Patents Assigned to Mountain View
-
Patent number: 9125880Abstract: Methods are provided for the synthesis of polymer conjugates of cytokines and receptor-binding antagonists thereof, especially a non-glycosylated interferon-beta, which conjugates retain unusually high biological potency. Preparation of polymer conjugates according to the methods of the present invention diminishes or avoids steric inhibition of receptor-ligand interactions that commonly results from the attachment of polymers to receptor-binding regions of cytokines, as well as to agonistic and antagonistic analogs thereof. The invention also provides conjugates and compositions produced by such methods. The conjugates of the present invention retain a high level of biological potency compared to those produced by traditional polymer coupling methods that are not targeted to avoid receptor-binding domains of cytokines.Type: GrantFiled: December 23, 2003Date of Patent: September 8, 2015Assignee: Mountain View Pharmaceuticals, Inc.Inventors: Mark G. P. Saifer, Alexa L. Martinez, L. David Williams, Merry R. Sherman
-
Patent number: 8921064Abstract: A naturally occurring or recombinant protein, especially a mutein of porcine urate oxidase (uricase), that is essentially free of large aggregates can be rendered substantially non-immunogenic by conjugation with a sufficiently small number of strands of polymer such that the bioactivity of the protein is essentially retained in the conjugate. Such conjugates are unusually well suited for treatment of chronic conditions because they are less likely to induce the formation of antibodies and/or accelerated clearance than are similar conjugates prepared from protein preparations containing traces of large aggregates.Type: GrantFiled: April 13, 2011Date of Patent: December 30, 2014Assignees: Mountain View Pharmaceuticals, Inc., Duke UniversityInventors: Merry R. Sherman, Mark G. P. Saifer, L. David Williams, Michael S. Hershfield, Susan J. Kelly
-
Publication number: 20140363414Abstract: A naturally occurring or recombinant protein, especially a mutein of porcine urate oxidase (uricase), that is essentially free of large aggregates can be rendered substantially non-immunogenic by conjugation with a sufficiently small number of strands of polymer such that the bioactivity of the protein is essentially retained in the conjugate. Such conjugates are unusually well suited for treatment of chronic conditions because they are less likely to induce the formation of antibodies and/or accelerated clearance than are similar conjugates prepared from protein preparations containing traces of large aggregates.Type: ApplicationFiled: August 18, 2014Publication date: December 11, 2014Applicants: Mountain View Pharmaceuticals, Inc., Duke UniversityInventors: Merry R. SHERMAN, Mark G.P. Saifer, L. David Williams, Michael S. Hershfield, Susan J. Kelly
-
Patent number: 8851535Abstract: A security device for a double door, including a first locking portion having a curved portion and an elongated male portion, and a second locking portion having a curved portion and an elongated female portion. A lock mechanism includes a pair of rows of teeth having a gap therebetween and associated with the bottom side of the male portion and a locking prong mounted to the female portion. The locking prong has a flexible finger portion that terminates in a T-shaped end. The finger portion can slide between the gap in the rows of teeth. A release button mounted on the female portion, when pressed, causes the locking prong to bend downward, disengaging the T-shaped end from between the teeth and allowing the first and second locking portions to separate, thereby unlocking the security device.Type: GrantFiled: March 15, 2012Date of Patent: October 7, 2014Assignee: Mountain View Promotions, Inc.Inventors: Hugh Michael Miskel, John Tyler Willis Hagler, Patrick Brian Murphy
-
Patent number: 8618267Abstract: A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.Type: GrantFiled: April 8, 2011Date of Patent: December 31, 2013Assignees: Mountain View Pharmaceuticals, Inc., Duke UniversityInventors: L. David Williams, Michael S. Hershfield, Susan J. Kelly, Mark G. P. Saifer, Merry R. Sherman
-
Publication number: 20120235427Abstract: A security device for a double door, including a first locking portion having a curved portion and an elongated male portion, and a second locking portion having a curved portion and an elongated female portion. A lock mechanism includes a pair of rows of teeth having a gap therebetween and associated with the bottom side of the male portion and a locking prong mounted to the female portion. The locking prong has a flexible finger portion that terminates in a T-shaped end. The finger portion can slide between the gap in the rows of teeth. A release button mounted on the female portion, when pressed, causes the locking prong to bend downward, disengaging the T-shaped end from between the teeth and allowing the first and second locking portions to separate, thereby unlocking the security device.Type: ApplicationFiled: March 15, 2012Publication date: September 20, 2012Applicant: MOUNTAIN VIEW PROMOTIONS, INC.Inventors: Hugh Michael Miskel, John Tyler Willis Hagler, Patrick Brian Murphy
-
Publication number: 20120149083Abstract: A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.Type: ApplicationFiled: November 29, 2011Publication date: June 14, 2012Applicants: Duke University, Mountain View Pharmaceuticals, Inc.Inventors: L. David Williams, Michael S. Hershfield, Susan J. Kelly, Mark G.P. Saifer, Merry R. Sherman
-
Publication number: 20120124951Abstract: A duct screen mountable in an air duct for retaining objects which pass through an associated register, the screen having a filtering base having a plurality of holes and a frame to hold the filtering base in place within the air duct.Type: ApplicationFiled: November 18, 2011Publication date: May 24, 2012Applicant: MOUNTAIN VIEW PROMOTIONS, INC.Inventor: Hugh Michael Miskel
-
Publication number: 20120114742Abstract: Methods are provided for the preparation of conjugates of a variety of bioactive components, especially proteins, with water-soluble polymers (e.g., poly(ethylene glycol) and derivatives thereof), which conjugates have reduced antigenicity and immunogenicity compared to similar conjugates prepared using poly(ethylene glycol) containing a methoxyl or another alkoxyl group. The invention also provides conjugates prepared by such methods, compositions comprising such conjugates, kits containing such conjugates or compositions and methods of use of the conjugates and compositions in diagnostic and therapeutic protocols.Type: ApplicationFiled: January 13, 2012Publication date: May 10, 2012Applicant: Mountain View Pharmaceuticals, Inc.Inventors: Alexa L. MARTINEZ, Merry R. Sherman, Mark G.P. Saifer, L. David Williams
-
Patent number: 8129330Abstract: Methods are provided for the preparation of conjugates of a variety of bioactive components, especially proteins, with water-soluble polymers (e.g., poly(ethylene glycol) and derivatives thereof), which conjugates have reduced antigenicity and immunogenicity compared to similar conjugates prepared using poly(ethylene glycol) containing a methoxyl or another alkoxyl group. The invention also provides conjugates prepared by such methods, compositions comprising such conjugates, kits containing such conjugates or compositions and methods of use of the conjugates and compositions in diagnostic and therapeutic protocols.Type: GrantFiled: September 25, 2003Date of Patent: March 6, 2012Assignee: Mountain View Pharmaceuticals, Inc.Inventors: Alexa L Martinez, Merry R Sherman, Mark G. P. Saifer, L. David Williams
-
Patent number: 8067553Abstract: A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.Type: GrantFiled: April 28, 2010Date of Patent: November 29, 2011Assignees: Mountain View Pharmaceuticals, Inc., Duke UniversityInventors: L. David Williams, Michael S. Hershfield, Susan J. Kelly, Mark G. P. Saifer, Merry R. Sherman
-
Patent number: 7968681Abstract: Polypeptides comprising monomer domains that bind to c-MET, or portions thereof, are provided.Type: GrantFiled: April 15, 2010Date of Patent: June 28, 2011Assignee: Amgen Mountain View, Inc.Inventors: Willem P. C. Stemmer, D. Victor Perlroth, Sanjeev Satyal, Benjamin M. Alba, Alice Bakker, Amy N. Duguay, Qiang Lui, Joshua Silverman, Richard Smith, Candace Swimmer
-
Patent number: 7962433Abstract: System and method for facilitating user thinking about an arbitrary problem with improved search capabilities. Some embodiments provide improved search capabilities through the application of archetypes for problem solving and other factors at a number of points throughout the total search process.Type: GrantFiled: November 13, 2007Date of Patent: June 14, 2011Assignee: Mountain ViewInventors: James Ralph Heidenreich, Linda Shawn Higgins
-
Patent number: 7927589Abstract: A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.Type: GrantFiled: August 3, 2007Date of Patent: April 19, 2011Assignee: Mountain View Pharmaceuticals, Inc.Inventors: L. David Williams, Michael S. Hershfield, Susan J. Kelly, Mark G. P. Saifer, Merry R. Sherman
-
Patent number: 7927852Abstract: A naturally occurring or recombinant protein, especially a mutein of porcine urate oxidase (uricase), that is essentially free of large aggregates can be rendered substantially non-immunogenic by conjugation with a sufficiently small number of strands of polymer such that the bioactivity of the protein is essentially retained in the conjugate. Such conjugates are unusually well suited for treatment of chronic conditions because they are less likely to induce the formation of antibodies and/or accelerated clearance than are similar conjugates prepared from protein preparations containing traces of large aggregates.Type: GrantFiled: August 3, 2007Date of Patent: April 19, 2011Assignee: Mountain View Pharmaceuticals, Inc.Inventors: Merry R. Sherman, Mark G. P. Saifer, L. David Williams, Michael S. Hershfield, Susan J. Kelly
-
Publication number: 20100292167Abstract: Polypeptides comprising monomer domains that bind to c-MET, or portions thereof, are provided.Type: ApplicationFiled: April 15, 2010Publication date: November 18, 2010Applicant: AMGEN MOUNTAIN VIEW, INC.Inventors: WILLEM P.C. STEMMER, D. Victor PERLROTH, SANJEEV SATYAL, BENJAMIN M. ALBA, ALICE BAKKER, AMY N. DUGUAY, QIANG LIU, JOSHUA SILVERMAN, RICHARD SMITH, CANDACE SWIMMER
-
Patent number: 7820790Abstract: Polypeptides comprising monomer domains that bind to IL-6, or portions thereof, are provided.Type: GrantFiled: January 18, 2007Date of Patent: October 26, 2010Assignee: Amgen Mountain View Inc.Inventors: Alice Bakker, Amy N. Duguay, Qiang Liu, Joshua Silverman, Kevin Moore
-
Patent number: 7803907Abstract: Polypeptides comprising monomer domains that bind to c-MET, or portions thereof, are provided.Type: GrantFiled: June 17, 2005Date of Patent: September 28, 2010Assignee: Amgen Mountain View, Inc.Inventors: Willem P. C. Stemmer, D. Victor Perlroth, Sanjeev Satyal, Benjamin M. Alba, Alice Bakker, Amy N. Duguay, Qiang Liu, Joshua Silverman, Richard Smith, Candace Swimmer
-
Patent number: 7786262Abstract: Polypeptides comprising monomer domains that bind to IL-6, or portions thereof, are provided.Type: GrantFiled: July 12, 2006Date of Patent: August 31, 2010Assignee: Amgen Mountain View Inc.Inventors: Alice Bakker, Amy N. Duguay, Qiang Liu, Joshua Silverman, Kevin Moore
-
Patent number: D825049Type: GrantFiled: December 16, 2016Date of Patent: August 7, 2018Assignee: MOUNTAIN VIEW PROMOTIONS, INC.Inventor: Hugh Michael Miskel