Abstract: Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.
Type:
Application
Filed:
October 22, 2009
Publication date:
February 18, 2010
Applicant:
MPEX PHARMACEUTICALS, INC.
Inventors:
Mark W. Surber, Keith A. Bostian, Michael N. Dudley, Olga Lomovskaya, David C. Griffith
Abstract: Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.
Type:
Application
Filed:
October 22, 2009
Publication date:
February 18, 2010
Applicant:
MPEX PHARMACEUTICALS, INC.
Inventors:
Mark W. Surber, Keith A. Bostian, Michael N. Dudley, Olga Lomovskaya (AKA Olga Rodny), David C. Griffith
Abstract: Disclosed are compounds having polybasic functionalities. The compounds inhibit bacterial efflux pump inhibitors and are used in combination with an anti-bacterial agent to treat or prevent bacterial infections. These combinations can be effective against bacterial infections that have developed resistance to anti-bacterial agents through an efflux pump mechanism.
Type:
Application
Filed:
May 6, 2008
Publication date:
December 25, 2008
Applicant:
Mpex Pharmaceuticals, Inc.
Inventors:
TOMASZ GLINKA, Olga Lomovskaya, Keith Bostian, David M. Wallace