fluorometric detection.
    Type: Application
    Filed: April 26, 2021
    Publication date: October 28, 2021
    Applicant: MONTANA STATE UNIVERSITY
    Inventors: Blake A. WIEDENHEFT, Andrew SANTIAGO-FRANGOS, Anna A. NEMUDRAIA, Artem A. NEMUDRYI
  • Patent number: 11150536
    Abstract: Techniques for generating an arbitrary target electromagnetic signal with a nonlinear material, include determining a time varying target amplitude and target phase and an order n of a nonlinear material. For each time, a first set of nth roots of the target amplitude and a second set of nth roots of the target phase are determined. An input amplitude based on one value from the first set and an input phase based on one value from the second set is determined at each time. A difference between temporally successive values of phase is minimized. An electromagnetic signal is modulated to impose the input amplitude and phase to produce a modulated electromagnetic input signal that is introduced into the nonlinear material to produce a target electromagnetic signal.
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: October 19, 2021
    Assignees: S2 CORPORATION, MONTANA STATE UNIVERSITY
    Inventors: Zeb William Barber, Calvin Harrington, Krishna Mohan Rupavatharam, Peter B. Sellin, Craig Benko
  • Patent number: 11143748
    Abstract: A shared optics and telescope for transmitting a transmission beam and receiving a return signal is provided. The shared optics and telescope includes a pair of axicon lenses operable to shape the transmission beam into an annular beam having an outer diameter and an inner diameter, a secondary mirror operable to deflect the annular beam into a deflected annular transmission beam, and a primary mirror that includes an inner mirror portion and an outer mirror portion, the inner mirror portion operable to expand the deflected annular transmission beam, and the outer mirror portion operable to collect the return signal.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: October 12, 2021
    Assignees: University Corporation for Atmospheric Research, Montana State University, NASA Langley Research Center
    Inventor: Scott M. Spuler
  • Publication number: 20210162351
    Abstract: Processes for manufacturing continuous laterally graded porous membranes are disclosed. Such processes utilize freeze casting techniques with a continuous varying solids loading method to make laterally graded porous membranes. Also disclosed are laterally graded porous membranes.
    Type: Application
    Filed: September 9, 2019
    Publication date: June 3, 2021
    Applicant: Montana State University
    Inventors: Stephen W. Sofie, Lee H. Spangler
  • Patent number: 10877049
    Abstract: Biomarkers associated with neuroimmunological disease are described. The disclosed biomarkers are secreted proteins identified in cerebral spinal fluid (CSF) samples of patients with neurological disease. The disclosed biomarkers identify patients with intrathecal inflammation, distinguish multiple sclerosis (MS) patients from patients with other types of inflammatory neurological diseases and from subjects without MS, distinguish progressive MS patients from patients with relapsing-remitting MS, identify subjects with non-MS inflammatory neurological diseases, differentiate healthy subjects from patients with any type of neurological disease, and/or identify subjects with increased disability, CNS tissue damage and/or neurodegeneration. Process-specific biomarkers that can be used in place of a brain biopsy to identify immune cell infiltration and/or activation in the CNS are also described.
    Type: Grant
    Filed: February 25, 2019
    Date of Patent: December 29, 2020
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Montana State University
    Inventors: Bibiana Bielekova, Mika Komori, Peter Kosa, Mark C. Greenwood, Christopher Barbour
  • Publication number: 20200312510
    Abstract: Large magnetic moment compositions are formed by stabilizing ternary or other alloys with a epitaxial control layer. Compositions that are unstable in bulk specimen are thus stabilized and exhibit magnetic moments that are greater that a Slater-Pauling limit. In one example, FexCoyMnz layers are produced on an MgO(001) substrate with an MgO surface serving to control the structure of the FexCoyMnz layers. Magnetizations greater than 3 Bohr magnetons are produced.
    Type: Application
    Filed: December 14, 2018
    Publication date: October 1, 2020
    Applicants: Montana State University, The Regents of The University of California
    Inventors: Ryan J. Snow, Yves U. Idzerda, Elke Arenholz
  • Patent number: 10702514
    Abstract: Disclosed is the use of O-(3-piperidino-2-hydroxy-1-propyl)-nicotinic amidoxime (BGP15), its tautomers, enantiomers and pharmaceutically acceptable salts thereof for the treatment of Familial Dysaustonomia.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: July 7, 2020
    Assignees: N-GENE RESEARCH LABORATORIES, INC., MONTANA STATE UNIVERSITY
    Inventors: Frances Brenda Lefcort, Michael Jay Brownstein
  • Patent number: 10605900
    Abstract: A shared optics and telescope, a filter, and a micropulse differential absorption LIDAR are provided, with methods to use the same. The shared optics and telescope includes a pair of axicon lenses, a secondary mirror, a primary mirror including an inner mirror portion and an outer mirror portion, the inner mirror portion operable to expand the deflected annular transmission beam, and the outer mirror portion operable to collect the return signal. The filter includes an etalon and a first filter. The micropulse differential absorption LIDAR includes first and second laser signals, a laser transmission beam selection switch, a first laser return signal switch, and a toggle timer.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: March 31, 2020
    Assignees: University Corporation for Atmospheric Research, Montana State University, NASA Langley Research Center
    Inventors: Scott M Spuler, Kevin S Repasky, Amin R Nehrir
  • Patent number: 10527729
    Abstract: Laser 3D imaging techniques include splitting a laser temporally-modulated waveform of bandwidth B and duration D from a laser source into a reference beam and a target beam and directing the target beam onto a target. First data is collected, which indicates amplitude and phase of light relative to the reference beam received at each of a plurality of different times during a duration D at each optical detector of an array of one or more optical detectors perpendicular to the target beam. Steps are repeated for multiple sampling conditions, and the first data for the multiple sampling conditions are synthesized to form one or more synthesized sets. A 3D Fourier transform of each synthesized set forms a digital model of the target for each synthesized set with a down-range resolution based on the bandwidth B.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: January 7, 2020
    Assignees: BLACKMORE SENSORS AND ANALYTICS, LLC, MONTANA STATE UNIVERSITY
    Inventors: Stephen C. Crouch, Brant M. Kaylor, Zeb W. Barber, Randy R. Reibel
  • Publication number: 20190265254
    Abstract: Biomarkers associated with neuroimmunological disease are described. The disclosed biomarkers are secreted proteins identified in cerebral spinal fluid (CSF) samples of patients with neurological disease. The disclosed biomarkers identify patients with intrathecal inflammation, distinguish multiple sclerosis (MS) patients from patients with other types of inflammatory neurological diseases and from subjects without MS, distinguish progressive MS patients from patients with relapsing-remitting MS, identify subjects with non-MS inflammatory neurological diseases, differentiate healthy subjects from patients with any type of neurological disease, and/or identify subjects with increased disability, CNS tissue damage and/or neurodegeneration. Process-specific biomarkers that can be used in place of a brain biopsy to identify immune cell infiltration and/or activation in the CNS are also described.
    Type: Application
    Filed: February 25, 2019
    Publication date: August 29, 2019
    Applicants: The U.S.A., as represented by the Secretary, Department of Health and Human Services, Montana State University
    Inventors: Bibiana Bielekova, Mika Komori, Peter Kosa, Mark C. Greenwood, Christopher Barbour
  • Patent number: 10307527
    Abstract: Systems, compositions, methods and kits employ protein shells, such as ferritin or viral capsid shells, herein called nanobubbles, to enhance X-ray images of cells or body tissue under certain x-ray imaging methods. The nanobubbles have sub-micron size such as about 10 nm, about 40, 60, or 100 nm and may be functionalized for effective delivery to or uptake by a target tissue, in vivo or a cell culture. The nanobubbles are hollow, having a central core which may be empty or contain a fluid, such that the shells effectively form long-lived bubbles in the imaged environment, and are of low electron density and have different scattering properties than the surrounding tissue. X-ray imaging by spatial frequency heterodyne imaging enhances visualization or detection of tissue regions bearing the shells. The protein shells may be further treated to assure biocompatibility and/or to resist undesired interactions with non-targeted tissue, such as scavenging by the liver, or attack by the immune system.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: June 4, 2019
    Assignees: Brown University, Montana State University
    Inventors: Christoph Rose-Petruck, Trevor Douglas, Danielle Rand, Masaki Uchida
  • Patent number: 10293039
    Abstract: Vaccines and compositions containing an attenuated L. monocytogenes prsA2 htrA deletion mutant for use in the presentation of foreign or exogenous antigens and in the treatment or prevention of diseases such as cancer or infectious disease are provided.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: May 21, 2019
    Assignees: The Board of Trustees of the University of Illinois, Montana State University
    Inventors: Nancy Freitag, Joshua Obar
  • Patent number: 10261098
    Abstract: Biomarkers associated with neuroimmunological disease are described. The disclosed biomarkers are secreted proteins identified in cerebral spinal fluid (CSF) samples of patients with neurological disease. The disclosed biomarkers identify patients with intrathecal inflammation, distinguish multiple sclerosis (MS) patients from patients with other types of inflammatory neurological diseases and from subjects without MS, distinguish progressive MS patients from patients with relapsing-remitting MS, identify subjects with non-MS inflammatory neurological diseases, differentiate healthy subjects from patients with any type of neurological disease, and/or identify subjects with increased disability, CNS tissue damage and/or neurodegeneration. Process-specific biomarkers that can be used in place of a brain biopsy to identify immune cell infiltration and/or activation in the CNS are also described.
    Type: Grant
    Filed: August 17, 2015
    Date of Patent: April 16, 2019
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Montana State University
    Inventors: Bibiana Bielekova, Mika Komori, Peter Kosa, Mark C. Greenwood, Christopher Barbour