Abstract: A 12 to 30 nucleotide-unit long oligonucleotide that comprises at least one 5-substituted uracil or cytosine, where the 5-substituent is a C.sub.3-6 n-alkyl, a vinyl, a butenyl, an ethynyl, or a C.sub.4-12 n-1-alkynyl, with the proviso that the uracil moiety may not be substituted with an n-alkyl or a C.sub.8-12 n-1-alkynyl.
Type:
Grant
Filed:
September 22, 1997
Date of Patent:
June 16, 1998
Assignee:
MTA Zozponti Kemiai Kutato Intezet
Inventors:
Laszlo Otvos, Janos Sagi, Attila Szemzo, Gyula Sagi, Ottone Szabolcs, Eva Ruff, Katalin Ebinger, Ferencne Tudos, Iren Fellegvari