Abstract: Systems, devices, and methods are provided for measuring fluid flow across a pump used in a system for precisely and accurately metering fluid. The systems, devices, and methods can use contactless approaches to measure the properties of the fluid being pumped. The measured properties can be used to precisely and accurately determine the flow rate through the pump.

Abstract: The disclosure relates to systems and methods for controlling the sodium and bicarbonate concentrations in a dialysate. The systems and methods can use conductivity sensors to control the addition of water and bicarbonate to accurately control the final concentrations of both sodium and bicarbonate.

Abstract: In some examples, a medical system including a stent configured to be positioned within a ureter of a patient. The stent includes one or more distal petals and/or one or more proximal petals resiliently biased to deploy radially outwards from a stent body. The stent may be configured to position the distal petals in a kidney of a patient and position the proximal petals in a bladder of the patient. The distal petals and/or proximal petals may be configured to resist a migration of the stent within the ureter. The stent may include suture configured to cause the distal petals and/or proximal petals to substantially to collapse for withdrawal of the stent. The medical system may include a sheath to retain the distal petals and/or proximal petals in a collapsed condition during, for example, implantation in the patient.

Abstract: The invention relates to systems and methods for making intracycle adjustments to an osmotic agent concentration of peritoneal dialysate inside the peritoneal cavity of a patient. The systems and methods include osmotic agent sources, flow paths, and processors to adjust the osmotic agent concentration of dialysate in the peritoneal cavity of the patient. The method can include infusing peritoneal dialysate containing an osmotic agent into the peritoneal cavity of a patient; monitoring one or more patient parameters; and adjusting the osmotic agent concentration of the peritoneal dialysate in the peritoneal cavity of the patient by infusing a concentrated osmotic agent solution or by infusing sterile fluid into the peritoneal cavity of the patient using an on-line peritoneal dialysis machine. The system can include a peritoneal dialysis cycler.

Abstract: The invention relates to systems and methods for disinfecting, recharging, and conditioning zirconium phosphate in a reusable sorbent module. The systems and methods provide for reuse of a zirconium phosphate sorbent module after dialysis.

Abstract: The disclosure relates to systems and methods for generating a brine solution using a canister for recharging zirconium phosphate in a reusable sorbent module. The canister can include salt and have an inlet and an outlet. The inlet can extend upwardly into an interior of the canister above solid sodium chloride and sodium acetate. Water can be added to dissolve the salts in the canister and the resulting solution can be collected as a brine solution for use in recharging the zirconium phosphate.

Abstract: A blood based solute monitoring system for measuring at least one blood solute species that has a first recirculation flow path in communication with a dialyzer. The first recirculation flow path is configured to allow a fluid to recirculate through a dialyzer such that the concentration of at least one solute species in the fluid becomes equilibrated to the solute species concentration of the blood compartment of the dialyzer. The blood solute monitoring system has at least one sensor to measure a fluid characteristic.

Abstract: Systems, devices, and methods are provided for sensing gas bubbles within a liquid flow line, such as within a medical device. The systems, devices, and methods can measure a change in capacitance across a pair of conductive plates to calculate a volume of gas in a flow line. If a calculated volume of gas exceeds an established threshold, an alert can be sent and/or changes made to operation of the device.

Abstract: The invention relates to devices, systems, and methods for performing a precision or personalized Peritoneal Dialysis (PD) therapy session or cycle based on dialysis adequacy measurements in patients undergoing peritoneal dialysis treatment. The settings for the precision peritoneal dialysis therapy session can be obtained using one or more flow sensors and one or more uremic solute sensors that measure the uremic solute concentration and volume of the peritoneal dialysate removed from the patient. The desired dialysis adequacy for a specific patient, group of patients, or class of patients, can then be calculated based on the measured peritoneal dialysate concentration and volume. Using the calculated dialysis adequacy, the system and methods can then set one or more peritoneal dialysis parameters for subsequent cycles or sessions.

Abstract: The invention relates to devices, systems, and methods for measuring dialysis adequacy in patients undergoing peritoneal dialysis treatment. The devices, systems, and methods use one or more flow sensors and one or more solute sensors to measure the concentration of a uremic solute and volume of the peritoneal dialysate removed from the patient, and to calculate the dialysis adequacy based on the measured peritoneal dialysate concentration and volume.

Abstract: Systems and methods for generating a brine solution using a salt bag for recharging zirconium phosphate in a reusable sorbent module are provided. The salt bag can be a double layer bag. An inner water permeable bag can contain solid salts and can be surrounded by an outer water impermeable bag. Water can be added to dissolve the salts in the inner bag and the resulting solution can be collected as a brine solution for use in recharging the zirconium phosphate.

Abstract: A portable dialysis cabinet for use in dialysis. The portable dialysis cabinet can have a size and weight that facilitates easy movement of the cabinet from one location to another with relative ease. The portable dialysis cabinet can have additional features necessary to facilitate portability, such as wheels and a handle. In general, the portable dialysis cabinet can contain all the necessary components for performing a dialysis session.

Abstract: Systems and methods for generating a brine solution using a canister for recharging zirconium phosphate in a reusable sorbent module are provided. The canister can include salt and have an inlet and an outlet. The inlet can extend upwardly into an interior of the canister above solid sodium chloride and sodium acetate. Water can be added to dissolve the salts in the canister and the resulting solution can be collected as a brine solution for use in recharging the zirconium phosphate.

Abstract: A container system configured to transfer heat to a fluid contained within the container system, such as dialysate. The container system may be configured to fluidly couple to a medical machine. The container system includes a flexible material comprising a wall of the container system. In examples, the flexible material defines a container volume configured to contain the fluid. The flexible material mechanically supports a circuit configured to generate and transfer heat to the fluid. The circuit is configured to flex and/or bend when the flexible material flexes and/or bends. In examples, the container system includes control circuitry configured to cause the circuit to generate heat based on a temperature of the fluid.

Abstract: Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patient parameters. By comparing the patient's past responses to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session.

Abstract: A single or multiple lumen catheter is disclosed which includes an expandable lumen. The expandable lumen is movable from a collapsed or sealed configuration to an open or expanded configuration. In the open configuration, the expandable lumen is dimensioned to receive a guidewire or stylet or facilitate the introduction of fluids into a patient.

Abstract: A stylet includes an elongate body defining a passage and at least one aperture in fluid communication with the passage. The stylet also includes a first blocking dam secured to the elongate body proximal to the at least one aperture and a second blocking dam secured to the elongate body distal to the at least one aperture. The stylet is movable within a lumen of a catheter to a position in which the first and second blocking dams are, respectively, proximal and distal to at least one side opening of the catheter and each of the first and second blocking dams is sealingly engaged with an inner surface of the catheter such that fluid introduced into the lumen, from the passage and through the at least one aperture of the stylet, is directed through the at least one side opening of the catheter.

Abstract: A venous air capture chamber for use in dialysis, includes an upwardly extending fluid inlet terminating in first and second fluid inlet ports (102). The first and second fluid inlet ports (102) are opposedly positioned on the fluid inlet at an angle of about 180°. The venous air capture chamber also includes a fluid outlet (104) at the bottom of the chamber body. The venous air capture chamber provides improved fluid dynamics, reducing both stagnant flow and turbulence. The venous air capture chamber also provides for bidirectional flow of fluid through the chamber.

Abstract: The invention relates to a testing system and related methods for detecting peritonitis or infection in peritoneal dialysate removed from a patient. The testing system can include a fluid sensor apparatus in a fluid line of a peritoneal dialysis cycler through which spent peritoneal dialysate can be pumped. The fluid sensor apparatus can detect one or more markers associated with peritonitis or infection.

Abstract: A stacked sorbent assembly for use in sorbent dialysis. The stacked sorbent assembly contains two or more interchangeable sorbent pouches that allow for fluid to freely pass into and through the sorbent materials, while keeping the sorbent materials inside the sorbent pouches. Any of the pouches in the sorbent cartridge can be reused and/or recharged.