Abstract: System and method for facilitating user thinking about an arbitrary problem with improved search capabilities. Some embodiments provide improved search capabilities through the application of archetypes for problem solving and other factors at a number of points throughout the total search process.

Abstract: Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and methods for using these devices and systems for performing a wide variety of fluid operations are provided. The devices and systems of are used in performing fluid operations which require a large number of iterative, successive or parallel fluid manipulations, in a microscale, or sealed and readily automated format.