Abstract: A composition for improving memory and concentration in mammals with disorders associated with memory impairment. The composition comprises a combination of at least one phytoestrogen and at least one acetylcholinesterase inhibitor such as Huperzine A, or any derivative, analog, metabolite or combination thereof. The composition may further include at least one mammalian estrogen. The method of the invention comprises the co-administration of at least one phytoestrogen and at least one acetylcholinesterase inhibitor in a therapeutically effective amount. Additionally, a mammalian estrogen may be co-administered.
Type:
Grant
Filed:
June 23, 2000
Date of Patent:
February 25, 2003
Assignees:
Wake Forest University Health Services, Morris Notelovitz
Inventors:
Morris Notelivitz, Thomas B. Clarkson, Yuanlong Pan, Mary S. Anthony