Patents Assigned to MTI Biotech, Inc.

Compositions and methods of use of gamma-ketoaldheyde scavengers for treating, preventing or improving fibrosis of the liver

Patent number: 12636269

Abstract: Methods and compositions for use in treating, attenuating, preventing or improving liver fibrosis in a subject are described. The compounds of the present invention are gamma-ketoaldehyde scavengers.

Type: Grant

Filed: June 23, 2023

Date of Patent: May 26, 2026

Assignee: MTI Biotech, Inc.

Inventors: John Rathmacher, Naji Abumrad, Charles Flynn
Triphenylphosphonium-tethered salicylamine derivatives

Patent number: 12435025

Abstract: Novel salicylamine derivatives are targeted directly to the mitochondria to increase effectiveness and lower required dosages in the treatment of conditions caused by inflammation or oxidative stress.

Type: Grant

Filed: January 27, 2020

Date of Patent: October 7, 2025

Assignee: MTI Biotech, Inc.

Inventors: Kevin Moore, Michael P. Murphy, Naji Abumrad, John Fuller, Jr.
Compositions and methods of use of ?-ketoaldehyde scavengers for treating, preventing or improving nonalcoholic fatty liver disease (NAFLD), NASH, ALD or conditions related to the liver

Patent number: 12383515

Abstract: Methods and compositions for use in treating, preventing or improving diseases related to the liver in an animal, including but not limited to nonalcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD) or nonalcoholic steatohepatitis (NASH), are described. The compounds of the present invention are gamma-ketoaldehyde scavengers.

Type: Grant

Filed: December 8, 2022

Date of Patent: August 12, 2025

Assignee: MTI Biotech, Inc.

Inventors: John Rathmacher, Naji Abumrad, Charles Flynn

Compositions and methods of use of gamma-ketoaldheyde scavengers for treating, preventing or improving fibrosis of the liver

Triphenylphosphonium-tethered salicylamine derivatives

Compositions and methods of use of ?-ketoaldehyde scavengers for treating, preventing or improving nonalcoholic fatty liver disease (NAFLD), NASH, ALD or conditions related to the liver