Abstract: A variable-trim frame for two-wheeled vehicles has a fork able to connect a handlebar to a hub of a front wheel of the vehicle. A regulating element is provided to rotatably couple the lower portion of the shaft of the handlebar with respective portions of the blades of the fork and destined to make the fork assume a predetermined position in which it is inclined by a relative angle with respect to a perpendicular plane to the ground. A blocking device stabilizes the fork in the predetermined position.