Abstract: The invention is directed to a method for inhibiting angiogenesis and thus treating inflammatory diseases (e.g., rheumatoid arthritis, diabetic retinopathy, psoriasis, and macular degeneration), inhibiting and preventing tumor growth and preventing metastases in a mammal comprising administering to the mammal an effective amount of a monoclonal antibody which is an antagonist of the integrins, GPIIb/IIIa (&agr;IIb&bgr;3) and &agr;v&bgr;3.
Type:
Application
Filed:
May 15, 2001
Publication date:
April 18, 2002
Applicant:
MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY, CENTOCOR INC.
Inventors:
Barry Coller, Robert Jordan, Judith Varner