Patents Assigned to MRIGlobal
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Patent number: 11400454Abstract: A mobile field-deployable laboratory to more conveniently enable the detecting, sequencing and analyzing of biological agents at the point-of-need. This device enables field operators to go from sample to actionable information in the field without the need for an internet connection or grid-based power. The present mobile laboratory is configured in a footlocker configuration including a plurality of different compartments specifically configured for holding all of the necessary equipment for use in a wide variety of different applications including successfully extracting, amplifying, sequencing and characterizing specific viruses, pathogens and other bacteria directly in the field including an integrated power supply for providing power to the relevant components for up to 72 hours of continuous use without the need for any external power source. The present mobile laboratory includes a deployable workbench area which provides a stable workstation when the footlocker configuration is deployed.Type: GrantFiled: November 9, 2018Date of Patent: August 2, 2022Assignee: MRIGlobalInventors: Jonathan L. Jacobs, Joseph A. Russell, Jacob R. Aspinwall
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Patent number: 10913709Abstract: Disclosed is a salt prepared from the STAT3 inhibitor known as 2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino] benzoic acid and 2-amino-2-(hydroxymethyl)-1,3-propanediol. The salt is soluble in water and stable for extended periods of time. Further provided are pharmaceutical compositions comprising the salt and methods of administering the salt to prevent and treat cancer, such as breast cancer.Type: GrantFiled: April 5, 2018Date of Patent: February 9, 2021Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, GLG Pharma, LLC, MRIGlobalInventors: Robert H. Shoemaker, Michael W. Lovell, Jonathan M. White, Shanker Gupta
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Publication number: 20200109109Abstract: Disclosed is a salt prepared from the STAT3 inhibitor known as 2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino] benzoic acid and 2-amino-2-(hydroxymethyl)-1,3-propanediol. The salt is soluble in water and stable for extended periods of time. Further provided are pharmaceutical compositions comprising the salt and methods of administering the salt to prevent and treat cancer, such as breast cancer.Type: ApplicationFiled: April 5, 2018Publication date: April 9, 2020Applicants: The United States of America,as represented by the Secretary,Department of Health and Human Services, GLG Pharma, LLC, MRIGlobalInventors: Robert H. Shoemaker, Michael W. Lovell, Jonathan M. White, Shanker Gupta
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Patent number: 9051558Abstract: A method of culturing fastidious bacteria where a conditioned cell culture medium is prepared in which eukaryotic cells have been cultured, but where the medium is substantially free of the cultured cells. Fastidious bacteria are cultured in the medium. The conditioned cell culture medium can contain secreted factors from the cells. These factors promote the growth of the fastidious bacteria. The fastidious bacterial culture is maintained for a time period sufficient for the fastidious bacteria to multiply. The fastidious bacteria are analyzed using PCR, DNA sequencing or microbiology characterization.Type: GrantFiled: August 21, 2013Date of Patent: June 9, 2015Assignee: MRIGLOBALInventors: Kelly Brown, Richard Winegar, Jacqueline Bortzner, Nicole Moritz, Stephanie Sorrell
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Publication number: 20140057272Abstract: A method of culturing fastidious bacteria where a conditioned cell culture medium is prepared in which eukaryotic cells have been cultured, but where the medium is substantially free of the cultured cells. Fastidious bacteria are cultured in the medium. The conditioned cell culture medium can contain secreted factors from the cells. These factors promote the growth of the fastidious bacteria. The fastidious bacterial culture is maintained for a time period sufficient for the fastidious bacteria to multiply. The fastidious bacteria are analyzed using PCR, DNA sequencing or microbiology characterization.Type: ApplicationFiled: August 21, 2013Publication date: February 27, 2014Applicant: MRIGlobalInventors: Kelly Brown, Richard Winegar, Jacqueline Bortzner, Nicole Moritz, Stephanie Sorrell
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Patent number: 8522868Abstract: The present invention is generally directed to a method for releasing trapped oil in reservoirs. The method hereof includes identifying a reservoir, obtaining a microbial community sample of the reservoir, maintaining the sample under high temperature and high pressure conditions that mimic natural conditions of the reservoir, growing the sample on at least one substrate, determining a targeted treatment regime for the reservoir based on the positive growth of the sample on the substrate, injecting the reservoir with the targeted substrate to release trapped oil in the reservoir, monitoring the reservoir, and extracting the oil from the reservoir.Type: GrantFiled: June 1, 2012Date of Patent: September 3, 2013Assignee: MRIGlobalInventor: F. Prescott Ward
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Patent number: 8517092Abstract: The method hereof is for releasing trapped oil in reservoirs and includes identifying a reservoir, obtaining a microbial community sample of the reservoir, maintaining the sample under high temperature and high pressure conditions that mimic natural conditions of the reservoir, growing the sample on at least one substrate, determining a targeted treatment regime for the reservoir based on the positive growth of the sample on the substrate, injecting the reservoir with the targeted substrate to release trapped oil in the reservoir, monitoring the reservoir, and extracting the oil from the reservoir.Type: GrantFiled: September 17, 2010Date of Patent: August 27, 2013Assignee: MRIGlobalInventor: F. Prescott Ward
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Patent number: 8230719Abstract: The present invention is directed to a method for multidimensional gas chromatography for separating the analytes of a complex sample. The method comprises the steps of introducing the sample onto a first column whereby the sample is separated into at least two segments, introducing at least one segment into a heartcut device whereby the segments are selectively separated into at least two heartcut fractions, introducing at least one of the fractions onto a second column whereby at least one fraction is further separated into at least two analytes, introducing at least one analyte from the second column to a gas chromatography connector, introducing the analyte from the connector to a third column, and introducing the analyte from the third column into a detector whereby the analyte is analyzed and identified.Type: GrantFiled: April 27, 2010Date of Patent: July 31, 2012Assignee: MRIGlobalInventor: Chad Fisher