Abstract: A structural gene coding for authentic human serum albumin, --optionally supplemented by an upstream triplet coding for methionine and optionally extended by a synthetic prepro.sup.x -leader-coding sequence--, wherein the codons of the nucleotide sequence have been selected with regard to a non-human host, e.g. yeast, chosen for expression of authentic human serum albumin, is disclosed.Additionally there is disclosed a method of producing said gene.There are also disclosed a recombinant DNA molecule comprising said strucural gene inserted into a vector, and a host transformed with said recombinant DNA molecule.Furthermore there are disclosed a method of producing authentic human serum albumin, an authentic human serum albumin resulting from said method, and a pharmaceutical composition comprising said resulting human serum albumin.
Type:
Grant
Filed:
May 13, 1992
Date of Patent:
March 9, 1999
Assignees:
Skandigen AB, MTA Szegedi Biologiai Kozpontja, Vepex Contractor Ltd.
Abstract: The invention relates to a process for the preparation of oligo- and polydeoxyribonucleotides by synthesizing the complementary strand of a single-stranded DNA piece enzymatically, in the presence of deoxyribonucleoside 5'-triphosphates in a cloning vector.
Type:
Grant
Filed:
November 22, 1985
Date of Patent:
February 2, 1993
Assignees:
Vepex Contractor Ltd., Mta Szegedi Biologiai Kozpontja
Inventors:
Andras Simoncsits, Miklos Kalman, Csaba Kari, Imre Cserpan