Abstract: The invention provides inter alia a method for differentiating an adipogenic progenitor cell. comprising the step of:—culturing an adipogenic progenitor cell in a serum-free medium for differentiating an adipogenic progenitor cell. wherein the serum-free medium comprises:—at least one peroxisome proliferator-activated receptor gamma (PPARy) agonist:—at least one hormone selected from the group consisting of insulin and hydrocortisone:—at least one cytokine and/or growth factor selected from the group consisting of bone morphogenetic protein 4 (BMP4) and epidermal growth factor (EGF); and-ascorbic acid or a derivative thereof.

Abstract: Disclosed is an apparatus for the production of tissue from cells. The apparatus comprises an elongate body having at least one circumferential groove and being operable to extend, by close-fitting relationship, centrally through at least one trough. The troughs are extending in a closed path, such that the at least one of the circumferential grooves open into an inner edge of a trough. Also disclosed is a process for production of tissue from cells, via a transitioning intermediate which transitions from the cells into the tissue.