Abstract: The invention discloses a pharmaceutical composition comprising phenylephrine or a pharmaceutically acceptable salt thereof and an erodible layer which is for oral administration wherein the composition delivers phenylephrine or a pharmaceutically acceptable salt thereof via absorption in the colon. The pharmaceutical composition comprises a core comprising phenylephrine or a pharmaceutically acceptable salt thereof and an erodible layer which is in a time-dependent, pH-dependent, or colon-specific enzyme-dependent erodible layer that degrades to expose the core to release phenylephrine in the colon. In one preferred embodiment, the erodible layer encases the core. The composition optionally further comprises phenylephrine in the erodible layer or other additional layer(s).

Abstract: The invention provides antioxidant-containing compositions and methods for confirming antioxidant activity of a composition formulated for topical application to skin. The invention also provides methods for testing a composition for the ability to inhibit both ultraviolet radiation-induced lipid peroxidation on skin and ultraviolet radiation-induced reactive oxygen species formation in the stratum corneum as well as compositions and methods for treating and preventing photodamage to skin.

Abstract: A kiosk apparatus that may select for a person a recommended footcare product based on pressure measurements collected from pressures sensors or calculated biomechanical data estimates. Pressure measurements and calculated biomechanical data estimates may be used to determine if a foot is unshod on the pressure sensor and also group a person into a classified subgroup. The pressure measurement and calculated biomechanical data estimates may also be used to select a recommended footcare product.

Abstract: The invention discloses a pharmaceutical composition comprising phenylephrine or a pharmaceutically acceptable salt thereof and an erodible layer which is for oral administration wherein the composition delivers phenylephrine or a pharmaceutically acceptable salt thereof via absorption in the colon. The pharmaceutical composition comprises a core comprising phenylephrine or a pharmaceutically acceptable salt thereof and an erodible layer which is in a time-dependent, pH-dependent, or colon-specific enzyme-dependent erodible layer that degrades to expose the core to release phenylephrine in the colon. In one preferred embodiment, the erodible layer encases the core. The composition optionally further comprises phenylephrine in the erodible layer or other additional layer(s).

Abstract: Fitment and container for powdered products, especially powdered products prone to clumping behavior, comprising a stopper that closes the passageway between the interior chamber and the mouth of the container, a pour spout in the stopper that permits the powdered product to flow through the passageway during a pouring operation, and one or more baffles connected to the stopper and extending into the interior chamber of the container, the baffles being configured to break apart clumps of the powdered product before the clumps can flow through the pour spout. The pour spout further includes a restriction element, associated with the pour spout, configured to break apart clumps that reach the pour spout without being broken apart by the baffles. The invention promotes a consistent and predictable rate of flow in the stream of powdered product flowing out of the container during the pouring operation.

Abstract: A low ether gel composition for application to skin comprising a keratolytic agent, in particular salicylic acid, and comprising a nitrocellulose and one or more volatile ingredients, which forms a film on contact with skin adequate to form a protective barrier for the keratolytic agent for a period of time necessary to provide treatment to the skin; methods of treating using such compositions, and dispensers containing such compositions.

Abstract: Compositions comprising UV blocking agents, a film forming polymer containing acid groups and a neutralizing agent; compositions and methods for increasing the SPF of a composition by neutralizing at least a portion of the acid groups of the film forming agent with the neutralizing agent.

Abstract: An orthotic is disclosed. The orthotic may include a cushioning layer configured to extend from at least the metatarsal region to the proximal heel region, the cushioning layer having a heel region with a protruding heel piece integrally molded as part of the cushioning layer. The orthotic may also include an outer shell layer fixedly coupled to the cushioning layer, the outer shell layer extending longitudinally from at least the medial cuneiform-first metatarsal joint region to the calcaneus bone region of the user, the outer shell layer configured to receive the protruding heel piece.

Abstract: A cushioning device including a layer of styrenic based gel material having top and bottom surfaces, a first layer including: i. layer of maleic anhydride and ii. layer of thermoplastic polyurethane, wherein the first layer has a surface bonded to the top surface of the layer of styrenic based gel material, the second layer has a surface bonded to the bottom of the layer of styrenic based gel material and wherein a pressure sensitive adhesive coating is disposed on at least one of the first and second layers opposite to the layer of styrenic based gel material.