Patents Assigned to MSD International GMBH
  • Publication number: 20210205339
    Abstract: The present invention relates to Compounds of Formula (I) or Formula (II): or a pharmaceutically acceptable salt, solvate or enantiomer thereof, wherein A, B, R1, R2, R3, R4, Q and V are as defined herein. The present invention also relates to pharmaceutical compositions comprising a Compound of Formula (I) or Formula (II) and to their use in therapy.
    Type: Application
    Filed: November 24, 2020
    Publication date: July 8, 2021
    Applicant: MSD International GMBH
    Inventors: Cyril B. Dousson, David Dukhan, Christophe C. Parsy, Stephane L. Bogen
  • Patent number: 11030750
    Abstract: Approaches for the automatic segmentation of magnetic resonance (MR) images. Machine learning models segment images to identify image features in consecutive frames at different levels of resolution. A neural network block is applied to groups of MR images to produce primary feature maps at two or more levels of resolution. The images in a given group of MR images may correspond to a cycle and have a temporal order. A second RNN block is applied to the primary feature maps to produce two or more output tensors at corresponding levels of resolution. A segmentation block is applied to the two or more output tensors to produce a probability map for the MR images. The first neural network block may be a convolutional neural network (CNN) block. The second neural network block may be a convolutional long short-term (LSTM) block.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: June 8, 2021
    Assignees: Merck Sharp & Dohme Corp., MSD International GmbH
    Inventors: Antong Chen, Dongqing Zhang, Ilknur Icke, Belma Dogdas, Sarayu Parimal
  • Patent number: 9573959
    Abstract: This invention relates to methods for preparing a sodium-glucose transporter 2 (SGLT2) inhibitor, a cocrytalline SGLT2 and (S)-5-oxopyrrolidine-2-carboxylic acid (L-PGA) complex, and intermediates useful in the preparation of the said SGLT2 inhibitor.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: February 21, 2017
    Assignee: MSD International GMBH
    Inventors: Steven J. Brenek, Stephane Caron, Jade D. Nelson, Mark E. Webster, Rodney Matthew Weekly