Abstract: The present invention discloses novel screening strategies for the identification of binders that target the active site of enzymatic antigens. The present invention also discloses antigen-binding moieties which bind to the NS2B-NS3 Proteinase of West Nile Virus, in particular binders which bind to the active site, thereby inhibiting the enzymatic activity of the proteinase. The antigen-binding moieties of the present invention have numerous therapeutic and diagnostic applications.
Type:
Grant
Filed:
August 6, 2010
Date of Patent:
September 15, 2015
Assignee:
MorphoSys A6
Inventors:
Christian Frisch, Achim Knappik, Alex Y. Strongin, Sergey A. Shiryaev