Patents Assigned to Morphochem Aktiengesellschaft Fur
  • Oxazolidinone-quinolone hybrid antibacterials for the parenteral treatment or prophylaxis of bacterial diseases
    Patent number: 10723746
    Abstract: The present invention relates to the use of oxazolidinone-quinolone hybrids for the parenteral (especially intravenous) treatment or prophylaxis of bacterial diseases. The present invention relates moreover to improved methods of administering oxazolidinone-quinolone hybrid antibacterials.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: July 28, 2020
    Assignee: Morphochem Aktiengesellschaft Für Kombinatorische Chemie
    Inventors: Thomas Kapsner, Axel Dalhoff, Thomas Gramatte
  • Combination therapy comprising oxazolidinone-quinolones for use in treating bacterial infections
    Patent number: 9993469
    Abstract: The present invention provides a combination of at least one oxazolidinone-quinolone hybrid with at least one further antibacterial compound and the use thereof as drug, especially for the treatment or prophylaxis of bacterial infections.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: June 12, 2018
    Assignee: Morphochem Aktiengesellschaft Für Kombinatorishe Chemie
    Inventors: Thomas Kapsner, Axel Dalhoff
  • OXAZOLIDINONE-QUINOLONE HYBRID ANTIBACTERIALS FOR THE PARENTERAL TREATMENT OR PROPHYLAXIS OF BACTERIAL DISEASES
    Publication number: 20160130288
    Abstract: The present invention relates to the use of oxazolidinone-quinolone hybrids for the parenteral (especially intravenous) treatment or prophylaxis of bacterial diseases. The present invention relates moreover to improved methods of administering oxazolidinone-quinolone hybrid antibacterials.
    Type: Application
    Filed: May 9, 2014
    Publication date: May 12, 2016
    Applicant: MORPHOCHEM AKTIENGESELLSCHAFT FÜR KOMBINATORISCHE CHEMIE
    Inventors: Thomas Kapsner, Axel Dalhoff, Thomas Gramatte
  • Oxazolidinone-quinolone hybrid antibiotics
    Patent number: 9133213
    Abstract: The present invention relates to compounds of the Formula (I) that are useful antimicrobial agents and effective against a variety of multi-drug resistant bacteria:
    Type: Grant
    Filed: July 2, 2013
    Date of Patent: September 15, 2015
    Assignee: Morphochem Aktiengesellschaft Für Kombinatorische Chemie
    Inventors: Christian Hubschwerlen, Jean-Luc Specklin, Daniel Baeschlin, Christine Schmitt, Stefan Müller, Michael W. Cappi
  • Oxazolidinone-quinolone hybrid antibiotics
    Patent number: 8501774
    Abstract: The present invention relates to compounds of the Formula (I) that are useful antimicrobial agents and effective against a variety of multi-drug resistant bacteria:
    Type: Grant
    Filed: February 8, 2012
    Date of Patent: August 6, 2013
    Assignee: Morphochem Aktiengesellschaft für Kombinatorische Chemie
    Inventors: Christian Hubschwerlen, Jean-Luc Specklin, Daniel Baeschlin, Christine Schmitt, Stefan Muller, Michael W. Cappi
  • Dual action antibiotics
    Patent number: 8329908
    Abstract: The present invention relates to compounds of the Formula (I) that are useful antimicrobial agents and effective against a variety of multi-drug resistant bacteria:
    Type: Grant
    Filed: September 10, 2010
    Date of Patent: December 11, 2012
    Assignee: Morphochem Aktiengesellschaft fur Kombinatorische Chemie
    Inventors: Christian Hubschwerlen, Jean-Luc Specklin
  • OXAZOLIDINONE-QUINOLONE HYBRID ANTIBIOTICS
    Publication number: 20120142635
    Abstract: The present invention relates to compounds of the Formula (I) that are useful antimicrobial agents and effective against a variety of multi-drug resistant bacteria:
    Type: Application
    Filed: February 8, 2012
    Publication date: June 7, 2012
    Applicant: Morphochem Aktiengesellschaft Fur Kombinatorische Chemie
    Inventors: Christian Hubschwerlen, Jean-Luc Specklin, Daniel Baeschlin, Christine Schmitt, Stefan Müller, Michael W. Cappi
  • USE OF OXAZOLIDINONE-QUINOLINE HYBRID ANTIBIOTICS FOR THE TREATMENT OF ANTHRAX AND OTHER INFECTIONS
    Publication number: 20120135961
    Abstract: The present invention relates to the use of compounds, in which the pharmacophores of quinolone and oxazolidinone are chemically linked together through a linker that is stable under physiological conditions, for the treatment of anthrax and other infections.
    Type: Application
    Filed: January 10, 2011
    Publication date: May 31, 2012
    Applicant: Morphochem Aktiengesellschaft Fur Kombinatorische Chemie
    Inventors: Christian Hubschwerlen, Jean-Luc Specklin, Daniel Baeschlin, Hans Locher, Christine Schmitt
  • Oxazolidinone-quinolone hybrid antibiotics
    Patent number: 8158797
    Abstract: The present invention relates to compounds of the Formula (I) that are useful antimicrobial agents and effective against a variety of multi-drug resistant bacteria.
    Type: Grant
    Filed: December 20, 2004
    Date of Patent: April 17, 2012
    Assignee: Morphochem Aktiengesellschaft fur Kombinatorische Chemie
    Inventors: Christian Hubschwerlen, Jean-Luc Specklin, Daniel Baeschlin, Christine Schmitt, Stefan Müller, Michael W. Cappi
  • Intermediate products for producing oxazolidinone-quinolone hybrids
    Patent number: 8124772
    Abstract: The present invention describes intermediates (ZP) for a novel and efficient synthesis of compounds in which the pharmacophores of quinolone and oxazolidinone are linked to one another by way of a chemically stable linker.
    Type: Grant
    Filed: June 5, 2009
    Date of Patent: February 28, 2012
    Assignee: Morphochem Aktiengesellschaft für Kombinatorische Chemie
    Inventors: Christian Hubschwerlen, Jean-Luc Specklin, Jean Phillippe Surivet, Daniel Baeschlin
  • 5-Quinoline derivatives having an anti-bacterial activity
    Publication number: 20100324030
    Abstract: The present invention describes novel anti-bacterial compounds of the formula (I). These compounds are, amongst others, of interest as inhibitors of DNA gyrase and topoisomerases, for example of topoisomerase II and IV.
    Type: Application
    Filed: April 11, 2008
    Publication date: December 23, 2010
    Applicant: Morphochem Aktiengesellschaft Fur Kombinatorische Chemie
    Inventors: Glenn Dale, Sabine Pierau, Michael W. Cappi, Christopher Gray, Christian Hubschwerlen, Jean P. Surivet, Cornelia Zumbrunn
  • Dual action antibiotics
    Patent number: 7820823
    Abstract: The present invention relates to compounds of the Formula (I) that are useful antimicrobial agents and effective against a variety of multi-drug resistant bacteria.
    Type: Grant
    Filed: October 4, 2002
    Date of Patent: October 26, 2010
    Assignee: Morphochem Aktiengesellschaft Fur Kominatorische Chemi
    Inventors: Christian Hubschwerlen, Jean-Luc Specklin
  • Thia-epothilone derivatives for the treatment of cancer
    Patent number: 7645782
    Abstract: The present invention relates to new Macrocycles of formula (I) and their use for the treatment of cancer.
    Type: Grant
    Filed: November 28, 2003
    Date of Patent: January 12, 2010
    Assignees: Morphochem Aktiengesellschaft fur Kombinatorische Chemie
    Inventors: Wolfgang Richter, Lutz Weber
  • Intermediate products for producing oxazolidinone-quinolone hybrids
    Publication number: 20090306389
    Abstract: The present invention describes intermediates (ZP) for a novel and efficient synthesis of compounds in which the pharmacophores of quinolone and oxazolidinone are linked to one another by way of a chemically stable linker.
    Type: Application
    Filed: June 5, 2009
    Publication date: December 10, 2009
    Applicant: Morphochem Aktiengesellschaft fur Kombinatorische Chemie
    Inventors: Christian Hubschwerlen, Jean-Luc Specklin, Jean Phillippe Surivet, Daniel Baeschlin
  • Intermediate products for producing oxazolidinone-quinolone hybrids
    Patent number: 7557214
    Abstract: The present invention describes intermediates (ZP) for a novel and efficient synthesis of compounds in which the pharmacophores of quinolone and oxazolidinone are linked to one another by way of a chemically stable linker.
    Type: Grant
    Filed: September 3, 2004
    Date of Patent: July 7, 2009
    Assignee: Morphochem Aktiengesellschaft für Kombinatorische Chemie
    Inventors: Christian Hubschwerlen, Jean-Luc Specklin, Jean Phillippe Surivet, Daniel Baeschlin
  • Novel Compounds That Inhibit Factor Xa Activity
    Publication number: 20080051388
    Abstract: The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts, solvates, hydrates or pharmaceutically acceptable formulations thereof. Those compounds can be used in inhibiting factor Xa and in the prevention and/or treatment of thrombolytic conditions.
    Type: Application
    Filed: July 19, 2005
    Publication date: February 28, 2008
    Applicant: Morphochem Aktiengesellschaft Fur Kombinatorische Chemie
    Inventors: Thilo Fuchs, Robert Eckl
  • Oxazolidinone-Quinolone Hybrid Antibiotics
    Publication number: 20080027040
    Abstract: The present invention relates to compounds of the Formula (I) that are useful antimicrobial agents and effective against a variety of multi-drug resistant bacteria:
    Type: Application
    Filed: December 20, 2004
    Publication date: January 31, 2008
    Applicant: Morphochem Aktiengesellschaft Fur Kombinatorische
    Inventors: Christian Hubschwerlen, Jean-Luc Specklin, Daniel Baeschlin, Christine Schmitt, Stefan Muller, Michael W. Cappi
  • Novel Compounds Having an Anti-Bacterial Activity
    Publication number: 20070244103
    Abstract: The present invention describes novel anti-bacterial compounds of formula (I). Q-A-R3??(I) These compounds are, amongst others, of interest as inhibitors of DNA gyrase.
    Type: Application
    Filed: August 25, 2005
    Publication date: October 18, 2007
    Applicant: Morphochem Aktiengesellschaft Fur Kombinatorische Chemie
    Inventors: Sabine Pierau, Glenn Dale, Michael Cappi, Cornelia Zumbrunn, Christian Hubschwerlen, Jean Surivet
  • Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections
    Publication number: 20070155714
    Abstract: The present invention relates to the use of compounds, in which the pharmacophores of quinolone and oxazolidinone are chemically linked together through a linker that is stable under physiological conditions, for the treatment of anthrax and other infections.
    Type: Application
    Filed: April 6, 2004
    Publication date: July 5, 2007
    Applicant: Morphochem Aktiengesellschaft Fur Kombinatorische Chemie
    Inventors: Christian Hubschwerlen, Jean-Luc Specklin, Daniel Baeschlin, Hans Locher, Christine Schmitt
  • Novel compounds having an antibacterial activity
    Publication number: 20060205719
    Abstract: The present invention describes novel anti-bacterial compounds of formula (I). These compounds are, amongst others, of interest as inhibitors of Topoisomerase IV (Topo IV) as well as of DNA gyrase.
    Type: Application
    Filed: March 29, 2004
    Publication date: September 14, 2006
    Applicant: Morphochem Aktiengesellschaft Fur
    Inventors: Christian Hubschwerlen, Jean Surivet, Cornelia Zumbrunn