Patents Assigned to Morphotek
  • Methods for generating hypermutable yeast
    Patent number: 6921666
    Abstract: Yeast cells are mutagenized to obtain desirable mutants. Mutagenesis is mediated by a defective mismatch repair system which can be enhanced using conventional exogenously applied mutagens. Yeast cells with the defective mismatch repair system are hypermutable, but after selection of desired mutant yeast strains, they can be rendered genetically stable by restoring the mismatch repair system to proper functionality.
    Type: Grant
    Filed: August 15, 2003
    Date of Patent: July 26, 2005
    Assignees: The Johns Hopkins University, Morphotek
    Inventors: Nicholas C. Nicolaides, Philip M. Sass, Luigi Grasso, Bert Vogelstein, Kenneth W. Kinzler