Patents Assigned to MULTIPLICOM NV
  • Patent number: 10767228
    Abstract: The invention relates to prenatal detection methods using non-invasive techniques. In particular, it relates to prenatal diagnosis of a fetal chromosomal aneuploidy by detecting fetal and maternal nucleic acids in a maternal biological sample. More particularly, the invention applies multiplex PCR to amplify selected fractions of the respective chromosomes of maternal and fetal chromosomes. Respective amounts of suspected aneuploid chromosomal regions and reference chromosomes are determined from massive sequencing analysis followed by a statistical analysis to detect a particular aneuploidy.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: September 8, 2020
    Assignee: MULTIPLICOM NV
    Inventors: Jurgen Del-Favero, Dirk Goossens, Lien Heyrman
  • Patent number: 9994906
    Abstract: The invention relates to prenatal detection methods using non-invasive techniques. In particular, it relates to prenatal diagnosis of a fetal chromosomal aneuploidy by detecting fetal and maternal nucleic acids in a maternal biological sample. More particularly, the invention applies multiplex PCR to amplify selected fractions of the respective chromosomes of maternal and fetal chromosomes. Respective amounts of suspected aneuploid chromosomal regions and reference chromosomes are determined from massive sequencing analysis followed by a statistical analysis to detect a particular aneuploidy.
    Type: Grant
    Filed: February 13, 2017
    Date of Patent: June 12, 2018
    Assignee: MULTIPLICOM NV
    Inventors: Jurgen Del-Favero, Dirk Goossens, Lien Heyrman
  • Patent number: 9598730
    Abstract: The invention relates to prenatal detection methods using non-invasive techniques. In particular, it relates to prenatal diagnosis of a fetal chromosomal aneuploidy by detecting fetal and maternal nucleic acids in a maternal biological sample. More particularly, the invention applies multiplex PCR to amplify selected fractions of the respective chromosomes of maternal and fetal chromosomes. Respective amounts of suspected aneuploid chromosomal regions and reference chromosomes are determined from massive sequencing analysis followed by a statistical analysis to detect a particular aneuploidy.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: March 21, 2017
    Assignee: MULTIPLICOM NV
    Inventors: Jurgen Del-Favero, Dirk Goossens, Lien Heyrman