Patents Assigned to Mor-Research Application Ltd.
  • Apparatus and method for diagnosing obstructive sleep apnea
    Patent number: 9844336
    Abstract: An embodiment of the invention provides a method of diagnosing obstructive sleep apnea, the method comprising: acquiring a sleep sound signal comprising sounds made by a person during sleep; detecting a plurality of snore sounds in the sleep sound signal; determining a set of mel-frequency cepstral coefficients for each of the snore sounds; determining a characterizing feature for the sleep sound signal responsive to a sum of the variances of the cepstral coefficients; and using the characterizing feature to diagnose obstructive sleep apnea in the person.
    Type: Grant
    Filed: August 24, 2011
    Date of Patent: December 19, 2017
    Assignees: Ben Gurion University of the Negev Research and Development Authority, Mor Research Applications Ltd.
    Inventors: Yaniv Zigel, Ariel Tarasiuk, Nir Ben Israel
  • PROGNOSTIC METHODS AND SYSTEMS OF TREATMENT FOR ACUTE LYMPHOBLASTIC LEUKEMIA
    Publication number: 20170268070
    Abstract: Described herein are methods for determining the prognosis of a patient diagnosed with Acute Lymphoblastic Leukemia (ALL), and particularly determining the risk of disease relapse following standard treatment. Also described are systems of treatment that are directed by a health care provider, and which include the described prognostic methods and the treatments recommended for patients determined to have a specific relapse risk.
    Type: Application
    Filed: July 30, 2015
    Publication date: September 21, 2017
    Applicant: MOR RESEARCH APPLICATIONS LTD.
    Inventors: Smadar AVIGAD, Isaac YANIV, Keren SHICHRUR
  • COMPOSITIONS AND METHODS FOR TREATMENT OF RETINAL DEGENERATIVE DISEASES
    Publication number: 20170266146
    Abstract: This disclosure relates to compositions for use in treatment of Alzheimer's Disease, and/or a ocular and retinal degenerative disease, such as age related macular degeneration. The described compositions include effective amounts of LLMe, the hydrobromide form thereof, or functional derivatives thereof. Methods of treatment of a retinal degenerative disease of Alzheimer's Disease using the described compositions are also provided.
    Type: Application
    Filed: December 3, 2015
    Publication date: September 21, 2017
    Applicant: MOR RESEARCH APPLICATIONS LTD.
    Inventors: Zeev DVASHI, Ayala POLLACK
  • EXTRACELLULAR MATRIX METALLOPROTEINASE INDUCER (EMMPRIN) PEPTIDES AND BINDING ANTIBODIES
    Publication number: 20170247422
    Abstract: Isolated peptides from the protein EMMPRIN (CD147/Basigin) and antibodies directed against antigenic determinants within the peptides. Pharmaceutical compositions including the peptides and antibodies and methods of their production and use in vaccination, immunotherapy and diagnosis of proliferative, hyperpermeability, inflammatory, and angiogenesis-related diseases and disorders.
    Type: Application
    Filed: May 16, 2017
    Publication date: August 31, 2017
    Applicants: MOR - RESEARCH APPLICATIONS LTD., RAPPAPORT FAMILY INSTITUTE FOR RESEARCH IN THE MEDICAL SCIENCES
    Inventors: Michal A. RAHAT, Nitza LAHAT, Miriam WALTER, Haim BITTERMAN
  • Methods and compositions for determining heart failure or a risk of heart failure
    Patent number: 9631236
    Abstract: The present invention is based in part on the discovery of a panel of miRs whose levels are increased or decreased in the circulation of chronic systolic HF patients. Accordingly, an extensive panel of miRs was screened in the sera of stable chronic systolic HF patients and the results were compared to an age, gender and ethnically matched control group.
    Type: Grant
    Filed: May 23, 2012
    Date of Patent: April 25, 2017
    Assignees: Rosetta Genomics Ltd., MOR Research Applications Ltd.
    Inventors: Yaron Goren, Ofer Amir
  • Fertility preservation device
    Patent number: 9532901
    Abstract: The invention relates to ovary apparatus for regulating the temperature of the ovary; and shielding it from radiation. The main function of the device is to preserve fertility of women treated with chemotherapy by lowering the ovary temperature while the toxic medications circulate in the patients' blood. The current invention utilizes shielding of the ovary to protect it from radiation, and temperature decrease to further limit the toxic effect of radiation.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: January 3, 2017
    Assignee: Mor Research Applications Ltd.
    Inventor: Nicola Nasser
  • SOLUBLE CTLA-4 MOLECULES AND DERIVATIVES THEREOF FOR TREATMENT OF MINIMAL CHANGE DISEASE
    Publication number: 20160271218
    Abstract: This disclosure relates to compositions and methods for treatment of minimal change disease. The compositions include soluble CTLA-4 molecules, and derivatives thereof, including belatacept and belatacept-like molecules that have been conjugated to a human immunoglobulin constant domain fragment.
    Type: Application
    Filed: June 26, 2014
    Publication date: September 22, 2016
    Applicant: Mor Research Applications Ltd.
    Inventor: Alexander BIRO
  • Device for placement in the tricuspid annulus
    Patent number: 9445893
    Abstract: A device (200) for implantation in or near an annulus of a tricuspid valve comprising at least one blood flow control element (202) adapted to capture a volume of blood therein. Optionally or alternatively, the blood flow control element is adapted to allow at least some volume of blood (406) to regurgitate through the annulus during at least some part of systole. Optionally or alternatively, the device comprises a relatively rigid annulus with an arc length of less than 300 degrees. Optionally or alternatively, the relatively rigid annulus comprises a plurality of tissue fixation elements positioned along no more than 300 degrees of a circumference of the annulus, for example to avoid damaging conduction pathways between an atria and a chamber.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: September 20, 2016
    Assignee: Mor Research Applications Ltd.
    Inventor: Mordehay Vaturi
  • PROGNOSTIC METHODS, COMPOSITIONS AND KITS FOR PREDICTION OF ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) RELAPSE
    Publication number: 20160222464
    Abstract: The present invention relates to prognostic methods and kits for the assessment and monitoring of relapse-free or disease-free survival of ALL patients. The detection is based on the use of detecting nucleic acids, specific for determination of the expression of at least one of miR-151-5p and miR-451 in a test sample. The invention thereby also provides methods and kits for monitoring and early diagnosis of cancerous disorders associated with low miR-151-5p and/or miR-451 expression, specifically ALL, and appropriate associated treatments thereof.
    Type: Application
    Filed: February 3, 2016
    Publication date: August 4, 2016
    Applicant: Mor Research Applications Ltd.
    Inventors: Smadar Avigad, Isaac Yaniv
  • Method and system for analyzing craniofacial complex images
    Patent number: 9402565
    Abstract: In a method of analysis, a target image is registered to define a plurality of keypoints arranged in sets corresponding to polygons or linear segments in the target image. A database of registered and annotated images is accessed and a polygon-wise comparison between the target image and each database image is employed. The comparison is used for projecting annotated locations from the database images into the target image.
    Type: Grant
    Filed: October 5, 2015
    Date of Patent: August 2, 2016
    Assignees: Mor Research Applications Ltd., Ramot at Tel-Aviv University Ltd.
    Inventors: Yehuda Finkelstein, Lior Wolf
  • TREATMENTS FOR FIBROTIC DISEASES
    Publication number: 20160206591
    Abstract: Disclosed herein are methods for treatment for fibrosis, ocular pathologies associated with fibrosis, including proliferative vitreoretinopathy (PVR) by inhibiting the activity of activated transforming growth factor ? activated kinase 1 (TAK1), or activation thereof. Pharmaceutical compositions for use in the described treatments are also provided.
    Type: Application
    Filed: March 29, 2016
    Publication date: July 21, 2016
    Applicant: MOR RESEARCH APPLICATIONS LTD.
    Inventors: Ayala Pollack, Zeev Dvashi
  • DEVICE FOR PLACEMENT IN THE TRICUSPID ANNULUS
    Publication number: 20160184098
    Abstract: A device (200) for implantation in or near an annulus of a tricuspid valve comprising at least one blood flow control element (202) adapted to capture a volume of blood therein. Optionally or alternatively, the blood flow control element is adapted to allow at least some volume of blood (406) to regurgitate through the annulus during at least some part of systole. Optionally or alternatively, the device comprises a relatively rigid annulus with an arc length of less than 300 degrees. Optionally or alternatively, the relatively rigid annulus comprises a plurality of tissue fixation elements positioned along no more than 300 degrees of a circumference of the annulus, for example to avoid damaging conduction pathways between an atria and a chamber.
    Type: Application
    Filed: March 10, 2016
    Publication date: June 30, 2016
    Applicant: Mor Research Applications Ltd.
    Inventor: Mordehay VATURI
  • COMPOSITIONS AND METHODS FOR TREATMENT OF RETINAL DEGENERATIVE DISEASES
    Publication number: 20160114006
    Abstract: This disclosure relates to compositions for use in treatment of a retinal degenerative disease, such as age related macular degeneration. The described compositions include agents for activating p38 and/or JNK signaling through the activation of TAK1 in the retinal pigment epithelium of a subject diagnosed with the disease. Methods of treatment of a retinal degenerative disease using the described compositions are also provided.
    Type: Application
    Filed: May 29, 2014
    Publication date: April 28, 2016
    Applicant: MOR RESEARCH APPLICATIONS LTD.
    Inventors: Ayala POLLACK, Zeev DVASHI
  • COMPOSITIONS AND METHODS FOR TREATING POST-OPERATIVE COMPLICATIONS OF CARDIOPULMONARY SURGERY
    Publication number: 20160089423
    Abstract: Disclosed herein are compositions and methods for treating damage inflicted by use of a cardio-pulmonary bypass (CPB) machine, particularly excessive bleeding and multi organ failure, by administering a pharmaceutical composition comprising alpha-1 antitrypsin (AAT).
    Type: Application
    Filed: May 12, 2014
    Publication date: March 31, 2016
    Applicant: MOR RESEARCH APPLICATIONS LTD.
    Inventor: Dan Abrahamov
  • METHOD AND SYSTEM FOR ANALYZING CRANIOFACIAL COMPLEX IMAGES
    Publication number: 20160029927
    Abstract: In a method of analysis, a target image is registered to define a plurality of keypoints arranged in sets corresponding to polygons or linear segments in the target image. A database of registered and annotated images is accessed and a polygon-wise comparison between the target image and each database image is employed. The comparison is used for projecting annotated locations from the database images into the target image.
    Type: Application
    Filed: October 5, 2015
    Publication date: February 4, 2016
    Applicants: Ramot at Tel-Aviv University Ltd., Mor Research Applications Ltd.
    Inventors: Yehuda FINKELSTEIN, Lior WOLF
  • Method of treatment of small for gestational age infants under two years of age
    Patent number: 9168289
    Abstract: The invention provides a method and a composition for the treatment of infants age less than 2.5 years old defined as small for gestational age (SGA), including the use of hGH or any compound that increases blood levels of hGH or of IGF-I. Early use of the composition prevents the irreversible neurological and psychological damage of the children.
    Type: Grant
    Filed: January 31, 2012
    Date of Patent: October 27, 2015
    Assignee: MOR RESEARCH APPLICATIONS LTD.
    Inventor: Zvi Laron
  • NUCLEIC ACID DETECTION ASSAY
    Publication number: 20150299805
    Abstract: This invention is directed, inter alia, to methods and kits for rapid, easy and cost-effective methods of breast cancer prediction and diagnosis in inter alia, blood samples.
    Type: Application
    Filed: January 9, 2015
    Publication date: October 22, 2015
    Applicants: BEN GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY, MOR RESEARCH APPLICATIONS LTD.
    Inventor: Amos Douvdevani
  • Method and system for analyzing craniofacial complex images
    Patent number: 9153022
    Abstract: In a method of analysis, a target image is registered to define a plurality of keypoints arranged in sets corresponding to polygons or linear segments in the target image. A database of registered and annotated images is accessed and a polygon-wise comparison between the target image and each database image is employed. The comparison is used for projecting annotated locations from the database images into the target image.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: October 6, 2015
    Assignees: Mor Research Applications Ltd., Ramot at Tel-Aviv University Ltd.
    Inventors: Yehuda Finkelstein, Lior Wolf
  • Apparatus and method for analyzing stream of imaging data
    Patent number: 9147246
    Abstract: A method of analyzing a stream of imaging data is disclosed. The method comprises: for each picture-element of the data, associating a vector of features indicative of temporal intensity variation relative to baseline intensity, thereby providing a plurality of vectors. The method further comprises clustering the picture-elements according to the vectors, thereby providing a plurality of clusters, and identifying different compartments in the vasculature based on the clusters.
    Type: Grant
    Filed: September 1, 2009
    Date of Patent: September 29, 2015
    Assignees: Ben-Gurion University of the Negev Research and Development Authority, Mor Research Applications Ltd.
    Inventors: Alon Friedman, Yoash Chassidim, Ofer Prager, Ilan Shelef
  • Elongated body for deployment in a heart
    Patent number: 9131928
    Abstract: Coronary sinus ring apparatus, including an elongated body for deployment in a coronary sinus, an aperture in a long side of the body, at least a partial lumen extending from one end of the elongated body to at least the aperture, and a guide within the elongated body positioned and shaped to guide an element inserted along the lumen to the aperture. Apparatus for treating a heart, including a delivery tube sized for and adapted for insertion into a body, a sharp tip adapted to be pushed through cardiac muscle, an elongate tensioning element, and a foldable anchor adapted to couple the elongate tension element to cardiac muscle tissue, wherein the delivery tube encloses one or both of the elongate tensioning element and the foldable anchor. Related apparatus is also described.
    Type: Grant
    Filed: December 21, 2009
    Date of Patent: September 15, 2015
    Assignee: Mor Research Applications Ltd.
    Inventors: Amnon Zlotnick, Henry M. Israel, Boaz Harari