Abstract: The present invention relates to an improved method for peak fractionation and eluate collection during chromatography for purification of a human therapeutic antibody.
Type:
Grant
Filed:
November 20, 2020
Date of Patent:
October 13, 2026
Assignee:
MorphoSys GmbH
Inventors:
Daniela Daubert, Dominik Geltinger, Karin Felderer
Abstract: The present invention provides antibodies and fragments thereof that specifically detect the complex of a specific cognate antigen-binding moiety, in particular antibodies, and its antigen. The antibodies of the present disclosure do not bind either said cognate antigen binding moiety or said antigen alone and this can be used e.g. to directly detect antigen-bound antigen-binding moieties. Further disclosed are methods for production and use of said antibodies and antibody fragments.
Type:
Grant
Filed:
March 30, 2023
Date of Patent:
March 31, 2026
Assignee:
MORPHOSYS GMBH
Inventors:
Stefan Haertle, Christian Frisch, Achim Knappik