Patents Assigned to MULTI MAGNETICS INCORPORATED
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Patent number: 11077215Abstract: The invention provides an improved modified magnetosome that contains more iron therein with the combination of the expressed genes. This is achieved by co-expression of (a) one or more bacterial magnetotactic genes to amplify iron uptake, compartmentalization and biomineralization in cells, with (b) one or more mammalian iron handling proteins that together augment(s) and/or regulate the cells iron pool. As a result, mammalian cells or bacterial cells that are transfected or transformed, respectively, can be more effectively tracked using various imaging technologies.Type: GrantFiled: July 8, 2014Date of Patent: August 3, 2021Assignee: Multi-Magnetics IncorporatedInventors: Donna E. Goldhawk, D. James Koropatnick, Rene Figueredo, Frank S. Prato, R. Terry Thompson, Neil Gelman
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Patent number: 9453922Abstract: A hybrid medical imaging system comprises a nuclear medicine imaging subsystem for capturing an image of a target region of a subject, a magnetic resonance imaging (MRI) subsystem for capturing an MRI image of the target region based on at least one MRI parameter and processing structure communicating with the subsystems. The processing structure processes the MRI image to estimate attenuation within the target region and uses the estimated attenuation to correct the image captured by the nuclear medicine imaging subsystem.Type: GrantFiled: September 9, 2009Date of Patent: September 27, 2016Assignee: Multi-Magnetics IncorporatedInventors: Robert Z. Stodilka, Jean Theberge, Benoit Lewden, Frank S. Prato, R. Terry Thompson
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Patent number: 9128032Abstract: A photoacoustic imaging apparatus is provided for medical or other imaging applications and also a method for calibrating this apparatus. The apparatus employs a sparse array of transducer elements and a reconstruction algorithm. Spatial calibration maps of the sparse array are used to optimize the reconstruction algorithm. The apparatus includes a laser producing a pulsed laser beam to illuminate a subject for imaging and generate photoacoustic waves. The transducers are fixedly mounted on a holder so as to form the sparse array. A photoacoustic (PA) waves are received by each transducer. The resultant analog signals from each transducer are amplified, filtered, and converted to digital signals in parallel by a data acquisition system which is operatively connected to a computer. The computer receives the digital signals and processes the digital signals by the algorithm based on iterative forward projection and back-projection in order to provide the image.Type: GrantFiled: June 11, 2010Date of Patent: September 8, 2015Assignee: MULTI-MAGNETICS INCORPORATEDInventors: Jeffrey J. L. Carson, Pinhas Ephrat, Lynn Keenliside, Michael Barret Roumeliotis
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Patent number: 9095309Abstract: An apparatus for quantifying contrast agent behavior of an administrated contrast agent within a region of interest, comprises an imaging device configured to acquire images of a subject and processing structure communicating with the imaging device. The processing structure is configured to process image data of the acquired images to yield a time sequence of images, I(t), at a location (I) outside of the region of interest that detect contrast agent concentration before the contrast agent enters the region of interest and to yield a time sequence of images, J(t), at a location (J) within the region of interest that detect the contrast agent concentration as the contrast agent perfuses the region of interest.Type: GrantFiled: September 15, 2008Date of Patent: August 4, 2015Assignee: Multi Magnetics IncorporatedInventors: Robert Z. Stodilka, Frank S. Prato
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Publication number: 20100297022Abstract: The invention is the production of magnetosome-like structures in cells. The invention provides in vitro and in vivo diagnostic and therapeutic methods using eukaryotic cells expressing magnetosome-like structures that act as contrast agents.Type: ApplicationFiled: June 8, 2007Publication date: November 25, 2010Applicant: MULTI-MAGNETICS INCORPORATEDInventors: Frank S. Prato, Donna E. Goldhawk, Cheryl R. McCreary, Rebecca McGirr, Savita Dhanvantari, Terry R. Thompson, Alex W. Thomas, David Hill
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Publication number: 20100204563Abstract: A hybrid medical imaging system comprises a nuclear medicine imaging subsystem for capturing an image of a target region of a subject, a magnetic resonance imaging (MRI) subsystem for capturing an MRI image of the target region based on at least one MRI parameter and processing structure communicating with the subsystems. The processing structure processes the MRI image to estimate attenuation within the target region and uses the estimated attenuation to correct the image captured by the nuclear medicine imaging subsystem.Type: ApplicationFiled: September 9, 2009Publication date: August 12, 2010Applicant: MULTI MAGNETICS INCORPORATEDInventors: Robert Z. Stodilka, Jean Theberge, Benoit Lewden, Frank S. Prato, R. Terry Thompson
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Publication number: 20090124898Abstract: A method for quantifying contrast agent behavior of an administrated contrast agent within a region of interest, comprises: obtaining a time sequence of measurements, I(t), of contrast agent concentration starting before the contrast agent enters the region of interest and a time sequence of measurements, J(t), of the contrast agent concentration as the contrast agent perfuses the region of interest; deconvolving I(t) from J(t) to obtain an estimate of the tissue impulse response function for the region of interest, R?(t), where R?(t) is constrained to take into account at least one of physiologic and physical considerations and is chosen such that I(t)R?(t) is the maximum likelihood estimate of J(t), where denotes convolution; and determining the behaviour of the contrast agent in the region of interest based on R?(t).Type: ApplicationFiled: September 15, 2008Publication date: May 14, 2009Applicant: Multi Magnetics IncorporatedInventors: Robert Z. Stodilka, Frank S. Prato
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Publication number: 20080187094Abstract: A system and method for performing local tomography is provided. The system comprises an anatomical imaging subsystem for imaging a patient and generating anatomical image data. A computing device generates an anatomical image from the anatomical image data and identifies a region-of-interest within the anatomical image. A molecular imaging subsystem captures molecular image data from only a portion of the patient including the region-of-interest. The computing device generates a molecular tomographic image of the region-of-interest from the molecular image data and the anatomical image.Type: ApplicationFiled: August 27, 2007Publication date: August 7, 2008Applicant: MULTI MAGNETICS INCORPORATEDInventors: Robert Z. Stodilka, Frank S. Prato