Abstract: A universal gel and methods of use in detecting the presence, or absence, of one or more target molecules in a test sample comprising the formation of a universal gel hybridization complex, wherein an adapter molecule is hybridized to a target molecule and universal capture probe is disclosed.
Type:
Application
Filed:
October 1, 2001
Publication date:
December 26, 2002
Applicant:
Mosaic Technologies, Inc.
Inventors:
Lawrence Weir, T. Christian Boles, Ezra S. Arams
Abstract: This invention features methods and apparatus for performing nucleic acid hybridization and amplification processes on a support. Such methods and apparatus are useful for synthesizing nucleic acid and detecting target nucleic acid for diagnostics and therapeutics.
Type:
Grant
Filed:
June 9, 2000
Date of Patent:
October 22, 2002
Assignees:
Mosaic Technologies, Inc., Whitehead Institute for Biomedical Research
Abstract: A multi-stage bridge amplification method which uses a recovered single-stranded amplification single-stranded nucleic acid molecule to initiate second and subsequent stages of bridge amplification is described.
Abstract: This invention features methods, apparatus and kits for performing nucleic acid hybridization and amplification reactions on a support. Such methods and apparatus are useful in diagnostic and therapeutic processes for synthesizing nucleic acid and detecting target nucleic acids in a sample.
Type:
Application
Filed:
October 2, 2001
Publication date:
May 23, 2002
Applicant:
Mosaic Technologies, Inc.
Inventors:
Christopher P. Adams, Truett C. Boles, Andrew R. Muir, Stephen J. Kron
Abstract: A multi-stage bridge amplification method which uses a recovered single-stranded amplification single-stranded nucleic acid molecule to initiate second and subsequent stages of bridge amplification is described.
Abstract: Devices and methods for detecting the presence, or absence of the presence of at least one target molecule employing a receptacle housing a reaction chamber comprised of at least one compartment containing suitable reagents for the detection of the target molecule are disclosed.
Type:
Grant
Filed:
November 25, 1998
Date of Patent:
June 26, 2001
Assignee:
Mosaic Technologies, Inc.
Inventors:
Andrew R. Muir, T. Christian Boles, Christopher P. Adams
Abstract: Disclosed is a polymerizable complex containing a covalently attached nucleic acid molecule which, under appropriate conditions, is capable of copolymerization with a second polymerizable ethylene-containing monomer unit to form a polymerized layer. The polymerized layer containing attached nucleic acid is useful in a variety of contexts including, for example, hybridization assays. The polymerized layer containing the covalently attached nucleic acid molecule can be formed into a variety of shapes, or attached to a formed material through appropriate chemistry.
Type:
Grant
Filed:
October 30, 1998
Date of Patent:
January 30, 2001
Assignee:
Mosaic Technologies, Inc.
Inventors:
T. Christian Boles, Stephen J. Kron, Christopher P. Adams
Abstract: This invention features methods and apparatus for performing nucleic acid hybridization and amplification processes on a support. Such methods and apparatus are useful for synthesizing nucleic acid and detecting target nucleic acid for diagnostics and therapeutics.
Type:
Grant
Filed:
May 29, 1997
Date of Patent:
July 18, 2000
Assignees:
Mosaic Technologies, Inc., Whitehead Institute for Biomedical Research
Abstract: Disclosed is a polymerizable complex containing a covalently attached nucleic acid molecule which, under appropriate conditions, is capable of copolymerization with a second polymerizable ethylene-containing monomer unit to form a polymerized layer. The polymerized layer containing attached nucleic acid is useful in a variety of contexts including, for example, hybridization assays. The polymerized layer containing the covalently attached nucleic acid molecule can be formed into a variety of shapes, or attached to a formed material through appropriate chemistry.
Type:
Grant
Filed:
March 5, 1997
Date of Patent:
August 3, 1999
Assignee:
Mosaic Technologies, Inc.
Inventors:
T. Christian Boles, Stephen J. Kron, Christopher P. Adams
Abstract: This invention features methods and apparatus for performing nucleic acid hybridization and amplification processes on a support. Such methods and apparatus are useful for synthesizing nucleic acid and detecting target nucleic acid for diagnostics and therapeutics.
Type:
Grant
Filed:
August 3, 1994
Date of Patent:
June 24, 1997
Assignees:
Mosaic Technologies, Inc., Whitehead Institute for Biomedical Research
Inventors:
Christopher P. Adams, Stephen Joseph Kron